Protein Alignment Ank2 and LOC3291724

DIOPT Version :10

• Sequence 1: NP_001189070.1
• Gene: Ank2 / 38863
• FlyBaseID: FBgn0261788
• Length: 13559
• Species: Drosophila melanogaster
• Sequence 2: XP_061513318.1
• Gene: LOC3291724 / 3291724
• VectorBaseID: AGAMI1_008985
• Length: 1857
• Species: Anopheles gambiae
• Alignment Length: 792
• Identity: 206/792 - (26%)
• Similarity: 341/792 - (43%)
• Gaps: 112/792 - (14%)

  Fly    36 DINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHN 100
            |:| ::||. ..||.|...|::.:::.||.:...::...:.|.|.|.:|......|:||.|....
Mosquito  1119 DVN-ADANA-EILHYAVLSGNVELLNLLLDQCHDLNQRDEDGQTPLEVACKLSNVEMVKALTNAG 1181

  Fly   101 ASVNVQSQNGFTPL-YMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQ---QGHDKVVAV 161
            |......::|::.. ::....:.||:|  .|.|  |:.|:.:.....:.:.:|   .|::::|..
Mosquito  1182 ARWYTNGEHGYSQYSWIFLNNDQDAIV--FLKN--NELLSGKVAGACVTLFLQYCDDGNEEIVEF 1242

  Fly   162 LLESDTRGKVRLPALHIAAKK-DDVKAATLLLDNDH--NPDVTSKS---GFTPLHIASHYGNQNI 220
            :|.::|   |...||:.|..: ..:.....|:::|.  :.:|..|.   |.|||.||:..|..::
Mosquito  1243 MLANET---VEYGALYPATVRFRRLNVLRFLIESDRKVSSNVNRKEGSMGLTPLQIAARMGYADV 1304

  Fly   221 ANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQ 285
            |.:|:::||.|.....|..|.||.|.:.|....|.|||..|.::..:...|.:||..|....|.:
Mosquito  1305 AKILLEQGAKVQLRDAHGNSALHYAVECGCVKTVRLLLRHGASVGVRNSLGQSPLEIAIAREHRK 1369

  Fly   286 VVDMLLERGAPISA-----KTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAA 345
            :|.:|...|..:.:     :.:||      |...:.:..|:...|..:|.| |:.|..|.||
Mosquito  1370 LVRLLAHSGQKVDSVMLPERLRNG------AIVEDLLPVAKRFEYSLSPGD-VSSDTFTPLH--- 1424

  Fly   346 HCGHVRVAKLLLDRNADANARALNGF---------------TPLHIACKKNRLKVVELLLRHGAS 395
               |.|            :.||:..|               ||||:||..|....|..||:|||.
Mosquito  1425 ---HAR------------DERAIQQFLQLYEIDVASPRYRTTPLHLACLSNDPLRVRALLKHGAD 1474

  Fly   396 ISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDV-PTVRGE--TPLHLAARANQTDIIRILLR 457
            .:.....|.|||.:|......:||..||:|.:.... ||...|  |.|.:|.|....:|..:||:
Mosquito  1475 PTLANSEGRTPLLLAVGNRSTSIVQTLLEHRSLQQARPTTHDELDTVLAIAIRKQSIEIANLLLQ 1539

  Fly   458 NGAQVD--ARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAV 520
            .||.:|  .|.....:|.|                .|.....|.|..:.....||::|.:.:...
Mosquito  1540 KGASIDTIGRTLTALSPTH----------------RGISTTTTPKHPHQLFFCAARDGYNRILEY 1588

  Fly   521 LIENGAALDAATKK--GFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVAC------- 576
            |:| ||..|...|.  |.|.|........:....:||:..|||:...:.|...|.:|.
Mosquito  1589 LLE-GALFDVNAKDTIGSTALFHALSRAPLDTLDILLRYGADVEHSNQFGHNVLSIAAMNNRLDA 1652

  Fly   577 ---HYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEY----GALANAESKAG 634
               ..||....:.||:   :.....||  :.||:|..:..::|....::.    |...:|::|.|
Mosquito  1653 LQYFVNNFPTLVRLLD---AVEVDTKN--SVLHLAVLRGALEIVQYCVKLHRTGGISLDAQNKEG 1712

  Fly   635 FTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGA---NIDMA 696
            ||.||:|:|.||..|...|:.|.|....|:.||.:.:|......|:|:.:|:.:.|.   ..|:.
Mosquito  1713 FTALHISAQTGHEAIFGYLLSHGANATIPSANGQSILHTAICNRNLNIVQIIHRAGVLPLEQDLF 1777

  Fly   697 TKAGYTPLHVASHFGQANMVRFLLQ-NGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANAN 760
            .....:|||.|....|..:||.:|: .|..::.|.:.|.|.||..|:..:..|.| ||:.:.:..
Mosquito  1778 DHDERSPLHYAVLSRQVEVVREVLKLPGLPLNHADARGNTALHLAAEFQYVDIYN-LLQKRIDNE 1841

  Fly   761 AQTVNGQTPLHI 772
            .:..||:..:.:
Mosquito  1842 VRNGNGKRAIDV 1853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANKYR	10..308	CDD:440430	73/286 (26%)
		ANK repeat	10..41	CDD:293786	2/4 (50%)
		ANK repeat	43..74	CDD:293786	7/30 (23%)
		ANK repeat	76..107	CDD:293786	9/30 (30%)
		ANK repeat	109..134	CDD:293786	6/25 (24%)
		ANK repeat	175..202	CDD:293786	6/29 (21%)
		ANKYR	190..473	CDD:440430	89/312 (29%)
		ANK repeat	204..235	CDD:293786	12/33 (36%)
		ANK repeat	237..268	CDD:293786	11/30 (37%)
		ANK repeat	270..300	CDD:293786	8/34 (24%)
		ANK repeat	303..367	CDD:293786	14/63 (22%)
		ANK repeat	369..400	CDD:293786	14/45 (31%)
		ANKYR	383..671	CDD:440430	84/308 (27%)
		ANK repeat	402..433	CDD:293786	10/31 (32%)
		ANK repeat	435..466	CDD:293786	11/34 (32%)
		ANK repeat	468..497	CDD:293786	3/28 (11%)
		ANK repeat	501..530	CDD:293786	7/28 (25%)
		ANK repeat	535..565	CDD:293786	8/29 (28%)
		ANK repeat	567..598	CDD:293786	7/40 (18%)
		PHA03100	599..>773	CDD:476869	52/182 (29%)
		ANK repeat	600..630	CDD:293786	6/33 (18%)
		ANK repeat	633..662	CDD:293786	13/28 (46%)
		ANK repeat	666..697	CDD:293786	8/33 (24%)
		ANK repeat	699..730	CDD:293786	9/31 (29%)
		ANK repeat	732..762	CDD:293786	9/29 (31%)
		ZU5	930..1027	CDD:459941
		UPA_2	1253..1384	CDD:375346
		Death_ank	1417..1497	CDD:260029
		PTZ00121	<1443..2235	CDD:173412
		PTZ00449	<3292..3611	CDD:185628
		PTZ00449	<4400..4857	CDD:185628
		PTZ00449	<4908..5267	CDD:185628
		PTZ00108	<5179..5374	CDD:240271
		PTZ00108	<6034..6230	CDD:240271
		PTZ00449	<6620..6979	CDD:185628
		PTZ00108	<7119..7314	CDD:240271
		PTZ00108	<7347..7544	CDD:240271
		PTZ00108	<7651..7848	CDD:240271
		PTZ00449	<7804..8119	CDD:185628
		PTZ00108	<8183..8381	CDD:240271
		PTZ00449	<8430..8745	CDD:185628
		PTZ00449	<8784..9125	CDD:185628
		PTZ00449	<9028..9353	CDD:185628
		PHA03307	9225..>9575	CDD:223039
		PHA03307	9903..>10259	CDD:223039
		PTZ00108	<10177..10451	CDD:240271
LOC3291724	XP_061513318.1	None