DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and Ankrd44

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	XP_006496133.1	Gene:	Ankrd44 / 329154	MGIID:	3045243	Length:	1074	Species:	Mus musculus

Alignment Length:	934	Identity:	276/934 - (29%)
Similarity:	405/934 - (43%)	Gaps:	155/934 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKG 77
            |...||..:.:.|.|...:|::.|:|..:.|....||:|:.:..:.....::...:.|:.:.:.|
Mouse    76 TPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 140

  Fly    78 NTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATED 142
            .||||.|:|.|..|:|.|||...|::|...:.....|:.||...|..||.||:::||..:...:.
Mouse   141 RTALHHAALNGHMEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 205

  Fly   143 GFTPLAVAMQQGHDKVVAVLL----ESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSK 203
            |:|||..|...|...||..||    |.|........|||||...........|:|...|.:..:.
Mouse   206 GYTPLHAAASNGQISVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNN 270

  Fly   204 SGFTPLHI--ASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEA 266
            |||||||.  ||.:|...: .||:..|||||..:|...||||:.|..|:......|::.||.|:.
Mouse   271 SGFTPLHFAAASTHGALCL-ELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDC 334

  Fly   267 KTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYH----- 326
            ..:||.||||.|||.|||.:::.|:..||..:....:.:.|||:||...|.|..|.||..
Mouse   335 VDKDGNTPLHVAARHGHELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGQKYS 399

  Fly   327 -----------RAPVDEVTVDYL--TALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIAC 378
                       .|..:..|.|..  |.||.||..|:|...|||....||.:.:...|.||||.|.
Mouse   400 IVSLFSNEHVLSAGFEIDTPDTFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAA 464

  Fly   379 KKNRLKVVELLLRHGASISATTESGLTPLHVAA---------FMG-------------------- 414
            .......::.|:..||:::.|.:.|.|.||.||         .:|
Mouse   465 ANCHFHCIKALVTTGANVNETDDWGRTALHYAAASDMDRNKMILGNAHDNSEELERAREVKEKDA 529

  Fly   415 --CMNIVIYLLQHDASPDVPTVRG-----------------------------------ETPLHL 442
              |:.   :|||:||:|.:....|                                   ::||||
Mouse   530 ALCLE---FLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNTGFEESDGGALKSPLHL 591

  Fly   443 AARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQV---DATTKDMYT 504
            ||.......:.:||::...:|.|..:.:|.|::|:..|:.:.|..|:..||.:   |..||  .|
Mouse   592 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALYLAAFKGHTECVEALVNQGASIFVKDNVTK--RT 654

  Fly   505 ALHIAAKEGQDEVAAVLIE---NGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGK 566
            .||.:...|......:|:|   |...:|....||.|||.|...||||....|||:|||:|||...
Mouse   655 PLHASVINGHTLCLRLLLETADNPEVVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDAVDI 719

  Fly   567 NGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAE- 630
            .|.|.||......:::...:|||:.||.......|.||||.||.:..   ||.|.|...:|.:|
Mouse   720 VGCTALHRGIMTGHEECVQMLLEQEASILCKDSRGRTPLHYAAARGH---ATWLNELLQIALSEE 781

  Fly   631 -----SKAGFTPLHLSSQEGHAEISNLLIE---------------HKAAVN-HPA---------- 664
                 ...|:||||.:...|:.....:|:|               |.|.:| |.:
Mouse   782 DCCLKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINGHESCASLLLGAID 846

  Fly   665 --------KNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQ 721
                    ..|.|.:|..|..|:....::|.::.|.::....:|.|.|.:|:..|||..|..|:
Mouse   847 PSIVSCRDDKGRTTLHAAAFGDHAECLQLLLRHDAQVNAVDNSGKTALMMAAENGQAGAVDILV- 910

  Fly   722 NGANVDAATSIG--YTPLHQTAQQGH--CHIVNL-LLEHKANANAQTVNGQTPLHIARKLGYISV 781
            |.|..|......  .||||....:||  |.::.| .::.::..||:....|||||||.:.|...|
Mouse   911 NSAQADLTVKDKDLNTPLHLAISKGHEKCALLILDKIQDESLINAKNSALQTPLHIAARNGLKVV 975

  Fly   782 LDSL----KTITKEDETAAAPSQA 801
            ::.|    ..:...||....|:.|
Mouse   976 VEELLAKGACVLAVDENGHTPALA 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	8/27 (30%)
		Ank_4	11..64	CDD:290365	12/50 (24%)
		ANK	38..163	CDD:238125	39/124 (31%)
		ANK repeat	43..74	CDD:293786	5/30 (17%)
		Ank_2	48..135	CDD:289560	28/86 (33%)
		ANK repeat	76..107	CDD:293786	15/30 (50%)
		ANK repeat	109..134	CDD:293786	8/24 (33%)
		Ank_4	110..163	CDD:290365	18/52 (35%)
		Ank_4	172..225	CDD:290365	19/54 (35%)
		ANK repeat	175..202	CDD:293786	8/26 (31%)
		ANK	199..324	CDD:238125	51/126 (40%)
		ANK repeat	204..235	CDD:293786	17/32 (53%)
		Ank_2	209..300	CDD:289560	38/92 (41%)
		ANK repeat	237..268	CDD:293786	10/30 (33%)
		ANK	266..390	CDD:238125	46/141 (33%)
		ANK repeat	270..300	CDD:293786	15/29 (52%)
		ANK repeat	303..367	CDD:293786	25/81 (31%)
		Ank_2	308..399	CDD:289560	33/108 (31%)
		ANK	364..489	CDD:238125	40/190 (21%)
		ANK repeat	369..400	CDD:293786	9/30 (30%)
		ANK repeat	402..433	CDD:293786	14/61 (23%)
		Ank_4	403..456	CDD:290365	21/118 (18%)
		ANK repeat	435..466	CDD:293786	10/65 (15%)
		Ank_2	440..530	CDD:289560	27/95 (28%)
		ANK	463..588	CDD:238125	44/130 (34%)
		ANK repeat	468..497	CDD:293786	8/31 (26%)
		ANK repeat	501..530	CDD:293786	7/31 (23%)
		Ank_2	506..597	CDD:289560	35/93 (38%)
		ANK	529..654	CDD:238125	48/130 (37%)
		ANK repeat	535..565	CDD:293786	18/29 (62%)
		ANK repeat	567..598	CDD:293786	9/30 (30%)
		Ank_2	572..661	CDD:289560	30/109 (28%)
		ANK repeat	600..630	CDD:293786	12/29 (41%)
		ANK repeat	633..662	CDD:293786	11/44 (25%)
		ANK	661..785	CDD:238125	40/147 (27%)
		ANK repeat	666..697	CDD:293786	7/30 (23%)
		Ank_2	672..762	CDD:289560	26/94 (28%)
		ANK repeat	699..730	CDD:293786	12/30 (40%)
		ANK repeat	732..762	CDD:293786	9/34 (26%)
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
Ankrd44	XP_006496133.1	ANK repeat	11..38	CDD:293786
		Ank_2	12..104	CDD:372319	8/27 (30%)
		ANK repeat	40..71	CDD:293786
		ANK repeat	76..104	CDD:293786	8/27 (30%)
		PHA03095	86..>359	CDD:222980	95/273 (35%)
		ANK repeat	106..137	CDD:293786	5/30 (17%)
		ANK repeat	140..170	CDD:293786	15/29 (52%)
		ANK repeat	172..203	CDD:293786	10/30 (33%)
		ANK repeat	205..236	CDD:293786	12/30 (40%)
		ANK repeat	238..266	CDD:293786	8/27 (30%)
		ANK repeat	271..302	CDD:293786	17/31 (55%)
		ANK repeat	305..336	CDD:293786	10/30 (33%)
		ANK repeat	338..369	CDD:293786	15/30 (50%)
		PHA03095	355..>682	CDD:222980	81/331 (24%)
		ANK repeat	375..420	CDD:293786	12/44 (27%)
		ANK repeat	422..453	CDD:293786	12/30 (40%)
		ANK repeat	455..486	CDD:293786	9/30 (30%)
		ANK repeat	488..547	CDD:293786	14/61 (23%)
		ANK repeat	549..580	CDD:293786	1/30 (3%)
		ANK repeat	587..615	CDD:293786	9/27 (33%)
		ANK repeat	617..685	CDD:293786	19/69 (28%)
		PHA03095	669..>984	CDD:222980	96/318 (30%)
		ANK repeat	687..718	CDD:293786	19/30 (63%)
		ANK repeat	720..751	CDD:293786	9/30 (30%)
		ANK repeat	789..813	CDD:293786	8/23 (35%)
		ANK repeat	821..854	CDD:293786	4/32 (13%)
		ANK repeat	857..887	CDD:293786	7/29 (24%)
		ANK repeat	889..921	CDD:293786	12/32 (38%)
		ANK repeat	923..954	CDD:293786	8/30 (27%)
		ANK repeat	959..990	CDD:293786	10/30 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710