DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and Ankef1

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:NP_783598.1 Gene:Ankef1 / 319196 MGIID:2441685 Length:775 Species:Mus musculus


Alignment Length:622 Identity:137/622 - (22%)
Similarity:234/622 - (37%) Gaps:131/622 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 GNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATE 141
            |.:|||:||::...::|..||:..|..:||...|.||...||:..|:..:.:|....|:.::...
Mouse    48 GLSALHLASISNDTDMVSFLLKLGAHPDVQDHMGCTPTMRAAELGHELSMEILAKAKADMTIVDN 112

  Fly   142 DG--------------FTPLAVAMQQGHDKVVAVLLESDTRGKVRLPA-LHIAAKKDDVKAATL- 190
            :|              :....:|::.|.| |..:..|    ||   |. |....:..|||...| 
Mouse   113 EGKGVLFYCILPTKRHYRCSLIALEHGAD-VNNITYE----GK---PVFLRACEEAHDVKDMCLT 169

  Fly   191 LLDNDHNPD-VTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMV 254
            .|:...||: :.:.:|.|.|..:|..|...|...::::|.:||..........|.|||.|..:::
Mouse   170 FLEKGANPNAINTSTGRTALMESSREGVLEIVRGILERGGEVNAYDNDRHHAAHFAAKGGFFDIL 234

  Fly   255 SLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDA 319
            .||....|::.....||.||||.||..|.......:.:||..:..|......|..:|..|....|
Mouse   235 KLLFAYNGDMGLIGMDGNTPLHFAAMGGFADCCKYIAQRGCDLKWKNLEHKTPRVVAKDGGFKAA 299

  Fly   320 AR------------------------ILLYHRAPVDEVTV------------------DYLTAL- 341
            ::                        .|..|...::..|.                  |::.|| 
Mouse   300 SKEIRRAERTAAKLAKTGAKNPNPLWALRLHDWSIEHETSLRNAFKFVDRGDGVVSKDDFVVALE 364

  Fly   342 -----------------HVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELL 389
                             |..:..|.|.:.:........:.:..|..|.|.    ||.|       
Mouse   365 ERQEYATSEQLLSVAQMHEKSRGGGVNINEFFKGTKYLSKSYVLGSFGPK----KKKR------- 418

  Fly   390 LRHGASISATTESGLTPLHVA-----AFM-----GCMNIVIYLLQH---------DASPDVPTVR 435
               |..........:.||.:.     ||.     |....:|...|:         |..|:.| ::
Mouse   419 ---GLGKKPRKGKFVLPLPICTIPENAFPRRPDGGPPYYMIETYQNVSDSHRFNRDHPPEHP-IQ 479

  Fly   436 GETPLHL------------AARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLL 488
            .::..::            ..:|.....::..:..|..||.:....:|||.||...||:|:|..|
Mouse   480 DDSEWYIDDPSRVFANISFITKAGDLASLKKAIETGIPVDMKDNTYKTPLMIACASGNIDVVKFL 544

  Fly   489 LQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQL 553
            ::.||.|:||...::|.||.|...||.::..:|::.||::||.:....|||....:...:...:.
Mouse   545 IEKGANVNATDNFLWTPLHFACHAGQQDIVELLVKAGASIDATSINNSTPLSRAIESCRLDTVKY 609

  Fly   554 LLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEK 590
            ||...|....:.:.|...:.:|..|.:.::..::.||
Mouse   610 LLDMGAKFQIENRKGHAAMDIAKAYADYRIIDMIKEK 646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786
Ank_4 11..64 CDD:290365
ANK 38..163 CDD:238125 25/99 (25%)
ANK repeat 43..74 CDD:293786
Ank_2 48..135 CDD:289560 19/57 (33%)
ANK repeat 76..107 CDD:293786 11/29 (38%)
ANK repeat 109..134 CDD:293786 7/24 (29%)
Ank_4 110..163 CDD:290365 13/66 (20%)
Ank_4 172..225 CDD:290365 15/55 (27%)
ANK repeat 175..202 CDD:293786 8/29 (28%)
ANK 199..324 CDD:238125 33/149 (22%)
ANK repeat 204..235 CDD:293786 9/30 (30%)
Ank_2 209..300 CDD:289560 26/90 (29%)
ANK repeat 237..268 CDD:293786 8/30 (27%)
ANK 266..390 CDD:238125 31/183 (17%)
ANK repeat 270..300 CDD:293786 11/29 (38%)
ANK repeat 303..367 CDD:293786 13/123 (11%)
Ank_2 308..399 CDD:289560 19/150 (13%)
ANK 364..489 CDD:238125 30/155 (19%)
ANK repeat 369..400 CDD:293786 6/30 (20%)
ANK repeat 402..433 CDD:293786 9/49 (18%)
Ank_4 403..456 CDD:290365 11/83 (13%)
ANK repeat 435..466 CDD:293786 4/42 (10%)
Ank_2 440..530 CDD:289560 28/101 (28%)
ANK 463..588 CDD:238125 36/124 (29%)
ANK repeat 468..497 CDD:293786 13/28 (46%)
ANK repeat 501..530 CDD:293786 9/28 (32%)
Ank_2 506..597 CDD:289560 21/85 (25%)
ANK 529..654 CDD:238125 13/62 (21%)
ANK repeat 535..565 CDD:293786 6/29 (21%)
ANK repeat 567..598 CDD:293786 5/24 (21%)
Ank_2 572..661 CDD:289560 4/19 (21%)
ANK repeat 600..630 CDD:293786
ANK repeat 633..662 CDD:293786
ANK 661..785 CDD:238125
ANK repeat 666..697 CDD:293786
Ank_2 672..762 CDD:289560
ANK repeat 699..730 CDD:293786
ANK repeat 732..762 CDD:293786
ZU5 927..1030 CDD:128514
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
Ankef1NP_783598.1 ANK 47..161 CDD:238125 30/120 (25%)
ANK repeat 47..78 CDD:293786 11/29 (38%)
ANK 1 47..76 10/27 (37%)
Ank_2 52..143 CDD:289560 22/91 (24%)
ANK repeat 80..111 CDD:293786 8/30 (27%)
ANK repeat 113..143 CDD:293786 4/30 (13%)
ANK 143..270 CDD:238125 38/133 (29%)
ANK 2 184..213 8/28 (29%)
ANK repeat 185..215 CDD:293786 9/29 (31%)
Ank_2 189..277 CDD:289560 26/87 (30%)
ANK repeat 217..248 CDD:293786 8/30 (27%)
ANK 3 217..246 8/28 (29%)
ANK repeat 250..281 CDD:293786 11/30 (37%)
ANK 4 250..279 11/28 (39%)
EFh 340..395 CDD:298682 6/54 (11%)
Ank_2 <501..555 CDD:289560 18/53 (34%)
ANK 519..643 CDD:238125 36/123 (29%)
ANK 5 524..553 13/28 (46%)
ANK repeat 527..555 CDD:293786 14/27 (52%)
Ank_2 529..621 CDD:289560 30/91 (33%)
ANK repeat 557..588 CDD:293786 11/30 (37%)
ANK 6 557..586 9/28 (32%)
ANK repeat 590..621 CDD:293786 6/30 (20%)
ANK 7 590..619 6/28 (21%)
ANK 8 623..652 5/24 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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