DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ank2 and Ank1

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:XP_038950490.1 Gene:Ank1 / 306570 RGDID:1309620 Length:1946 Species:Rattus norvegicus


Alignment Length:2015 Identity:857/2015 - (42%)
Similarity:1209/2015 - (60%) Gaps:221/2015 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 QGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDS 72
            :.|..||||||||:|||::.|:||:|.:||||.|.||||.||||||:||:.:|.|||.:..|:::
  Rat    56 KADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 120

  Fly    73 ATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQS 137
            .|||||||||||:||||:|||:.|:.:.|:||.|||.|||||||||||||..||:.||.|||||:
  Rat   121 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 185

  Fly   138 LATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTS 202
            :||||||||||||:||||:.|||.|:...|:||||||||||||:.||.:.|.:||.||.||||.|
  Rat   186 VATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 250

  Fly   203 KSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAK 267
            |:||||||||:||.|.|:|.||:.:||.||::.::.|:|||:|::.|...||.|||::|..||.:
  Rat   251 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETR 315

  Fly   268 TRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDE 332
            |:|.|||||||||:||.::.::||:.||||.|||||||:|:||||||:|:|..|:||.:.|.:|:
  Rat   316 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDD 380

  Fly   333 VTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASIS 397
            :|:|:||.|||||||||.||||:|||:.|..|:||||||||||||||||.::|:||||:.||||.
  Rat   381 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASID 445

  Fly   398 ATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQV 462
            |.|||||||||||:|||.:.||..|||..|||:|..|:.|||||:||||..|::.:.||:|.|:.
  Rat   446 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKA 510

  Fly   463 DARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAA 527
            :|:|::.|||||.|:|:|:..:|.|||::.|..:..|...:|.||.||:||..:.|..|:|..|:
  Rat   511 NAKAKDDQTPLHCAARIGHTSMVKLLLENDASPNLATTAGHTPLHTAAREGHVDTALALLEKEAS 575

  Fly   528 LDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGA 592
            ....|||||||||:.||||.:::|:|||:.:|..:|.||||:||||||.|:||..:..|||.:|.
  Rat   576 QACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVQLLLPRGG 640

  Fly   593 SPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHK 657
            |||:.|.||:|||||||::||:::|.:||:||..|||||..|.|||||::||||.|:..||:..:
  Rat   641 SPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQ 705

  Fly   658 AAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQN 722
            |..|...|:||||:||.|||.:|.||::|.|:|..:|..|:.||||||||||:|...:|:||||:
  Rat   706 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQH 770

  Fly   723 GANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSLKT 787
            .|:|:|.|.:||:||||.|||||..||.|||::.|:.|..:.||.|||.||::||||||.|.||.
  Rat   771 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVTDVLKV 835

  Fly   788 ITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDNMLSDQPYRYLTVDEMKSLGDDSL 852
            :|  |||:..  ...:|:|:..||.:.| .:..||:||        ..:..||.||:..      
  Rat   836 VT--DETSVV--LVSDKHRMSYPETVDE-ILDVSEDEG--------TAHISLTGDELVG------ 881

  Fly   853 PIDVTRDERMDSNRMTQSAEYASGVPPTIGEEVISPHKTQVYGSSPKATVDGVYIAN------GS 911
                ::.||.||..:.:..|....| |.:.:.|.||...::    |..|.:.|.|.:      ..
  Rat   882 ----SKAERRDSRDVGEEKELLDFV-PKLDQVVESPAIPRI----PCVTPETVVIRSEDQEQASK 937

  Fly   912 GHDE---------------------PPHVGRKLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPS 955
            .:||                     |.|.|       |||||:||||||:|||.||:|:|::||.
  Rat   938 EYDEDSLIPSSPATETSDNISPVASPVHTG-------FLVSFMVDARGGSMRGSRHNGLRVVIPP 995

  Fly   956 RSTCQPTRVTCRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKERE 1020
            |:...|||:|||.||||:...||.|.|.|.||||::.|||...:|:.||::|:|||||....:||
  Rat   996 RTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRE 1060

  Fly  1021 IIILRSDNGETWREHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSR 1085
            :::|||:||..|:||.....|..:..:|...  .||:..|||.....|||.:|.|||.||.::||
  Rat  1061 LVVLRSENGSVWKEHKSRYGESYLDQILNGM--DEELGSLEELEKKRVCRIITTDFPLYFVIMSR 1123

  Fly  1086 IRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQAQPVDPDLTAKLLGRGVAVSPIVT 1150
            :.|:...||||||.:.|.:||.|||.||:.|:|||:|:.||||||..:|..||||.....|||||
  Rat  1124 LCQDYDTIGPEGGSLRSKLVPLVQATFPENAVTKKVKLALQAQPVPDELVTKLLGNQATFSPIVT 1188

  Fly  1151 VEPRRRKFHKAITLSMPAPKAHSQGMINQYSGNTPTLRLLCSITGGPSRAQWEDVTGSTPLTFVN 1215
            |||||||||:.|.|.:|.|.:.:....:...|:|.:||||||:.||..:|||||:||:|.|.:.|
  Rat  1189 VEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLVYAN 1253

  Fly  1216 DCVSFTTTVSARFWLMDCRNISDATKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKLRVFCMTD 1280
            :|.:|||.|||||||.||...::|...||.||||:..||::||||:|||..:|.|.:||.:||||
  Rat  1254 ECANFTTNVSARFWLSDCPRTAEAVHFATLLYKELTAVPYMAKFVIFAKMNDPREGRLRCYCMTD 1318

  Fly  1281 DREDKTLEKHELYTEVAKSRDVEVLEGKPQYIEMAGNLVPVTKSGDQLQVQFKAFRENRLPFTVR 1345
            |:.|||||:||.:.|||:|||:|||||.|.:.|::||||||.|:..|....|::||||||...|:
  Rat  1319 DKVDKTLEQHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAIPVK 1383

  Fly  1346 VKDQHADIVGRTLFMKEPKVAKGEPPQQPICILNIVLPEAVIPDSTTAFSDRVTSAYRTSMFSLS 1410
            |:|...:..|...|:::|  .|.|..|..:|.||:.:|...  ..:.|...|.|....|..:|:.
  Rat  1384 VRDSSREPGGFLSFLRKP--MKYEDAQHILCHLNVTMPPCT--KGSGAEDRRRTLTPLTLRYSIL 1444

  Fly  1411 KHQNDHYIGD-----IRIVDLSNLLGKDWIQLAPEIGINGEEIDEIINQNTDSIARQAQSMIRLY 1470
            ......:..|     :::..:...||..|.:||.|:..:.|:|:.|..:|.:|:..|:.:::.|:
  Rat  1445 SESRLGFTSDTDRVEMKMAVIREHLGLSWAELARELQFSVEDINRIRVENPNSLLDQSTALLTLW 1509

  Fly  1471 KDK--PNYDILSLETALKNIGRDDIMKKCK-SGRLSHSREFDEADLMKNSESVEELVRRESKRIQ 1532
            .|:  .|..:.:|.|||:||.|.:|:...: |||.|.:.:.|               ||...|  
  Rat  1510 VDREGENAKMENLYTALRNIDRSEIVNMLEGSGRQSRNLKPD---------------RRHGDR-- 1557

  Fly  1533 QINEREEVKYSAEEKEVEESESDEEAAKRTVAERREKIVKRLSIERSIPASTQKKEITREITEIK 1597
                    :||....:|....|           .:::::...|:..::|:.....:...|:..|.
  Rat  1558 --------EYSLSPSQVNGYSS-----------LQDELLSPASLHYALPSPLCADQYWNEVAVID 1603

  Fly  1598 RKSLIEDKKAHHESEILMQLPADNVIIKTTTVPDQVIKMKMGKMDSTEVSKSEFDKELTHKFKTS 1662
            ...|     |..|.:.:::: :|..:..:...|..|    ..:..|.|.||:| |.:...::|..
  Rat  1604 AIPL-----AATEHDTMLEM-SDMQVWSSGLTPSLV----TAEDSSLECSKAE-DSDAIPEWKLE 1657

  Fly  1663 GRSSEEEDQPSYPDQTDKIVQDISAAEKKEKDGVTFSRVTTITRQEARDITEDFL--EIEKRSQL 1725
            |..||:...|           ::.:.:..|.|.|.         .:|.:...|.|  |..:||: 
  Rat  1658 GAHSEDTQGP-----------ELGSQDLVEDDTVD---------SDATNGLADLLGQEEGQRSE- 1701

  Fly  1726 PATSTTATVHEKFVEEIKEKTSPLASVPQETVKEV------QQVISEVTEIASKKVENIISSFES 1784
                              :|:..::...|:|..||      |:|.:.:|:  |..|..::.. ..
  Rat  1702 ------------------KKSQEVSGTEQDTETEVSLVSGQQRVHARITD--SPSVRQVLDR-SQ 1745

  Fly  1785 SKSVD----ATTVLPTQPSVESTKVSETIKNLEDAKAVSAEQVKTVHVVESSSIEETIAEFEAKK 1845
            :::||    .:.....|.:.:|:...|..:..:..:    .::.|:...|..    |:.|:|...
  Rat  1746 ARTVDWYKQGSAASYPQEAAQSSWQEEVTQGPQSFQ----RRITTIQGPEPG----TLQEYEQVV 1802

  Fly  1846 VKYDFH--GGEPKTQIPKFTRKPS-------------DDSMKPTAAPRATVESETESVLETKAEK 1895
            |....|  .|.|::..||..:.||             .|.::.....:.|.|..|:.......:|
  Rat  1803 VSTREHVQRGPPESDSPKAGKDPSLWASESAFSQEVQGDELQNIPGEQVTEEQFTDEQGNIVTKK 1867

  Fly  1896 PISKIPVKTIPTEAQKVSEVDARKITQDFLQGEKLAAE-PKPSP--------AASKIPKVEPRKS 1951
            .|.|:           |.:||:.... |..|.|::..| |...|        :..|:.|||.|.|
  Rat  1868 IIRKV-----------VRQVDSSGAI-DTQQHEEVIVEGPLADPGDLEADIESFMKLTKVELRGS 1920

  Fly  1952  1951
              Rat  1921  1920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786 20/30 (67%)
Ank_4 11..64 CDD:290365 34/52 (65%)
ANK 38..163 CDD:238125 86/124 (69%)
ANK repeat 43..74 CDD:293786 17/30 (57%)
Ank_2 48..135 CDD:289560 57/86 (66%)
ANK repeat 76..107 CDD:293786 20/30 (67%)
ANK repeat 109..134 CDD:293786 18/24 (75%)
Ank_4 110..163 CDD:290365 41/52 (79%)
Ank_4 172..225 CDD:290365 36/52 (69%)
ANK repeat 175..202 CDD:293786 17/26 (65%)
ANK 199..324 CDD:238125 73/124 (59%)
ANK repeat 204..235 CDD:293786 19/30 (63%)
Ank_2 209..300 CDD:289560 48/90 (53%)
ANK repeat 237..268 CDD:293786 14/30 (47%)
ANK 266..390 CDD:238125 81/123 (66%)
ANK repeat 270..300 CDD:293786 18/29 (62%)
ANK repeat 303..367 CDD:293786 39/63 (62%)
Ank_2 308..399 CDD:289560 60/90 (67%)
ANK 364..489 CDD:238125 77/124 (62%)
ANK repeat 369..400 CDD:293786 23/30 (77%)
ANK repeat 402..433 CDD:293786 21/30 (70%)
Ank_4 403..456 CDD:290365 31/52 (60%)
ANK repeat 435..466 CDD:293786 15/30 (50%)
Ank_2 440..530 CDD:289560 38/89 (43%)
ANK 463..588 CDD:238125 60/124 (48%)
ANK repeat 468..497 CDD:293786 13/28 (46%)
ANK repeat 501..530 CDD:293786 11/28 (39%)
Ank_2 506..597 CDD:289560 49/90 (54%)
ANK 529..654 CDD:238125 73/124 (59%)
ANK repeat 535..565 CDD:293786 16/29 (55%)
ANK repeat 567..598 CDD:293786 18/30 (60%)
Ank_2 572..661 CDD:289560 50/88 (57%)
ANK repeat 600..630 CDD:293786 18/29 (62%)
ANK repeat 633..662 CDD:293786 14/28 (50%)
ANK 661..785 CDD:238125 71/123 (58%)
ANK repeat 666..697 CDD:293786 16/30 (53%)
Ank_2 672..762 CDD:289560 51/89 (57%)
ANK repeat 699..730 CDD:293786 19/30 (63%)
ANK repeat 732..762 CDD:293786 18/29 (62%)
ZU5 927..1030 CDD:128514 58/102 (57%)
Death_ank 1417..1497 CDD:260029 24/86 (28%)
ER-remodelling 11936..>12013 CDD:258892
Ank1XP_038950490.1 ANK repeat 61..89 CDD:293786 19/27 (70%)
Ank_2 63..154 CDD:403870 57/90 (63%)
ANK repeat 91..122 CDD:293786 17/30 (57%)
ANK repeat 125..155 CDD:293786 19/29 (66%)
PHA02876 <137..>482 CDD:165207 223/344 (65%)
ANK repeat 157..188 CDD:293786 22/30 (73%)
ANK repeat 190..214 CDD:293786 17/23 (74%)
ANK repeat 223..250 CDD:293786 17/26 (65%)
ANK repeat 253..283 CDD:293786 19/29 (66%)
ANK repeat 285..316 CDD:293786 14/30 (47%)
ANK repeat 318..349 CDD:293786 19/30 (63%)
ANK repeat 351..382 CDD:293786 17/30 (57%)
ANK repeat 387..415 CDD:293786 19/27 (70%)
ANK repeat 417..448 CDD:293786 23/30 (77%)
PHA02875 429..>639 CDD:165206 111/209 (53%)
ANK repeat 450..481 CDD:293786 21/30 (70%)
ANK repeat 483..514 CDD:293786 15/30 (50%)
ANK repeat 516..545 CDD:293786 13/28 (46%)
ANK repeat 550..580 CDD:293786 11/29 (38%)
ANK repeat 582..613 CDD:293786 17/30 (57%)
Ank_2 593..>806 CDD:423045 119/212 (56%)
ANK repeat 615..643 CDD:293786 16/27 (59%)
ANK repeat 648..679 CDD:293786 19/30 (63%)
ANK repeat 681..712 CDD:293786 15/30 (50%)
ANK repeat 714..745 CDD:293786 16/30 (53%)
ANK repeat 747..778 CDD:293786 19/30 (63%)
ANK repeat 780..808 CDD:293786 17/27 (63%)
Ank_4 781..833 CDD:372654 32/51 (63%)
ZU5 966..1070 CDD:128514 59/110 (54%)
UPA_2 1291..1420 CDD:375346 65/130 (50%)
Death_ank1 1456..1539 CDD:260067 23/82 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351943
Domainoid 1 1.000 157 1.000 Domainoid score I4062
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1011028at2759
OrthoFinder 1 1.000 - - FOG0000917
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100012
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.750

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