DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and Tnks

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_001099554.2	Gene:	Tnks / 290794	RGDID:	1308784	Length:	1317	Species:	Rattus norvegicus

Alignment Length:	1164	Identity:	310/1164 - (26%)
Similarity:	491/1164 - (42%)	Gaps:	213/1164 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LRAARAGNLERVLEHLKNNIDINTSNANGL-----NALHLASKDGHIHVVSELLRRGAIVDSATK 75
            |.|.|.|::.||    |..:|....||..:     :.||.|:..|...||..||:.||.|.:...
  Rat   177 LEACRNGDVSRV----KRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 237

  Fly    76 KGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLAT 140
            .|...||.|...|..|||.|||...|..|.:....:|||:.||.:....|..:||.:||:.::..
  Rat   238 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRN 302

  Fly   141 EDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSG 205
            .||.:.|.:|     |.....:|..:.:....|.|   |...::.|...||...:.|...:....
  Rat   303 TDGKSALDLA-----DPSAKAVLTGEYKKDELLEA---ARSGNEEKLMALLTPLNVNCHASDGRK 359

  Fly   206 FTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRD 270
            .||||:|:.|....|..||:|.||||:...|..:.|||.|..:|...:..|||:.|..:.|....
  Rat   360 STPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLW 424

  Fly   271 GLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGE-------------------H 316
            ..||||.||.....:|..:||..||..:....:|.:.:.||...|                   .
  Rat   425 QFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAARE 489

  Fly   317 VDAARI-------LLYHRAPVDEVTVDYLTALHVAA---HCGHVRVAKLLLDRNADANARALNGF 371
            .|.|::       ::..:.|     ..:.||||.|.   |....:||:|||.:.|:.|.:..:..
  Rat   490 ADLAKVKKTLALEIINFKQP-----QSHETALHCAVASLHPKRKQVAELLLRKGANVNEKNKDFM 549

  Fly   372 TPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRG 436
            ||||:|.::....|:|:|.:|||.::|....|.|.||.||..|.:.....||.:.:.|.:.:::|
  Rat   550 TPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG 614

  Fly   437 ETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKD 501
            .|    ||:.....:.:||            .:.||:    |..:||..:|.......:: |.|.
  Rat   615 FT----AAQMGNEAVQQIL------------SESTPI----RTSDVDYRLLEASKAGDLE-TVKQ 658

  Fly   502 MYTALHIAAK--EGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQ 564
            :.:..::..:  ||:..                    ||||..|.|..:.|.:.||...|||.|:
  Rat   659 LCSPQNVNCRDLEGRHS--------------------TPLHFAAGYNRVSVVEYLLHHGADVHAK 703

  Fly   565 GKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANA 629
            .|.|:.|||.||.|.:.:||.||:..|||.:.......||||.||.|.:.:|...||::||....
  Rat   704 DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTK 768

  Fly   630 ESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGL-----------------------TPM 671
            :::.|.|||.| .:||..:|.:|| ...||:...||.|.                       ||:
  Rat   769 KNRDGNTPLDL-VKEGDTDIQDLL-RGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPL 831

  Fly   672 HLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTP 736
            ||.|..:|:.|||.|.:.||:::...|.|..|||.|:.:|..::...|::....|:|.....:||
  Rat   832 HLAAGYNNLEVAEYLLERGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTP 896

  Fly   737 LHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVL------DSLKTITKEDETA 795
            ||:.||:|...:..|||.|.|:...:...|||||.:|......::|      ::|.|..|...|.
  Rat   897 LHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATV 961

  Fly   796 AAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDNMLSDQPYRYLTVDEMKSLGDDSLPIDVTRDE 860
            .:.|       :::|.:......:.|    ..||:..  |...|.|....:.||.:...:....|
  Rat   962 VSAS-------LISPASTPSCLSAAS----SIDNLTG--PLAELAVGGASNAGDGAAGAERKEGE 1013

  Fly   861 --RMDSNRMTQSAEYASGVPPTIGEEVISPHKTQVYGSSPKATVDGVYIANGSGHDEPPHVGRKL 923
              .:|.|        .|....::|.|    |...:: .:.:.|:|   :....||:|...:|
  Rat  1014 VAGLDMN--------ISQFLKSLGLE----HLRDIF-ETEQITLD---VLADMGHEELKEIG--- 1059

  Fly   924 SWKSFLVSFLVDARGGAMRGCRH---SGVRMIIPSRSTCQPTRVTCRYVKPQRTMHPPQLMEGEA 985
                      ::|.|.     ||   .||..::..:   |.|       .|..|.|  .:.:|..
  Rat  1060 ----------INAYGH-----RHKLIKGVERLLGGQ---QGT-------NPYLTFH--CVNQGTI 1097

  Fly   986 LASRVLELGPCSTKFIGPVVMEVPHFASLRGKEREIIILRSDNGET---WREHTIDNSEEIIHDV 1047
            |    |:|.|           |...:.|:..:.:..|....|.|..   :..:.:...:::::..
  Rat  1098 L----LDLAP-----------EDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKK 1147

  Fly  1048 LQQ--CFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSRIRQEVHAIGPEGGMVSSTV 1104
            |::  |...:|::  ||...:|..|.:.:..|...|::.:...|.||.  .|||..:.:
  Rat  1148 LRERFCHRQKEVS--EENHNHHNERMLFHGSPFINAIIHKGFDERHAY--IGGMFGAGI 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	8/24 (33%)
		Ank_4	11..64	CDD:290365	16/52 (31%)
		ANK	38..163	CDD:238125	41/129 (32%)
		ANK repeat	43..74	CDD:293786	11/35 (31%)
		Ank_2	48..135	CDD:289560	33/86 (38%)
		ANK repeat	76..107	CDD:293786	13/30 (43%)
		ANK repeat	109..134	CDD:293786	8/24 (33%)
		Ank_4	110..163	CDD:290365	15/52 (29%)
		Ank_4	172..225	CDD:290365	15/52 (29%)
		ANK repeat	175..202	CDD:293786	6/26 (23%)
		ANK	199..324	CDD:238125	42/150 (28%)
		ANK repeat	204..235	CDD:293786	14/30 (47%)
		Ank_2	209..300	CDD:289560	34/90 (38%)
		ANK repeat	237..268	CDD:293786	10/30 (33%)
		ANK	266..390	CDD:238125	39/152 (26%)
		ANK repeat	270..300	CDD:293786	11/29 (38%)
		ANK repeat	303..367	CDD:293786	20/92 (22%)
		Ank_2	308..399	CDD:289560	30/119 (25%)
		ANK	364..489	CDD:238125	35/124 (28%)
		ANK repeat	369..400	CDD:293786	12/30 (40%)
		ANK repeat	402..433	CDD:293786	10/30 (33%)
		Ank_4	403..456	CDD:290365	15/52 (29%)
		ANK repeat	435..466	CDD:293786	6/30 (20%)
		Ank_2	440..530	CDD:289560	14/91 (15%)
		ANK	463..588	CDD:238125	34/126 (27%)
		ANK repeat	468..497	CDD:293786	6/28 (21%)
		ANK repeat	501..530	CDD:293786	2/30 (7%)
		Ank_2	506..597	CDD:289560	30/92 (33%)
		ANK	529..654	CDD:238125	49/124 (40%)
		ANK repeat	535..565	CDD:293786	13/29 (45%)
		ANK repeat	567..598	CDD:293786	14/30 (47%)
		Ank_2	572..661	CDD:289560	36/88 (41%)
		ANK repeat	600..630	CDD:293786	12/29 (41%)
		ANK repeat	633..662	CDD:293786	12/28 (43%)
		ANK	661..785	CDD:238125	44/152 (29%)
		ANK repeat	666..697	CDD:293786	13/53 (25%)
		Ank_2	672..762	CDD:289560	32/89 (36%)
		ANK repeat	699..730	CDD:293786	9/30 (30%)
		ANK repeat	732..762	CDD:293786	12/29 (41%)
		ZU5	927..1030	CDD:128514	20/105 (19%)
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
Tnks	NP_001099554.2	ANK	198..312	CDD:238125	39/113 (35%)
		ANK repeat	208..236	CDD:293786	11/27 (41%)
		Ank_2	210..302	CDD:289560	34/91 (37%)
		ANK repeat	238..269	CDD:293786	13/30 (43%)
		ANK	266..445	CDD:238125	56/186 (30%)
		ANK repeat	271..302	CDD:293786	10/30 (33%)
		Ank_4	329..379	CDD:290365	15/52 (29%)
		ANK repeat	361..389	CDD:293786	14/27 (52%)
		Ank_2	363..455	CDD:289560	34/91 (37%)
		ANK repeat	391..422	CDD:293786	10/30 (33%)
		ANK repeat	424..455	CDD:293786	11/30 (37%)
		ANK	513..629	CDD:238125	39/119 (33%)
		ANK repeat	513..545	CDD:293786	13/31 (42%)
		Ank_2	516..609	CDD:289560	33/92 (36%)
		ANK repeat	547..578	CDD:293786	12/30 (40%)
		ANK repeat	580..609	CDD:293786	10/28 (36%)
		Ank_2	585..704	CDD:289560	37/159 (23%)
		ANK	666..791	CDD:238125	50/145 (34%)
		ANK repeat	676..704	CDD:293786	13/27 (48%)
		Ank_2	678..770	CDD:289560	38/91 (42%)
		ANK repeat	706..737	CDD:293786	14/30 (47%)
		ANK repeat	739..770	CDD:293786	12/30 (40%)
		Ank_4	793..847	CDD:290365	14/53 (26%)
		ANK	819..943	CDD:238125	40/123 (33%)
		ANK repeat	826..857	CDD:293786	12/30 (40%)
		Ank_2	831..923	CDD:289560	32/91 (35%)
		ANK repeat	859..890	CDD:293786	9/30 (30%)
		ANK repeat	892..923	CDD:293786	12/30 (40%)
		SAM_tankyrase1,2	1014..1079	CDD:188923	18/98 (18%)
		SAM	1020..1077	CDD:197735	17/90 (19%)
		tankyrase_like	1081..1303	CDD:238718	30/150 (20%)
		PARP	1095..1298	CDD:279038	25/127 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810