DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and ANK1

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:XP_011542792.1 Gene:ANK1 / 286 HGNCID:492 Length:1969 Species:Homo sapiens


Alignment Length:2114 Identity:869/2114 - (41%)
Similarity:1226/2114 - (57%) Gaps:305/2114 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 QGDGNTSFLRAARAGNLERVLEHLKNNIDINTSN------------------------------- 41
            :.|..||||||||:|||::.|:||:|.:||||.|                               
Human    42 KADAATSFLRAARSGNLDKALDHLRNGVDINTCNQGPSASAVDLLLRCRISQSTGLLRVLYNQNR 106

  Fly    42 -ANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNV 105
             .||||.||||||:||:.:|.|||.:..|:::.|||||||||||:||||:|||:.|:.:.|:||.
Human   107 KKNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 171

  Fly   106 QSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGK 170
            |||.|||||||||||||..||:.||.|||||::||||||||||||:||||:.|||.|:...|:||
Human   172 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 236

  Fly   171 VRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSA 235
            ||||||||||:.||.:.|.:||.||.||||.||:||||||||:||.|.|:|.||:.:||.||::.
Human   237 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 301

  Fly   236 KHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAK 300
            ::.|:|||:|::.|...||.|||::|..||.||:|.|||||||||:||.::.::||:.||||.||
Human   302 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 366

  Fly   301 TKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANA 365
            |||||:|:||||||:|:|..|:||.:.|.:|::|:|:||.|||||||||.||||:|||:.|..|:
Human   367 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 431

  Fly   366 RALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPD 430
            ||||||||||||||||.::|:||||:.||||.|.|||||||||||:|||.:.||..|||..|||:
Human   432 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 496

  Fly   431 VPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQV 495
            |..|:.|||||:||||..|::.:.||:|.|:|:|:|::.|||||.|:|:|:.::|.|||::.|..
Human   497 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 561

  Fly   496 DATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEAD 560
            :..|...:|.|||||:||..|....|:|..|:....|||||||||:.||||.::||:|||:::|.
Human   562 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 626

  Fly   561 VDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGA 625
            .:|.||||:||||||.|:||..:..|||.:|.|||:.|.||:|||||||::||:::|.:||:||.
Human   627 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGG 691

  Fly   626 LANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNG 690
            .|||||..|.|||||::||||||:..||:..:|..|...|:||||:||.|||.:|.||::|.|:|
Human   692 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 756

  Fly   691 ANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEH 755
            ..:|..|:.||||||||||:|...:|:||||:.|:|:|.|.:||:||||.|||||..||.|||::
Human   757 VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 821

  Fly   756 KANANAQTVNGQTPLHIARKLGYISVLDSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESFMSD 820
            .|:.|..:.:|.|||.||::||||||.|.||.:|  |||:..  ...:|:|:..||.:.| .:..
Human   822 GASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVT--DETSFV--LVSDKHRMSFPETVDE-ILDV 881

  Fly   821 SEEEGGEDNMLSDQPYRYLTVDEMKSLGDDSLPIDVTRDERMDSNRMTQSAEYASGVPPTIGEEV 885
            ||:||          ..::|:     :|::.:..   :.||.||..:.:..|....| |.:.:.|
Human   882 SEDEG----------TAHITI-----MGEELISF---KAERRDSRDVDEEKELLDFV-PKLDQVV 927

  Fly   886 ISPHKTQVYGSSPKATVDGVYIAN------GSGHDE---------------------PPHVGRKL 923
            .||...::    |.|..:.|.|.:      ...:||                     |.|.|   
Human   928 ESPAIPRI----PCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTG--- 985

  Fly   924 SWKSFLVSFLVDARGGAMRGCRHSGVRMIIPSRSTCQPTRVTCRYVKPQRTMHPPQLMEGEALAS 988
                |||||:||||||:|||.||:|:|::||.|:...|||:|||.||||:...||.|.|.|.|||
Human   986 ----FLVSFMVDARGGSMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLAS 1046

  Fly   989 RVLELGPCSTKFIGPVVMEVPHFASLRGKEREIIILRSDNGETWREHTIDNSEEIIHDVLQQCFE 1053
            |::.|||...:|:.||::|:|||||....:||:::|||:||..|:||.....|..:..:|...  
Human  1047 RIIALGPTGAQFLSPVIVEIPHFASHGRGDRELVVLRSENGSVWKEHRSRYGESYLDQILNGM-- 1109

  Fly  1054 PEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSRIRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALT 1118
            .||:..|||.....|||.:|.|||.||.::||:.|:...||||||.:.|.:||.|||.||:.|:|
Human  1110 DEELGSLEELEKKRVCRIITTDFPLYFVIMSRLCQDYDTIGPEGGSLKSKLVPLVQATFPENAVT 1174

  Fly  1119 KKIKVGLQAQPVDPDLTAKLLGRGVAVSPIVTVEPRRRKFHKAITLSMPAPKAHSQGMINQYSGN 1183
            |::|:.||||||..:|..||||.....||||||||||||||:.|.|.:|.|.:.:....:...|:
Human  1175 KRVKLALQAQPVPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGD 1239

  Fly  1184 TPTLRLLCSITGGPSRAQWEDVTGSTPLTFVNDCVSFTTTVSARFWLMDCRNISDATKMATELYK 1248
            |.:||||||:.||..:|||||:||:|.|.:.|:|.:|||.|||||||.||...::|...||.|||
Human  1240 TTSLRLLCSVIGGTDQAQWEDITGTTKLVYANECANFTTNVSARFWLSDCPRTAEAVNFATLLYK 1304

  Fly  1249 EVIHVPFIAKFVVFAKKVEPFEAKLRVFCMTDDREDKTLEKHELYTEVAKSRDVEVLEGKPQYIE 1313
            |:..||::||||:|||..:|.|.:||.:|||||:.|||||:||.:.|||:|||:|||||...:.|
Human  1305 ELTAVPYMAKFVIFAKMNDPREGRLRCYCMTDDKVDKTLEQHENFVEVARSRDIEVLEGMSLFAE 1369

  Fly  1314 MAGNLVPVTKSGDQLQVQFKAFRENRLPFTVRVKDQHADIVGRTLFMKEPKVAKGEPPQQPICIL 1378
            ::||||||.|:..|....|::||||||...|:|:|...:..|...|::  |..|.|..|..:|.|
Human  1370 LSGNLVPVKKAAQQRSFHFQSFRENRLAMPVKVRDSSREPGGSLSFLR--KAMKYEDTQHILCHL 1432

  Fly  1379 NIVLPEAVIPDSTTAFSDR----VTSAYRTSMF------SLSKHQNDHYIGDIRIVDLSNLLGKD 1433
            ||.:|...   ..:...||    ...|.|.|:.      |||..:.    .::::..:|..||..
Human  1433 NITMPPCA---KGSGAEDRRRTPTPLALRYSILSESTPGSLSGTEQ----AEMKMAVISEHLGLS 1490

  Fly  1434 WIQLAPEIGINGEEIDEIINQNTDSIARQAQSMIRLY--KDKPNYDILSLETALKNIGRDDIMKK 1496
            |.:||.|:..:.|:|:.|..:|.:|:..|:.:::.|:  ::..|.::.:|.|||::|.|.:|:..
Human  1491 WAELARELQFSVEDINRIRVENPNSLLEQSVALLNLWVIREGQNANMENLYTALQSIDRGEIVNM 1555

  Fly  1497 CK-SGRLSHSREFDEADLMKNSESVEELVRRESKRIQQINEREEVKYSAEEKEVEESESDEEAAK 1560
            .: |||.|.:.:.|               ||.:.|...::..:...||:.:.|:....|...|..
Human  1556 LEGSGRQSRNLKPD---------------RRHTDRDYSLSPSQMNGYSSLQDELLSPASLGCALS 1605

  Fly  1561 RTVAERREKIVKRLSIERSIPASTQKKEITREITEIKRKSLIEDKKAHHESEILMQLPADNVIIK 1625
            ..:  |.::....:::..:||.:..:.:...|:::                   ||:.:..:...
Human  1606 SPL--RADQYWNEVAVLDAIPLAATEHDTMLEMSD-------------------MQVWSAGLTPS 1649

  Fly  1626 TTTVPDQVIKMKMGKMDSTEVSKSEFDKELTHKFKTSGRSSEEEDQPSYPDQTDKIVQDISAAEK 1690
            ..|..|          .|.|.||:|......|::|..|..|||...|           ::.:.|.
Human  1650 LVTAED----------SSLECSKAEDSDATGHEWKLEGALSEEPRGP-----------ELGSLEL 1693

  Fly  1691 KEKDGVTFSRVTTITRQEARDITEDFLEIE--KRSQ--LPATSTTATVHEKFVEEIKEKTSPLAS 1751
            .|.|.|.         .:|.:...|.||.|  :||:  ||.:               ::......
Human  1694 VEDDTVD---------SDATNGLIDLLEQEEGQRSEEKLPGS---------------KRQDDATG 1734

  Fly  1752 VPQETVKEVQQV---------------ISEVTEIASKKVENIISSFESSKSVDATTVLPTQPSVE 1801
            ..|::..||..|               :|:|||.:..:     ..|::          ||..|..
Human  1735 AGQDSENEVSLVSGHQRGQARITHSPTVSQVTERSQDR-----QLFQA----------PTPRSSG 1784

  Fly  1802 STKVSE------TIKNLEDAKAVSAEQVKT--VHVVE-SSSIEETI-----AEFEAKKVKYDFHG 1852
            ..::.:      .:..|:||...|.::..|  .|..: :|::.|.:     .|:|...|....| 
Human  1785 LVRLQDWDADGSIVSYLQDAAQGSWQEEVTQGPHSFQGTSTMTEGLEPGGSQEYEKVLVSVSEH- 1848

  Fly  1853 GEPKTQIPKFTRKPSDDSMKPTAAPRATVESETESVLETKAEKPISKIPVKTIPTEAQKVSEVDA 1917
                    .:|.:|..:|.:.....|.  :.:.|.|.|.|             .|..|.|...:.
Human  1849 --------TWTEQPEAESSQADRDRRQ--QGQEEQVQEAK-------------NTFTQVVQGNEF 1890

  Fly  1918 RKITQDFLQGEKLAAEPKPSPAASKIPKVEPRKSVDKQVDRESKILDDVVASTATIMTAGLGDEQ 1982
            :.|     .||::..|.......:.:.|...||.| :|:|..|                      
Human  1891 QNI-----PGEQVTEEQFTDEQGNIVTKKIIRKVV-RQIDLSS---------------------- 1927

  Fly  1983 LKDQLVDHSEIIAKSETVAEKVTEL---LDTFHK 2013
             .|...:|.|:..  |...|..:||   :|.|.|
Human  1928 -ADAAQEHEEVTV--EGPLEDPSELEVDIDYFMK 1958

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786 20/30 (67%)
Ank_4 11..64 CDD:290365 34/84 (40%)
ANK 38..163 CDD:238125 86/156 (55%)
ANK repeat 43..74 CDD:293786 17/30 (57%)
Ank_2 48..135 CDD:289560 57/86 (66%)
ANK repeat 76..107 CDD:293786 20/30 (67%)
ANK repeat 109..134 CDD:293786 18/24 (75%)
Ank_4 110..163 CDD:290365 41/52 (79%)
Ank_4 172..225 CDD:290365 36/52 (69%)
ANK repeat 175..202 CDD:293786 17/26 (65%)
ANK 199..324 CDD:238125 74/124 (60%)
ANK repeat 204..235 CDD:293786 19/30 (63%)
Ank_2 209..300 CDD:289560 49/90 (54%)
ANK repeat 237..268 CDD:293786 14/30 (47%)
ANK 266..390 CDD:238125 82/123 (67%)
ANK repeat 270..300 CDD:293786 18/29 (62%)
ANK repeat 303..367 CDD:293786 39/63 (62%)
Ank_2 308..399 CDD:289560 60/90 (67%)
ANK 364..489 CDD:238125 78/124 (63%)
ANK repeat 369..400 CDD:293786 23/30 (77%)
ANK repeat 402..433 CDD:293786 21/30 (70%)
Ank_4 403..456 CDD:290365 31/52 (60%)
ANK repeat 435..466 CDD:293786 16/30 (53%)
Ank_2 440..530 CDD:289560 40/89 (45%)
ANK 463..588 CDD:238125 62/124 (50%)
ANK repeat 468..497 CDD:293786 13/28 (46%)
ANK repeat 501..530 CDD:293786 12/28 (43%)
Ank_2 506..597 CDD:289560 51/90 (57%)
ANK 529..654 CDD:238125 75/124 (60%)
ANK repeat 535..565 CDD:293786 17/29 (59%)
ANK repeat 567..598 CDD:293786 18/30 (60%)
Ank_2 572..661 CDD:289560 51/88 (58%)
ANK repeat 600..630 CDD:293786 18/29 (62%)
ANK repeat 633..662 CDD:293786 15/28 (54%)
ANK 661..785 CDD:238125 70/123 (57%)
ANK repeat 666..697 CDD:293786 16/30 (53%)
Ank_2 672..762 CDD:289560 51/89 (57%)
ANK repeat 699..730 CDD:293786 19/30 (63%)
ANK repeat 732..762 CDD:293786 18/29 (62%)
ZU5 927..1030 CDD:128514 58/102 (57%)
Death_ank 1417..1497 CDD:260029 22/81 (27%)
ER-remodelling 11936..>12013 CDD:258892
ANK1XP_011542792.1 ANK 47..163 CDD:238125 55/115 (48%)
ANK repeat 47..75 CDD:293786 19/27 (70%)
ANK 108..229 CDD:238125 83/120 (69%)
ANK repeat 109..140 CDD:293786 17/30 (57%)
Ank_2 114..204 CDD:289560 60/89 (67%)
ANK repeat 143..173 CDD:293786 19/29 (66%)
ANK 170..324 CDD:238125 100/153 (65%)
ANK repeat 175..206 CDD:293786 22/30 (73%)
ANK repeat 208..232 CDD:293786 17/23 (74%)
ANK repeat 241..268 CDD:293786 17/26 (65%)
Ank_2 242..333 CDD:289560 51/90 (57%)
ANK 265..390 CDD:238125 74/124 (60%)
ANK repeat 271..301 CDD:293786 19/29 (66%)
ANK repeat 303..334 CDD:293786 14/30 (47%)
Ank_2 308..397 CDD:289560 52/88 (59%)
ANK repeat 336..367 CDD:293786 19/30 (63%)
ANK repeat 369..400 CDD:293786 17/30 (57%)
Ank 402..432 CDD:278452 21/29 (72%)
ANK repeat 405..433 CDD:293786 19/27 (70%)
ANKYR 406..619 CDD:223738 126/212 (59%)
ANK 430..555 CDD:238125 78/124 (63%)
ANK repeat 435..466 CDD:293786 23/30 (77%)
ANK repeat 468..499 CDD:293786 21/30 (70%)
ANK repeat 501..532 CDD:293786 16/30 (53%)
ANK 529..654 CDD:238125 62/124 (50%)
ANK repeat 534..563 CDD:293786 13/28 (46%)
ANK repeat 568..598 CDD:293786 12/29 (41%)
ANK repeat 600..631 CDD:293786 18/30 (60%)
Ank_2 605..696 CDD:289560 52/90 (58%)
ANK repeat 633..661 CDD:293786 16/27 (59%)
ANK repeat 666..697 CDD:293786 19/30 (63%)
ANK 666..695 CDD:197603 17/28 (61%)
ANK 694..819 CDD:238125 72/124 (58%)
ANK repeat 699..730 CDD:293786 16/30 (53%)
Ank_2 704..795 CDD:289560 49/90 (54%)
ANK repeat 732..763 CDD:293786 16/30 (53%)
ANK repeat 765..796 CDD:293786 19/30 (63%)
Ank_5 785..839 CDD:290568 29/53 (55%)
ANK repeat 798..826 CDD:293786 17/27 (63%)
ZU5 984..1088 CDD:128514 59/110 (54%)
Death_ank1 1474..1557 CDD:260067 22/86 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157944
Domainoid 1 1.000 277 1.000 Domainoid score I1734
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1011028at2759
OrthoFinder 1 1.000 - - FOG0000917
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100012
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.680

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