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Protein Alignment Ank2 and ANKRD52

DIOPT Version :10

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_775866.2	Gene:	ANKRD52 / 283373	HGNCID:	26614	Length:	1076	Species:	Homo sapiens

Alignment Length:	897	Identity:	258/897 - (28%)
Similarity:	381/897 - (42%)	Gaps:	130/897 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NGAQGDGNTSFLRAARAGNLERV-----------------------------LEHLK----NNID 36
            |.|...|.::...|..:|:||.|                             ||.||    ...|
Human   134 NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD 198

  Fly    37 INTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNA 101
            :...:..|...||.|:..|.|.||..|||.||.:|.....||||||||...||:.|...|:...|
Human   199 LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGA 263

  Fly   102 SVNVQSQNGFTPLYMAAQENHDAV-VRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLES 165
            :||..:..|||||::||...:.|: :.||::|||:.:..:::|.:|
Human   264 NVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSP------------------- 309

  Fly   166 DTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGAD 230
                      ||:||.......:.:|:.|....|...|.|.||||:|:.||::.:.:.|:..|||
Human   310 ----------LHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGAD 364

  Fly   231 VNYSAKHNISPLHVAAKWGKTNMVSLLLEKG----------------GNIEAKTRD--GLTPLHC 277
            ......|::.|||:|..:|.::....||..|                ...:..|.|  |.|.||.
Human   365 TARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHA 429

  Fly   278 AARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTVDYLTALH 342
            ||..|:.:.:::||..||.:..:.|.|..|||.||.......|..|:...|.|:|......:.||
Human   430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLH 494

  Fly   343 VAAHCGHVRVA----------------------------KLLLDRNADANARALNGFTPLHIACK 379
            .||.....|.|                            :.|||..||.:.|...|:|.:|.|..
Human   495 YAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAA 559

  Fly   380 KNRLKVVELLLRHGASISATTESGL--TPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHL 442
            ....:.:||||....:.....||.:  :|||:||:.|....:..|.:...:.||...:|.|.|.|
Human   560 YGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFL 624

  Fly   443 AARANQTDIIRILLRNGAQVDARAREQQ-TPLHIASRLGNVDIVMLLLQHGAQVDAT-TKDMY-- 503
            |.....|:.:.:|..:||....:.|::: ||||.|:..|:.|.:.||:..|.:.|.| ..|.|
Human   625 ATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQ 689

  Fly   504 TALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNG 568
            |.|.:|...|..:...:|:|.|:..|||..:|.|.||..|..|.......||..:|.|..:...|
Human   690 TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKG 754

  Fly   569 VTPLHVACHYNNQQVALLLLEKGASPH----ATAKNGHTPLHIAARKNQMDIATTLLEYGALANA 629
            .||:|:|....:..|...||:...|..    ....:|::|:|.|:.....|....|||:...:..
Human   755 RTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYL 819

  Fly   630 ESKAGFTPLHLSSQEGHAEISNLLIEHKAA--VNHPAKNGLTPMHLCAQEDNVNVAEILEKNGAN 692
            |... |||||.:........:.:|:....|  ||.....|.||:|..|..|||:...:|.::.|.
Human   820 EGNP-FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAE 883

  Fly   693 IDMATKAGYTPLHVASHFGQANMVRFLLQNG-ANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHK 756
            ::.....|.|.|..|:..||...|.|||..| |::........|.||....:||.....::|...
Human   884 VNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAET 948

  Fly   757 AN---ANAQTVNGQTPLHIARKLGYISVLDSL----KTITKEDETAAAPSQA 801
            .:   .||.....|.|||||.:.|..||:.:|    .|:...||....|:.|
Human   949 QDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALA 1000

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.