DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank2 and Sowahc

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_766527.3	Gene:	Sowahc / 268301	MGIID:	3606051	Length:	512	Species:	Mus musculus

Alignment Length:	157	Identity:	46/157 - (29%)
Similarity:	74/157 - (47%)	Gaps:	36/157 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 YTALHIAAKEGQDEVAAVLIENGAA-------LDAATKKGFTPLHLTAKYGHIKVAQLLL-QKEA 559
            :|.||.|||.|:.|:.|:|: |.|.       ::|.:..|:|.|||.|.:||::|.:||: ..:|
Mouse   290 FTCLHWAAKHGRQELLAMLV-NFATKHQLPVNINAKSSGGYTALHLAAMHGHVEVVKLLVGAYDA 353

  Fly   560 DVDAQGKNGVTPLHVACHYNNQQVA--------LLLLEKGASPHATAKNGH-------TPLHIAA 609
            |||.:..:|    ..|..|.::.:|        .|..:.|.||  .|:.|.       .|.||..
Mouse   354 DVDIRDYSG----RKASQYLSESIAEEIKNLVGALDEDDGDSP--AARGGGRWRLSKVLPSHITH 412

  Fly   610 RKNQMDIATTLLEYGALANAESKAGFT 636
            :      .:.::|.||..:.....|:|
Mouse   413 K------LSPVVEDGAELHHHVPEGWT 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786
		Ank_4	11..64	CDD:290365
		ANK	38..163	CDD:238125
		ANK repeat	43..74	CDD:293786
		Ank_2	48..135	CDD:289560
		ANK repeat	76..107	CDD:293786
		ANK repeat	109..134	CDD:293786
		Ank_4	110..163	CDD:290365
		Ank_4	172..225	CDD:290365
		ANK repeat	175..202	CDD:293786
		ANK	199..324	CDD:238125
		ANK repeat	204..235	CDD:293786
		Ank_2	209..300	CDD:289560
		ANK repeat	237..268	CDD:293786
		ANK	266..390	CDD:238125
		ANK repeat	270..300	CDD:293786
		ANK repeat	303..367	CDD:293786
		Ank_2	308..399	CDD:289560
		ANK	364..489	CDD:238125
		ANK repeat	369..400	CDD:293786
		ANK repeat	402..433	CDD:293786
		Ank_4	403..456	CDD:290365
		ANK repeat	435..466	CDD:293786
		Ank_2	440..530	CDD:289560	12/33 (36%)
		ANK	463..588	CDD:238125	33/100 (33%)
		ANK repeat	468..497	CDD:293786
		ANK repeat	501..530	CDD:293786	12/33 (36%)
		Ank_2	506..597	CDD:289560	35/106 (33%)
		ANK	529..654	CDD:238125	34/124 (27%)
		ANK repeat	535..565	CDD:293786	15/30 (50%)
		ANK repeat	567..598	CDD:293786	8/38 (21%)
		Ank_2	572..661	CDD:289560	17/80 (21%)
		ANK repeat	600..630	CDD:293786	7/36 (19%)
		ANK repeat	633..662	CDD:293786	2/4 (50%)
		ANK	661..785	CDD:238125
		ANK repeat	666..697	CDD:293786
		Ank_2	672..762	CDD:289560
		ANK repeat	699..730	CDD:293786
		ANK repeat	732..762	CDD:293786
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
Sowahc	NP_766527.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..248
		Ank_2	259..359	CDD:289560	28/69 (41%)
		ANK	288..397	CDD:238125	37/113 (33%)
		ANK 1	288..317		12/27 (44%)
		ANK repeat	289..325	CDD:293786	13/35 (37%)
		ANK repeat	327..359	CDD:293786	15/31 (48%)
		ANK 2	327..357		14/29 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..500		2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030