DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ank2 and Tnks

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:NP_780300.2 Gene:Tnks / 21951 MGIID:1341087 Length:1320 Species:Mus musculus


Alignment Length:1189 Identity:315/1189 - (26%)
Similarity:496/1189 - (41%) Gaps:223/1189 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 AQGDGNTSFLRAARA----------GNLERVLEHLKNN--------IDINTSNANGL-----NAL 48
            |.|.|:|:.|.|..|          |.|..:||..:|.        :|....||..:     :.|
Mouse   149 AAGVGSTATLGAGAAGLGPGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPL 213

  Fly    49 HLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTP 113
            |.|:..|...||..||:.||.|.:....|...||.|...|..|||.|||...|..|.:....:||
Mouse   214 HFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTP 278

  Fly   114 LYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHI 178
            |:.||.:....|..:||.:||:.::...||.:.|.:|     |.....:|..:.:....|.|   
Mouse   279 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA-----DPSAKAVLTGEYKKDELLEA--- 335

  Fly   179 AAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLH 243
            |...::.|...||...:.|...:.....||||:|:.|....|..||:|.||||:...|..:.|||
Mouse   336 ARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLH 400

  Fly   244 VAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPL 308
            .|..:|...:..|||:.|..:.|......||||.||.....:|..:||..||..:....:|.:.:
Mouse   401 NACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 465

  Fly   309 HMAAQGE-------------------HVDAARI-------LLYHRAPVDEVTVDYLTALHVAA-- 345
            .||...|                   ..|.|::       ::..:.|     ..:.||||.|.  
Mouse   466 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQP-----QSHETALHCAVAS 525

  Fly   346 -HCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHV 409
             |....:||:|||.:.|:.|.:..:..||||:|.::....|:|:|.:|||.::|....|.|.||.
Mouse   526 LHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDSLGQTALHR 590

  Fly   410 AAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLH 474
            ||..|.:.....||.:.:.|.:.:::|.|...:...|.|..:........:.||.|..|      
Mouse   591 AALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPMRTSDVDYRLLE------ 649

  Fly   475 IASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDAATKKGFTPL 539
             ||:.|:::.|..|.   :..:...:|:         ||:..                    |||
Mouse   650 -ASKAGDLETVKQLC---SPQNVNCRDL---------EGRHS--------------------TPL 681

  Fly   540 HLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTP 604
            |..|.|..:.|.:.||...|||.|:.|.|:.|||.||.|.:.:||.||:..|||.:.......||
Mouse   682 HFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTP 746

  Fly   605 LHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGL- 668
            ||.||.|.:.:|...||::||....:::.|.|||.| .:||..:|.:|| ...||:...||.|. 
Mouse   747 LHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLL-RGDAALLDAAKKGCL 809

  Fly   669 ----------------------TPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFG 711
                                  ||:||.|..:|:.|||.|.::||:::...|.|..|||.|:.:|
Mouse   810 ARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYG 874

  Fly   712 QANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKL 776
            ..::...|::....|:|.....:||||:.||:|...:..|||.|.|:...:...|||||.:|...
Mouse   875 HVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 939

  Fly   777 GYISVL------DSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDNMLSDQP 835
            ...::|      ::|.|..|...|..:.|       :::|.:......:.|    ..||:..  |
Mouse   940 DIRALLIDAMPPEALPTCFKPQATVVSAS-------LISPASTPSCLSAAS----SIDNLTG--P 991

  Fly   836 YRYLTVDEMKSLGDDSLPIDVTRDE--RMDSNRMTQSAEYASGVPPTIGEEVISPHKTQVYGSSP 898
            ...|.|....:.||.:...:....|  .:|.|        .|....::|.|    |...:: .:.
Mouse   992 LTDLAVGGASNAGDGAAGAERKEGEVAGLDMN--------ISQFLKSLGLE----HLRDIF-ETE 1043

  Fly   899 KATVDGVYIANGSGHDEPPHVGRKLSWKSFLVSFLVDARGGAMRGCRH---SGVRMIIPSRSTCQ 960
            :.|:|   :....||:|...:|             ::|.|.     ||   .||..::..:   |
Mouse  1044 QITLD---VLADMGHEELKEIG-------------INAYGH-----RHKLIKGVERLLGGQ---Q 1084

  Fly   961 PTRVTCRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKEREIIILR 1025
            .|       .|..|.|  .:.:|..|    |:|.|           |...:.|:..:.:..|...
Mouse  1085 GT-------NPYLTFH--CVNQGTIL----LDLAP-----------EDKEYQSVEEEMQSTIREH 1125

  Fly  1026 SDNGET---WREHTIDNSEEIIHDVLQQ--CFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSR 1085
            .|.|..   :..:.:...:::::..|::  |...:|::  ||...:|..|.:.:..|...|::.:
Mouse  1126 RDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVS--EENHNHHNERMLFHGSPFINAIIHK 1188

  Fly  1086 IRQEVHAIGPEGGMVSSTV 1104
            ...|.||.  .|||..:.:
Mouse  1189 GFDERHAY--IGGMFGAGI 1205

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786 11/48 (23%)
Ank_4 11..64 CDD:290365 19/75 (25%)
ANK 38..163 CDD:238125 41/129 (32%)
ANK repeat 43..74 CDD:293786 11/35 (31%)
Ank_2 48..135 CDD:289560 33/86 (38%)
ANK repeat 76..107 CDD:293786 13/30 (43%)
ANK repeat 109..134 CDD:293786 8/24 (33%)
Ank_4 110..163 CDD:290365 15/52 (29%)
Ank_4 172..225 CDD:290365 15/52 (29%)
ANK repeat 175..202 CDD:293786 6/26 (23%)
ANK 199..324 CDD:238125 42/150 (28%)
ANK repeat 204..235 CDD:293786 14/30 (47%)
Ank_2 209..300 CDD:289560 34/90 (38%)
ANK repeat 237..268 CDD:293786 10/30 (33%)
ANK 266..390 CDD:238125 39/152 (26%)
ANK repeat 270..300 CDD:293786 11/29 (38%)
ANK repeat 303..367 CDD:293786 20/92 (22%)
Ank_2 308..399 CDD:289560 30/119 (25%)
ANK 364..489 CDD:238125 35/124 (28%)
ANK repeat 369..400 CDD:293786 12/30 (40%)
ANK repeat 402..433 CDD:293786 10/30 (33%)
Ank_4 403..456 CDD:290365 14/52 (27%)
ANK repeat 435..466 CDD:293786 6/30 (20%)
Ank_2 440..530 CDD:289560 14/89 (16%)
ANK 463..588 CDD:238125 35/124 (28%)
ANK repeat 468..497 CDD:293786 6/28 (21%)
ANK repeat 501..530 CDD:293786 3/28 (11%)
Ank_2 506..597 CDD:289560 30/90 (33%)
ANK 529..654 CDD:238125 49/124 (40%)
ANK repeat 535..565 CDD:293786 13/29 (45%)
ANK repeat 567..598 CDD:293786 14/30 (47%)
Ank_2 572..661 CDD:289560 36/88 (41%)
ANK repeat 600..630 CDD:293786 12/29 (41%)
ANK repeat 633..662 CDD:293786 12/28 (43%)
ANK 661..785 CDD:238125 44/152 (29%)
ANK repeat 666..697 CDD:293786 13/53 (25%)
Ank_2 672..762 CDD:289560 32/89 (36%)
ANK repeat 699..730 CDD:293786 9/30 (30%)
ANK repeat 732..762 CDD:293786 12/29 (41%)
ZU5 927..1030 CDD:128514 20/105 (19%)
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
TnksNP_780300.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..88
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 111..152 1/2 (50%)
ANK 1 174..202 6/27 (22%)
ANK 201..315 CDD:238125 39/113 (35%)
ANK 2 208..237 11/28 (39%)
ANK repeat 211..239 CDD:293786 11/27 (41%)
Ank_2 213..305 CDD:289560 34/91 (37%)
ANK repeat 241..272 CDD:293786 13/30 (43%)
ANK 3 241..270 12/28 (43%)
ANK 269..448 CDD:238125 56/186 (30%)
ANK repeat 274..305 CDD:293786 10/30 (33%)
ANK 4 274..303 10/28 (36%)
Ank_4 332..382 CDD:290365 15/52 (29%)
ANK 5 361..390 14/28 (50%)
ANK repeat 364..392 CDD:293786 14/27 (52%)
Ank_2 366..458 CDD:289560 34/91 (37%)
ANK repeat 394..425 CDD:293786 10/30 (33%)
ANK 6 394..423 9/28 (32%)
ANK repeat 427..458 CDD:293786 11/30 (37%)
ANK 7 427..456 11/28 (39%)
ANK 8 514..546 12/31 (39%)
ANK 516..632 CDD:238125 39/115 (34%)
ANK repeat 516..548 CDD:293786 13/31 (42%)
Ank_2 519..612 CDD:289560 33/92 (36%)
ANK repeat 550..581 CDD:293786 12/30 (40%)
ANK 9 550..579 11/28 (39%)
ANK repeat 583..612 CDD:293786 10/28 (36%)
ANK 10 583..612 10/28 (36%)
Ank_2 588..707 CDD:289560 37/157 (24%)
ANK 669..794 CDD:238125 51/154 (33%)
ANK 11 676..705 12/48 (25%)
ANK repeat 679..707 CDD:293786 13/27 (48%)
Ank_2 681..773 CDD:289560 38/91 (42%)
ANK repeat 709..740 CDD:293786 14/30 (47%)
ANK 12 709..738 14/28 (50%)
ANK repeat 742..773 CDD:293786 12/30 (40%)
ANK 13 742..771 12/28 (43%)
ANK 14 775..803 12/29 (41%)
Ank_4 796..850 CDD:290365 14/53 (26%)
ANK 822..946 CDD:238125 40/123 (33%)
ANK repeat 829..860 CDD:293786 12/30 (40%)
ANK 15 829..858 12/28 (43%)
Ank_2 834..926 CDD:289560 32/91 (35%)
ANK repeat 862..893 CDD:293786 9/30 (30%)
ANK 16 862..891 8/28 (29%)
ANK repeat 895..926 CDD:293786 12/30 (40%)
ANK 17 895..924 12/28 (43%)
ANK 18 928..957 8/28 (29%)
SAM_tankyrase1,2 1017..1082 CDD:188923 18/98 (18%)
SAM 1023..1080 CDD:197735 17/90 (19%)
tankyrase_like 1084..1306 CDD:238718 30/150 (20%)
PARP 1098..1301 CDD:279038 25/127 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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