DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and Hace1

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	XP_006512697.1	Gene:	Hace1 / 209462	MGIID:	2446110	Length:	921	Species:	Mus musculus

Alignment Length:	528	Identity:	128/528 - (24%)
Similarity:	200/528 - (37%)	Gaps:	132/528 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 KAATLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYS-AKHNISPLHVAAKWG 249
            :|.|:.|..|:.   |:.....|:.:|..:  ::::.||.....||||: .:...|.||:||..|
Mouse    17 RARTVELPEDNE---TAVYTLMPMVMADQH--RSVSELLSNSKFDVNYAFGRVKRSLLHIAANCG 76

  Fly   250 KTNMVSLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQG 314
            ....:.|||:||.|...:...|.||||.|||:|.::.:..|||..|.::.....||..:|..|..
Mouse    77 SVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVN 141

  Fly   315 EHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACK 379
            ...:....|:.|...||.......||||||...||....:.|||..||.|...::|.|||:.||:
Mouse   142 GRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACR 206

  Fly   380 KNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAA 444
            :..|.....:..||...:|.                    |.||:  .:..:|...|.|||.|..
Mouse   207 RVCLIFWTWIHSHGQRDTAQ--------------------ILLLR--GAKYLPDKNGVTPLDLCV 249

  Fly   445 RANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDI----VMLLLQHGAQVDATTKDMYTA 505
            :........:|      :....|..||   |.....|.|:    :..:|||.:|
Mouse   250 QGGYGQTCEVL------IQYHPRLFQT---IVQMTQNEDLRENMLRQVLQHLSQ----------- 294

  Fly   506 LHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVT 570
                    |.|...:.|..|.| :.||..|...|.|::.|                |||.|:.:.
Mouse   295 --------QSESQYLKILTGLA-EVATTNGHKLLSLSSNY----------------DAQMKSLLR 334

  Fly   571 PLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAG- 634
            .:.:.||         :...|.|   :..||                   ::.|...|...::.
Mouse   335 IVRIFCH---------VFRIGPS---SPSNG-------------------IDMGYNGNKTPRSQV 368

  Fly   635 FTPLHL---SSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEI-LEKNGANIDM 695
            |.||.|   |..|....|:..|:::|                   ||:.::..| |::.|.:.:.
Mouse   369 FKPLELLWHSLDEWLVLIATELMKNK-------------------EDSTDITSILLKQKGQDQEA 414

  Fly   696 ATKAGYTP 703
            .:.:.:.|
Mouse   415 PSLSAFEP 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786
		Ank_4	11..64	CDD:290365
		ANK	38..163	CDD:238125
		ANK repeat	43..74	CDD:293786
		Ank_2	48..135	CDD:289560
		ANK repeat	76..107	CDD:293786
		ANK repeat	109..134	CDD:293786
		Ank_4	110..163	CDD:290365
		Ank_4	172..225	CDD:290365	8/38 (21%)
		ANK repeat	175..202	CDD:293786	4/15 (27%)
		ANK	199..324	CDD:238125	38/125 (30%)
		ANK repeat	204..235	CDD:293786	8/31 (26%)
		Ank_2	209..300	CDD:289560	32/91 (35%)
		ANK repeat	237..268	CDD:293786	12/30 (40%)
		ANK	266..390	CDD:238125	42/123 (34%)
		ANK repeat	270..300	CDD:293786	13/29 (45%)
		ANK repeat	303..367	CDD:293786	22/63 (35%)
		Ank_2	308..399	CDD:289560	29/90 (32%)
		ANK	364..489	CDD:238125	27/128 (21%)
		ANK repeat	369..400	CDD:293786	10/30 (33%)
		ANK repeat	402..433	CDD:293786	3/30 (10%)
		Ank_4	403..456	CDD:290365	9/52 (17%)
		ANK repeat	435..466	CDD:293786	6/30 (20%)
		Ank_2	440..530	CDD:289560	18/93 (19%)
		ANK	463..588	CDD:238125	27/128 (21%)
		ANK repeat	468..497	CDD:293786	9/32 (28%)
		ANK repeat	501..530	CDD:293786	5/28 (18%)
		Ank_2	506..597	CDD:289560	19/90 (21%)
		ANK	529..654	CDD:238125	25/128 (20%)
		ANK repeat	535..565	CDD:293786	6/29 (21%)
		ANK repeat	567..598	CDD:293786	4/30 (13%)
		Ank_2	572..661	CDD:289560	17/92 (18%)
		ANK repeat	600..630	CDD:293786	4/29 (14%)
		ANK repeat	633..662	CDD:293786	9/32 (28%)
		ANK	661..785	CDD:238125	6/44 (14%)
		ANK repeat	666..697	CDD:293786	5/31 (16%)
		Ank_2	672..762	CDD:289560	6/33 (18%)
		ANK repeat	699..730	CDD:293786	1/5 (20%)
		ANK repeat	732..762	CDD:293786
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
Hace1	XP_006512697.1	ANK repeat	66..95	CDD:293786	12/28 (43%)
		Ank_2	69..194	CDD:372319	46/124 (37%)
		ANK repeat	97..128	CDD:293786	13/30 (43%)
		ANK repeat	130..161	CDD:293786	8/30 (27%)
		ANK repeat	163..194	CDD:293786	14/30 (47%)
		Ank_2	168..263	CDD:372319	32/122 (26%)
		ANK repeat	196..233	CDD:293786	13/58 (22%)
		HECTc	566..915	CDD:238033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900