DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and trp-4

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_493429.2	Gene:	trp-4 / 190574	WormBaseID:	WBGene00006616	Length:	1924	Species:	Caenorhabditis elegans

Alignment Length:	1052	Identity:	290/1052 - (27%)
Similarity:	466/1052 - (44%)	Gaps:	256/1052 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVTENGAQGDGNTSFLRAARA---GNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSE 62
            |.:|:.|..|..|..|..|:.   .|:|..:|.:|.: |.:.::.:|..|..||.|.|...:|.:
Worm   308 MSSEDLAMADPQTKILYFAKRDEWANVESEIETIKRS-DFSMADNHGFTAFLLAVKAGKDQIVDK 371

  Fly    63 LLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTP-----LYMAAQENH 122
            ::|:||.||.:||.|..|.|||::....|.::|:|:..:.:   .:.|..|     :::|.:...
Worm   372 MIRKGARVDYSTKDGRNATHIAAMYSGVETLELILKRYSEL---LRKGAGPKKQLAIHVACERKS 433

  Fly   123 D---AVVRLLLSNGANQSLATE-DGFTPLAVAMQQGHDKVVAVLLESDTRGKVRL------PALH 177
            .   .:|:.:|.: .:|.:|.: ||..|:.:|.:.|:..:|.:||...:..:.|.      ..||
Worm   434 KKAFPIVKRILED-TDQRMAEDGDGSLPIHLAFKFGNVNIVELLLSGPSDEQTRKADGNGDTLLH 497

  Fly   178 IAAKKDDVKAA-TLLLDNDHNPDVTSKSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISP 241
            :||:..:::|. |.:.....|.:|.::.|.||||..:..|:||:..::.:..||.|...|.:.:|
Worm   498 LAARSGNIEAVRTAIAAGCDNANVQNRVGRTPLHEVAEVGDQNMLKIMFKLRADANIHDKEDKTP 562

  Fly   242 LHVAAKWGKTNMVSLLLEK-GGNIEAKTRDGLTPLHCAARSGH---------------------- 283
            :||||:.|.|:||..|::| ||:|.|:||||.|.||.||.|||
Worm   563 VHVAAERGDTSMVESLIDKFGGSIRARTRDGSTLLHIAACSGHTSTALAFLKRGVPLFMPNKKGA 627

  Fly   284 -----------EQVVDMLLERGAPISAKTKNGLAPLHMAAQ---------------------GE- 315
                       ..||.||:.||..:..:|::....||:|.|                     ||
Worm   628 LGLHSAAAAGFNDVVKMLIARGTNVDVRTRDNYTALHVAVQSGKASVVETLLGSGADIHVKGGEL 692

  Fly   316 -----HV----------DAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANA 365
                 |:          |.|.:||......|...:|..|.||:||..|:..:.:||||.|||:..
Worm   693 GQTALHIAASLNGAESRDCAMMLLKSGGQPDVAQMDGETCLHIAARSGNKDIMRLLLDENADSKI 757

  Fly   366 RALNGFTPLHIACKKNRLKVVELLLRHGAS----------ISATTESGLTPLHVAA--------F 412
            .:..|.|||.:|.|....:...::|:|.:.          ::..|..|.|.||.||        |
Worm   758 SSKIGETPLQVAAKSCNFEAASMILKHLSEVLTQEQLKEHVNHRTNDGFTALHYAAEIEQRQLHF 822

  Fly   413 MG-CMNIVIYLLQHDASPDVPTVR-GETPLHLAARA-NQ-------------------------- 448
            .| ...:|..|:.:....::|::. .||.:|:|||: ||
Worm   823 PGEDAKLVNLLIDYGGMVEMPSLNANETAMHMAARSGNQAVLLAMVNKIGAGAVQIVQNKQSKNG 887

  Fly   449 ------------TDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKD 501
                        :.:..|||::.|::|......:|.||:|:..|::.:|.|||||.|.|::.:|.
Worm   888 WSPLLEACARGHSGVANILLKHHARIDVFDEMGRTALHLAAFNGHLSLVHLLLQHKAFVNSKSKT 952

  Fly   502 MYTALHIAAKEGQDEVAAVLI-ENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQG 565
            ....||:||:.|..:|..||: ::||||:|.|....|.||..||:|.:.|:|.||...|:.:|:.
Worm   953 GEAPLHLAAQHGHVKVVNVLVQDHGAALEAITLDNQTALHFAAKFGQLAVSQTLLALGANPNARD 1017

  Fly   566 KNGVTPLHVACHYNNQQVALLLLEKGASPH----ATAKNGHTPLHIAARKNQMDIATTL--LEYG 624
            ..|.||||:|...:...|..|.|:...:..    |...||.|..||||.|..:.:...|  ::..
Worm  1018 DKGQTPLHLAAENDFPDVVKLFLKMRNNNRSVLTAIDHNGFTCAHIAAMKGSLAVVRELMMIDKP 1082

  Fly   625 ALANAESKA-GFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEK 688
            .:..|::|. ..|.||:::..|||.|..:|:|:.|.......:|:|.:||.|:...:::.|..:|
Worm  1083 MVIQAKTKTLEATTLHMAAAGGHANIVKILLENGANAEDENSHGMTALHLGAKNGFISILEAFDK 1147

  Fly   689 ----------------------------------------------NGANIDMATKAGYTPLHVA 707
                                                          :..|.:.:|:.|:||||:|
Worm  1148 ILWKRCSRKTGLNALHIAAFYGNSDFVNEMLKHVQATVRSEPPIYNHHVNKEFSTEYGFTPLHLA 1212

  Fly   708 SHFGQANMVRFLLQNGANVDAATSI-----------------------------------GYTPL 737
            :..|..::||.||..|..|||.::.                                   |.|||
Worm  1213 AQSGHDSLVRMLLNQGVQVDATSTTMNVIPLHLAAQQGHIAVVGMLLSRSTQQQHAKDWRGRTPL 1277

  Fly   738 HQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVL--------DSLKTITKEDET 794
            |..||.||..:|:||:...:|.|....||.|.||.|.:.|::||:        |.|.. |||.:.
Worm  1278 HLAAQNGHYEMVSLLIAQGSNINVMDQNGWTGLHFATRAGHLSVVKLFIDSSADPLAE-TKEGKV 1341

  Fly   795 ----AAAPSQAE 802
                |||.:..|
Worm  1342 PLCFAAAHNHIE 1353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	9/33 (27%)
		Ank_4	11..64	CDD:290365	15/55 (27%)
		ANK	38..163	CDD:238125	35/133 (26%)
		ANK repeat	43..74	CDD:293786	12/30 (40%)
		Ank_2	48..135	CDD:289560	25/94 (27%)
		ANK repeat	76..107	CDD:293786	8/30 (27%)
		ANK repeat	109..134	CDD:293786	5/32 (16%)
		Ank_4	110..163	CDD:290365	13/61 (21%)
		Ank_4	172..225	CDD:290365	17/59 (29%)
		ANK repeat	175..202	CDD:293786	8/27 (30%)
		ANK	199..324	CDD:238125	56/195 (29%)
		ANK repeat	204..235	CDD:293786	11/30 (37%)
		Ank_2	209..300	CDD:289560	42/124 (34%)
		ANK repeat	237..268	CDD:293786	15/31 (48%)
		ANK	266..390	CDD:238125	52/193 (27%)
		ANK repeat	270..300	CDD:293786	16/62 (26%)
		ANK repeat	303..367	CDD:293786	26/100 (26%)
		Ank_2	308..399	CDD:289560	34/137 (25%)
		ANK	364..489	CDD:238125	40/183 (22%)
		ANK repeat	369..400	CDD:293786	8/40 (20%)
		ANK repeat	402..433	CDD:293786	10/39 (26%)
		Ank_4	403..456	CDD:290365	20/101 (20%)
		ANK repeat	435..466	CDD:293786	13/70 (19%)
		Ank_2	440..530	CDD:289560	37/129 (29%)
		ANK	463..588	CDD:238125	49/125 (39%)
		ANK repeat	468..497	CDD:293786	13/28 (46%)
		ANK repeat	501..530	CDD:293786	12/29 (41%)
		Ank_2	506..597	CDD:289560	35/95 (37%)
		ANK	529..654	CDD:238125	42/131 (32%)
		ANK repeat	535..565	CDD:293786	12/29 (41%)
		ANK repeat	567..598	CDD:293786	10/34 (29%)
		Ank_2	572..661	CDD:289560	28/95 (29%)
		ANK repeat	600..630	CDD:293786	9/31 (29%)
		ANK repeat	633..662	CDD:293786	10/29 (34%)
		ANK	661..785	CDD:238125	48/212 (23%)
		ANK repeat	666..697	CDD:293786	8/76 (11%)
		Ank_2	672..762	CDD:289560	36/170 (21%)
		ANK repeat	699..730	CDD:293786	15/30 (50%)
		ANK repeat	732..762	CDD:293786	14/64 (22%)
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
trp-4	NP_493429.2	ANK repeat	804..842	CDD:293786	10/37 (27%)
		ANK repeat	849..884	CDD:293786	8/34 (24%)
		ANK repeat	886..917	CDD:293786	5/30 (17%)
		ANK repeat	919..950	CDD:293786	13/30 (43%)
		ANK repeat	952..982	CDD:293786	12/29 (41%)
		ANK repeat	986..1017	CDD:293786	12/30 (40%)
		PHA03095	1006..>1336	CDD:222980	84/330 (25%)
		ANK repeat	1092..1123	CDD:293786	10/30 (33%)
		ANK repeat	1204..1236	CDD:293786	15/31 (48%)
		trp	1209..1879	CDD:273311	44/146 (30%)
		ANK repeat	1238..1270	CDD:293786	0/31 (0%)
		ANK repeat	1272..1303	CDD:293786	14/30 (47%)
		ANK repeat	1305..1336	CDD:293786	11/31 (35%)
		ANK repeat	1338..1366	CDD:293786	5/16 (31%)
		ANKYR	280..515	CDD:223738	56/211 (27%)
		ANK repeat	352..383	CDD:293786	12/30 (40%)
		ANK repeat	385..418	CDD:293786	9/35 (26%)
		ANK repeat	424..454	CDD:293786	5/30 (17%)
		PHA03095	430..>756	CDD:222980	93/326 (29%)
		ANK repeat	456..489	CDD:293786	9/32 (28%)
		ANK repeat	491..523	CDD:293786	8/31 (26%)
		ANK repeat	526..556	CDD:293786	11/29 (38%)
		ANK repeat	558..590	CDD:293786	15/31 (48%)
		ANK repeat	592..623	CDD:293786	10/30 (33%)
		ANK repeat	625..656	CDD:293786	6/30 (20%)
		ANK repeat	658..688	CDD:293786	4/29 (14%)
		ANK repeat	692..726	CDD:293786	6/33 (18%)
		PHA02876	<712..>1040	CDD:165207	99/327 (30%)
		ANK repeat	728..753	CDD:293786	11/24 (46%)
		ANK repeat	761..802	CDD:293786	8/40 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53364at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820