DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and F26D2.10

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_507152.2	Gene:	F26D2.10 / 180104	WormBaseID:	WBGene00009149	Length:	1213	Species:	Caenorhabditis elegans

Alignment Length:	1345	Identity:	248/1345 - (18%)
Similarity:	431/1345 - (32%)	Gaps:	465/1345 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1581 PASTQ----KKEITREIT------------EIKRKSLIEDKKAHHESEILMQLPAD--NVIIKTT 1627
            ||:.|    |..|...:|            ||..:.||.:         |:.:|::  |.::..
Worm    26 PANLQLISEKFRILSRVTNAIYLQAGAIKNEINARELISE---------LLHMPSNQLNTVVNV- 80

  Fly  1628 TVPDQVIKMKMGKMDSTEVSKSEFDK------ELTHKFKTSGRSSEEEDQPSYPDQTDKIVQDIS 1686
                           :.||:.||..:      :|.|.|       |...|.|:.|..:.|..:|.
Worm    81 ---------------NVEVASSELRRMHQEYTKLIHFF-------ENRTQSSFNDDVNAIFNNII 123

  Fly  1687 AAEKKEKDGVTFSRVTTITRQ----EARDITEDFLEIEKRSQLPATSTTATVHEKFV-----EEI 1742
            ......:.....|.|::|:.:    |.:.|.:|.|       ..::.:..|..::||     :::
Worm   124 FILYFSRKSSLLSEVSSISTKNLLNETKSIAKDRL-------FNSSCSLLTGLDEFVALFDDDQL 181

  Fly  1743 KEKTSPLASVPQETVKEVQQVISEVTEIAS--KKVENIISSFESSKSVDATTVL----------- 1794
            ...:..:|.:    :.|..:..|.:||..|  ||::..|.:..:.|:|:|...|
Worm   182 TPNSEKIAQI----INEFHRQASLMTECISGLKKLDEDIDALSNWKNVEAYNKLWYVKDSIILFE 242

  Fly  1795 ----PTQPSVES----TKVSETIKNLEDAKAVSAEQVKTVHVVESSSIEETIAEFEAKKV----- 1846
                |.....||    ....:|.|.|.:::: |..|.|....:  :.:.::|.|.|...:
Worm   243 TFREPLSSWNESLLKILSAFQTAKPLWNSRS-SLGQSKIFEAM--AQLNKSIVEAEDHNISSINQ 304

  Fly  1847 --KY--------DFH--GGEPKTQ-IPKFTRKPSDDSMKPTAAPRATVESETESVLETK------ 1892
              ||        ||.  .|:.|:. ..||..|.||.....:|.......||....|::.
Worm   305 DLKYTAGFKNFGDFSKIAGDLKSAWFKKFLAKGSDTRALSSALQTFQNVSEKMDALDSSWSTLMR 369

  Fly  1893 -AEKPISKIPVKT-----IPTEAQKVSEVDARKITQDFLQGE---KLAAEPKPSPAASKIPKVE- 1947
             :||.:..|.:|.     :.|....:||:: |.|.:.....|   |......|:...::|...|
Worm   370 LSEKKMHPIGLKANFVADVATIGLNLSELE-RVIHESGKHIESCMKPLVRTTPNSFGNQIVNYET 433

  Fly  1948 ---PRKSVDKQVDRESKILDDVVASTATIMTAGLGDEQLKDQ----------LVDHSEIIAKSET 1999
               |..|:..::.....|:.: :.:|...||.  .:|||:|:          ::|..::.|.:..
Worm   434 FFFPAHSIMTRLSNVKDIIKE-LNTTLNFMTG--SNEQLRDRFHNRNRAVYSVLDQLQVNASNSI 495

  Fly  2000 VAEKVT------------ELLDTFH---KIEEKVTKSEKTSE---------ISSKVEELVKIEEK 2040
            :.:::.            |.|.|..   ||..::...:||:|         :...:..|..:|..
Worm   496 IVKRILRRKYKGIVVNSYEFLSTIKSIAKIASELQVVQKTAENITVSDGNILGDLISNLSLVETS 560

  Fly  2041 PLSQVQPKEDKVAEKVAEVIETFHKIEEKITTADARELTRDFLSMEQQNQLPSMPQAAEKPLESS 2105
            .......|.....|.....:::.....:..|.:...|.. |.|...|.|.     ...||.::||
Worm   561 KCFSQYYKTMPTLESTVSKLKSLRMFPDGETISTMLEYL-DLLGKVQSNL-----TLVEKEIKSS 619

  Fly  2106 LTSTSASEPESIVTVKPSPPASKIPVVEPRKIV--FDESTKPLIEPEPVKTTEKKPLNERQLTAD 2168
             ||...|....::.:|           .|:.::  ...||:.|.:.|.|:...:...:.|..|||
Worm   620 -TSHVNSTNNPVLLLK-----------TPQALIKNIGTSTRVLEDLENVRQHRQFLYSIRNFTAD 672

  Fly  2169 FLSMEQQTQLVSEPAKSLVEEVMKSAEQMVEQPKQQKSLNERQLTEDFLLMEQQTQLPSDIVKPT 2233
                              |::|: ..|.::|....:|.|.|        |:|:..||...    .
Worm   673 ------------------VKKVI-VGENLIEWIDPEKKLRE--------LLEEADQLNGF----A 706

  Fly  2234 DKLIDG-IESAAPVGDEASPFH----TPKLTTSVVTQEPQ-----QLASEYDSDTFGKQATIPLG 2288
            ..|.:| :...|.|.|||:...    .||...:|.....|     |||:   |..|.|...:.|.
Worm   707 GSLRNGSLTEMARVFDEAAKIKGIGGDPKSMANVSINLLQASGTDQLAA---SKVFRKIRELNLD 768

  Fly  2289 DSKIDQGLIAPVSMEPRKSLTDAEFCKSVGETITKKMSVGVIEISDEL------------KKIES 2341
            .:|.:..|                  ||...|:     :.:|...||:            |.|::
Worm   769 FAKHEASL------------------KSASVTV-----ISLIAYYDEIFGNSKSKILTIEKHIDN 810

  Fly  2342 EIP----------------------HSQTP---------------PPTPSDNK------TDKQNE 2363
            ..|                      :..|.               .|...:.:      .|.|:.
Worm   811 SFPWIYILLICIGSILLIGLFCVVAYGFTKNGRAKYTNLYLYYFGKPLDYERRWRYSLFLDNQDG 875

  Fly  2364 EPELISLERDYLADTV------------------TTLHTTTESTLERVSAITKIEH------FSV 2404
            :..|:...|:.....|                  |.||..|:|.|..:..|. |||      .:.
Worm   876 KNTLLDAVREINKTNVMKAVKLGSYITAYNKFGNTALHAATKSALPEIVKIL-IEHGADLTLLNT 939

  Fly  2405 HNVKSETFTRTDEPDKLLHSVVAPPDIQKLYSQ--------------DTTSF------------- 2442
            .|...|.....|.||.....:.....|:|||::              ..|||
Worm   940 LNKTPEQMIPLDSPDNSKDKIEKLEKIRKLYNKANGKKYKKCVPQKFPATSFHIWMDEITDNKIT 1004

  Fly  2443 ----------TEMSTSSQTPKMTTTTTMTAQIDRTKVDL---TIPGQDQQKQKDLKEQSAVVVDA 2494
                      |....:..|..:...|.....:|...:||   ...|....|:|       .::|.
Worm  1005 NDFMEKFQAITSDEAAPNTTHVIVKTDENGVLDTDNLDLLFWMFNGAIIVKEK-------WMIDC 1062

  Fly  2495 KAETEKTASDREYL-EQIMGCGDVRRKIMRLESSCSTESLESVGKSSTVTPKYIGDNVPVVREVV 2558
            ..:.:....|.:|| :.:...|...:.:::..        |::.|.:          :|.:..|.
Worm  1063 LNDEKLIEQDSKYLVDSVKYKGSTFKTVLQWS--------EAMAKGA----------IPYLYGVY 1109

  Fly  2559 QSMEDKIC------STVVSA--------IP----FTVQKRKPH---------------------- 2583
            .::..|.|      :|:|:|        .|    |.|..|..|
Worm  1110 TAIVMKECKNLLTLNTLVAAHGGVVMDTFPGKELFNVGSRPYHHANLGPLFLIHDGTINLNVYQS 1174

  Fly  2584 DDDK------EPNIVE--LEKQILTPADLALEKIFKCEPPSEVVK 2620
            |.||      |...::  ||:.|:  .|:       ||.|..|:|
Worm  1175 DPDKMYTLFTEAEFIKFMLERNIV--RDI-------CETPINVLK 1210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786
		Ank_4	11..64	CDD:290365
		ANK	38..163	CDD:238125
		ANK repeat	43..74	CDD:293786
		Ank_2	48..135	CDD:289560
		ANK repeat	76..107	CDD:293786
		ANK repeat	109..134	CDD:293786
		Ank_4	110..163	CDD:290365
		Ank_4	172..225	CDD:290365
		ANK repeat	175..202	CDD:293786
		ANK	199..324	CDD:238125
		ANK repeat	204..235	CDD:293786
		Ank_2	209..300	CDD:289560
		ANK repeat	237..268	CDD:293786
		ANK	266..390	CDD:238125
		ANK repeat	270..300	CDD:293786
		ANK repeat	303..367	CDD:293786
		Ank_2	308..399	CDD:289560
		ANK	364..489	CDD:238125
		ANK repeat	369..400	CDD:293786
		ANK repeat	402..433	CDD:293786
		Ank_4	403..456	CDD:290365
		ANK repeat	435..466	CDD:293786
		Ank_2	440..530	CDD:289560
		ANK	463..588	CDD:238125
		ANK repeat	468..497	CDD:293786
		ANK repeat	501..530	CDD:293786
		Ank_2	506..597	CDD:289560
		ANK	529..654	CDD:238125
		ANK repeat	535..565	CDD:293786
		ANK repeat	567..598	CDD:293786
		Ank_2	572..661	CDD:289560
		ANK repeat	600..630	CDD:293786
		ANK repeat	633..662	CDD:293786
		ANK	661..785	CDD:238125
		ANK repeat	666..697	CDD:293786
		Ank_2	672..762	CDD:289560
		ANK repeat	699..730	CDD:293786
		ANK repeat	732..762	CDD:293786
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
F26D2.10	NP_507152.2	WSN	28..95	CDD:197734	15/91 (16%)
		Ank_2	<870..938	CDD:289560	15/68 (22%)
		ANK	872..>944	CDD:238125	15/72 (21%)
		ANK repeat	874..905	CDD:293786	3/30 (10%)
		ANK repeat	907..938	CDD:293786	10/31 (32%)
		BRCT	983..1063	CDD:214602	13/86 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900