DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank2 and C01G10.1

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_506722.2	Gene:	C01G10.1 / 180019	WormBaseID:	WBGene00007230	Length:	1213	Species:	Caenorhabditis elegans

Alignment Length:	828	Identity:	160/828 - (19%)
Similarity:	305/828 - (36%)	Gaps:	221/828 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1397 RVTSAYRTSMFSLSKHQNDHYIGDIRIVDL------------SNLLGKDWIQLAPEIGINGEEID 1449
            |||:|......::.|        :|::.||            :|::..|......|:...|||.:
Worm    37 RVTNAISLQAGAIRK--------NIKVRDLLVELIRMPRDQFNNIIDVDIKVARTELNRMGEEFE 93

  Fly  1450 E---IINQNTDSIARQAQSMIRLYKDKPNYDILSLETALKNIGRDDIMKKCKSGRLSHSREFDEA 1511
            :   ::..:|:|:.  ..:|..|   |.|...|||.:...:...|.|....|
Worm    94 KLSLLLQNDTNSLV--GDNMTDL---KNNLKFLSLFSQQTSTFLDAIKYPIK------------- 140

  Fly  1512 DLMKNSESV---EELVRRESKRIQQINEREEVKYSAEEKEVEESESDE--------EAAKRTVAE 1565
            :||.|..::   ..:.|....::...|.:.  .:.:...|:.|..:::        .|.|...::
Worm   141 NLMNNLTTIIANNSMFRSSCSQVDTDNFKS--FWDSINNELSEYATNDFPGFADTFVANKPNFSD 203

  Fly  1566 -------------------------RREKIVKRLSIERSIPASTQKKEIT--REITEIK-RKSLI 1602
                                     :.|.|::.::...::..|.:....|  |.::.:| .|||.
Worm   204 CLNYFPQLQAELDALPIWGGLEMIRKWEDIIRLVAKFDALSDSLRATNATLFRVLSSLKATKSLW 268

  Fly  1603 EDKKAHHESEILMQLPADNV-IIKTTTVPDQ-VIKMKMGKMDSTEVSKSEFDKELTHK-FKTSGR 1664
            :....::.::::.||..... |||....|.: |:|...|...|.:.||  ..|:|:.. |:   |
Worm   269 KSVHPNYHAQVMTQLNRSLFEIIKHHIAPTKPVLKYSAGFRSSRDFSK--ISKDLSSPWFR---R 328

  Fly  1665 SSEEEDQPSYPDQTDKIVQDISAAEKKEKDGVTFSRVTTI--TRQEARDITEDFLEIEKRSQLPA 1727
            :..:|.:....:...||..|||.|            ||::  :......:|.||...|.....|.
Worm   329 NIAKESKTKDLNHALKIFHDISEA------------VTSLDTSWHNFTALTLDFESSEVAKAGPI 381

  Fly  1728 TSTTATV------HEKFVEEIKEKTS-------------PLASVPQETVKEVQQVISEVTEIASK 1773
            ....:.:      :|..::....|.|             |.:|: ||.:::.||.||..|..
Worm   382 LDVISKMSLNFANYESIIQNASNKLSECFSNFSVTSLETPNSSL-QEMIQDFQQAISPATNY--- 442

  Fly  1774 KVENIISSFESSKSVDATTVLPTQPSVESTKVSETIKNLEDA--KAVSAEQVKTVHVVESSSIEE 1836
             ::.:....:....::..::|..:|       :.|||:..|.  |.:|.|       :|...:.:
Worm   443 -MKYLAQIRKQVSYININSILTIRP-------NRTIKSFFDEYYKKLSNE-------IEKQKVNK 492

  Fly  1837 T------------IAEFEAKKVKYDFHG-----GEPKTQIPKFTRK--PSDDSMKPTAAPRATVE 1882
            |            |.:.:.::|  |||.     .:....|...|.|  |:|     |...:..||
Worm   493 TNSLRVKTRLKIIIDQIDKREV--DFHNFMTHLSQNLKNIKVITNKSLPND-----TKIDKLLVE 550

  Fly  1883 SETESVLETKAEKPISKIPVKTIPTEAQKVSEVDARKITQDFLQGEKLAAEPKPSPAASKIPKVE 1947
                 :|:|...:.|||...:.. .:..:|.||....||.....|.|...  |.:....::.||:
Worm   551 -----MLDTSQLRGISKCLSQEF-MQPLRVLEVIEAMITVRQFAGNKTVL--KMNQYLDELAKVK 607

  Fly  1948 PRK-SVDKQ---VDRESKILDDVV--ASTATIMTAGLGD-----EQLKDQLVDHSEIIAKSETVA 2001
            .:. .|:||   :..:|....::|  ..|..:.||.||.     |.|::...:|
Worm   608 NQLWKVEKQIKLITSQSNSSHNLVLKLKTPELFTASLGTCAHVLEDLEEARQNH----------- 661

  Fly  2002 EKVTELLDTFHKIEEKVTKS----------EKTSEISSKVEELVKIEEKPLSQVQPKEDKVAEKV 2056
                :||..:.....:|.|:          :...::...::::..::.|  |::..|...::|.|
Worm   662 ----QLLSNYPDFPVQVLKTISGMGLREWLDPEQKLQVMLQKIDALDAK--SKMLRKNGNLSEMV 720

  Fly  2057 AEVIETFHKIEEKITTADARELTRDFLSMEQQNQLPSMPQAAEKPLES 2104
             :|.:...||..  ...|.::|.|.|..:::.::|..  |.|.|..||
Worm   721 -KVFDDASKING--IRGDPKDLYRLFRLLKKSSKLEK--QEAAKYFES 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786
		Ank_4	11..64	CDD:290365
		ANK	38..163	CDD:238125
		ANK repeat	43..74	CDD:293786
		Ank_2	48..135	CDD:289560
		ANK repeat	76..107	CDD:293786
		ANK repeat	109..134	CDD:293786
		Ank_4	110..163	CDD:290365
		Ank_4	172..225	CDD:290365
		ANK repeat	175..202	CDD:293786
		ANK	199..324	CDD:238125
		ANK repeat	204..235	CDD:293786
		Ank_2	209..300	CDD:289560
		ANK repeat	237..268	CDD:293786
		ANK	266..390	CDD:238125
		ANK repeat	270..300	CDD:293786
		ANK repeat	303..367	CDD:293786
		Ank_2	308..399	CDD:289560
		ANK	364..489	CDD:238125
		ANK repeat	369..400	CDD:293786
		ANK repeat	402..433	CDD:293786
		Ank_4	403..456	CDD:290365
		ANK repeat	435..466	CDD:293786
		Ank_2	440..530	CDD:289560
		ANK	463..588	CDD:238125
		ANK repeat	468..497	CDD:293786
		ANK repeat	501..530	CDD:293786
		Ank_2	506..597	CDD:289560
		ANK	529..654	CDD:238125
		ANK repeat	535..565	CDD:293786
		ANK repeat	567..598	CDD:293786
		Ank_2	572..661	CDD:289560
		ANK repeat	600..630	CDD:293786
		ANK repeat	633..662	CDD:293786
		ANK	661..785	CDD:238125
		ANK repeat	666..697	CDD:293786
		Ank_2	672..762	CDD:289560
		ANK repeat	699..730	CDD:293786
		ANK repeat	732..762	CDD:293786
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029	20/94 (21%)
		ER-remodelling	11936..>12013	CDD:258892
C01G10.1	NP_506722.2	WSN	23..91	CDD:197734	12/61 (20%)
		ANK	<872..944	CDD:238125
		ANK repeat	907..938	CDD:293786
		BRCT	991..1063	CDD:214602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900