Protein Alignment Ank2 and unc-44

DIOPT Version :9

• Sequence 1: NP_001189070.1
• Gene: Ank2 / 38863
• FlyBaseID: FBgn0261788
• Length: 13559
• Species: Drosophila melanogaster
• Sequence 2: NP_001367345.1
• Gene: unc-44 / 177366
• WormBaseID: WBGene00006780
• Length: 6994
• Species: Caenorhabditis elegans
• Alignment Length: 9466
• Identity: 2423/9466 - (25%)
• Similarity: 3653/9466 - (38%)
• Gaps: 3126/9466 - (33%)

  Fly     8 QGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDS 72
            :.:|:.|||||||||:||:|||.|:...|||||||||||:||||||:||..||.||::|.|.||:
 Worm    30 RAEGSASFLRAARAGDLEKVLELLRAGTDINTSNANGLNSLHLASKEGHSEVVRELIKRQAQVDA 94

  Fly    73 ATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQS 137
            ||:||||||||||||||..:|.:|:|:.|:|||||.||||||||||||||:.||:.||.:||||:
 Worm    95 ATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENHEEVVKYLLKHGANQA 159

  Fly   138 LATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTS 202
            |:|||||||||||:|||||:|||||||:|::||||||||||||||||..||||||.|:|||||||
 Worm   160 LSTEDGFTPLAVALQQGHDRVVAVLLENDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTS 224

  Fly   203 KSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAK 267
            ||||||||||:|||::|:..||::|||:|||.|:|||||||||.|||:|||.:|||.:|..|:::
 Worm   225 KSGFTPLHIAAHYGHENVGQLLLEKGANVNYQARHNISPLHVATKWGRTNMANLLLSRGAIIDSR 289

  Fly   268 TRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDE 332
            |:|.||||||||||||:||||:|:.:|||||||||||||||||||||:||||||.|||||||||:
 Worm   290 TKDLLTPLHCAARSGHDQVVDLLVVQGAPISAKTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDD 354

  Fly   333 VTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASIS 397
            |||||||.|||||||||||||||||||:||.|:|||||||||||||||||:|||||||::.|:|.
 Worm   355 VTVDYLTPLHVAAHCGHVRVAKLLLDRSADPNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIE 419

  Fly   398 ATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQV 462
            |||||||||||||||||.:||||||||..|:|||.||||||||||||||||||::|:|:||||:|
 Worm   420 ATTESGLTPLHVAAFMGAINIVIYLLQQGANPDVETVRGETPLHLAARANQTDVVRVLIRNGAKV 484

  Fly   463 DARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAA 527
            ||:|||.||||||||||||.|||:||||.||..:|||:|.|:.|||||||||:|||.:|:::.|.
 Worm   485 DAQARELQTPLHIASRLGNTDIVILLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNAD 549

  Fly   528 LDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGA 592
            ....||||||||||.:|||:::|.:|||::...||.:|||.|||||||.||||.:||:||||.||
 Worm   550 KTLLTKKGFTPLHLASKYGNLEVVRLLLERGTPVDIEGKNQVTPLHVAAHYNNDKVAMLLLENGA 614

  Fly   593 SPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHK 657
            |..|.||||:|||||||:||||:||:|||::.|..||:|:|||||||||:||||.|||.||||:.
 Worm   615 SAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIENG 679

  Fly   658 AAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQN 722
            :.|...|.||||.||||||||:|.||:||..|||.|:..|.|||||||||.||||.|||:||::|
 Worm   680 SDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVEN 744

  Fly   723 GANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSLKT 787
            ||:|...|...||||||.|||||.:.|..|||:.|:.|.||..|||||.||::|||:||:::|:|
 Worm   745 GADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGYVSVVETLRT 809

  Fly   788 ITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGG--------------EDNM---LSDQP 835
            :| |.......:..:|:|:...||||:|:..|:||:||.              .||:   |.|.
 Worm   810 VT-ETTVITETTTVDERYKPQNPEAMNETMFSESEDEGQAAEHEAVAAHEKDFSDNLTQGLQDS- 872

  Fly   836 YRYLTVDEMKSLGDDSLPIDVTRDE-----RMDSNRMTQSAEYASGVPPTIGEEVISPHKTQVYG 895
                |...|...|:..|......:.     :::|..|:...|:|. :.|......|:...:|.:|
 Worm   873 ----TGVHMIHTGEQLLQRSQELENGGAIPKINSGGMSPEKEFAK-IAPVATSSPIATSNSQSFG 932

  Fly   896 SSPKA-TVDGVY------------------------------IANG------SGH-DEPP---HV 919
            .:|:| ::.|.:                              ..||      :|| |..|   ||
 Worm   933 IAPRAGSISGQFQQQPLHGAGPEDNLEELVRRAQNHPINAGNYDNGGVAMLENGHADNVPIGHHV 997

  Fly   920 GR--KLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPSRSTCQPTRVTCRYVKPQRTMHPPQLME 982
            .:  ||..::||:||||||||||||||||||||:|:|.|...||.||||||::..:..|||.|.|
 Worm   998 TQPSKLQHRTFLISFLVDARGGAMRGCRHSGVRIIVPPRKASQPIRVTCRYLRKDKLAHPPPLSE 1062

  Fly   983 GEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKEREIIILRSDNGETWREHTIDNSEEIIHDV 1047
            ||.||||:||:.|...||:|||::|||||||||.:||||:|||||:|:.|:||.::.:|:.:.:|
 Worm  1063 GEELASRILEMAPAGAKFLGPVILEVPHFASLRDREREIVILRSDDGQHWKEHQLEATEDAVQEV 1127

  Fly  1048 LQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSRIRQEVHAIGPEGGMVSSTVVPQVQAVF 1112
            |.:.|:.|::|||::.....:.|.:|.|||.|||||:|:|||||.:|||||::.|:|||:|||:|
 Worm  1128 LNESFDAEDLAQLDDLQTPRITRILTSDFPMYFAVVTRVRQEVHCVGPEGGVIISSVVPRVQAIF 1192

  Fly  1113 PQGALTKKIKVGLQAQPVDPDLTAKLLGRGVAVSPIVTVEPRRRKFHKAITLSMPAPKAHSQGMI 1177
            |.|:|||.|||.:|||||..::..:|.|..||||||||||||||||||.|||.:|.|:::::||:
 Worm  1193 PDGSLTKTIKVSVQAQPVPQEMVTRLHGNRVAVSPIVTVEPRRRKFHKPITLCIPLPQSNNRGML 1257

  Fly  1178 NQYSG----NTPTLRLLCSITGGPSRAQWEDVTGSTPLTFVNDCVSFTTTVSARFWLMDCRNISD 1238
            .||||    ..||||||||||||.:.|||||:||:|.|||..|.||||||||||||||||:...|
 Worm  1258 TQYSGQQGQEPPTLRLLCSITGGSAPAQWEDITGTTQLTFTGDEVSFTTTVSARFWLMDCQTPRD 1322

  Fly  1239 ATKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKLRVFCMTDDREDKTLEKHELYTEVAKSRDVE 1303
            |.:||.|:|.|.|.:|::|||.|||::..|.|.:|||||||||:|||||||.|.:..:|||||||
 Worm  1323 AARMAQEVYNEAISIPYMAKFAVFARRTFPVEGQLRVFCMTDDKEDKTLEKQEHFKLIAKSRDVE 1387

  Fly  1304 VLEGKPQYIEMAGNLVPVTKSGDQLQVQFKAFRENRLPFTVRVK---DQHADIVGRTLFMKEPKV 1365
            ||:||.|::|.:|||||:|||||||.:.|..|:||||.|.|:.:   |..|...||..||.|||:
 Worm  1388 VLKGKHQFLEFSGNLVPITKSGDQLSLFFLPFQENRLAFMVKTRSNDDNEAATEGRIGFMAEPKI 1452

  Fly  1366 -AKGEPPQQPICILNIVLPEAVIPDST--------TAFSDRVTSAYRTSMFSLSKHQNDHYIGDI 1421
             :...|||||||.|.|.|||......|        |.|..|..||....:... .|||
 Worm  1453 RSDALPPQQPICTLAISLPEYTGEIKTAPPPKKDLTPFEQRYGSALEKDLPEF-VHQN------- 1509

  Fly  1422 RIVDLSNLLGKDWIQLAPEIGINGEEIDEIINQN--TDSIARQAQSMIRLYKDKPNYDILSLETA 1484
                :...:|.||.:|...:.:...:|.. |.||  ........:..|.|.|:..|.|  :|:.|
 Worm  1510 ----VLKGIGADWPRLGRALEVPHRDIQH-IRQNYPGQECKNTLKIWIHLKKEDANQD--NLDQA 1567

  Fly  1485 LKNIGRDDIMKKCKSGRLSHSREFDEADLMKNSESVEELVRRESKRIQQINEREEVKYSAEEKEV 1549
            |:.||||||::                                           .:.|...:..:
 Worm  1568 LRQIGRDDIVR-------------------------------------------SIAYGEPDALI 1589

  Fly  1550 EESESDEEAAKRTVAERREKIVKRLSIERSIPASTQKKEITREITEIKRKSLIEDKKAHH--ESE 1612
            ..|::|..:.||......|:          :||:|..|...|....:.|:.:   :..||  ::.
 Worm  1590 NYSQADSPSQKREPIRHFEE----------VPAATLVKREVRTEDLVTREPV---QPTHHVEQAT 1641

  Fly  1613 ILMQLPADNVIIKTTTVPDQVIKMKMGKMDSTEVSKSEFDKELTHKFKTSGRSSEEEDQPSYPDQ 1677
            .::|.|:.:..:..:.||::
 Worm  1642 TVVQEPSYSAPVHHSPVPEE--------------------------------------------- 1661

  Fly  1678 TDKIVQDISAAEKKEKDGVTFSRVTTITRQEARDITEDFLEIEKRSQLPATSTTATVHEKFV--- 1739
                      .|.:|:..|...|....|.:...| :||...:|:|       |..|.:|..|
 Worm  1662 ----------PEMEEEAPVAEMRTVVRTERHVHD-SEDGPVVEER-------TITTTYEDDVAVN 1708

  Fly  1740 EEIKEKTSPLASVPQETVKEVQQVISEVTEIASKKVENIISSFESSKSVDATTVLPTQPSVESTK 1804
            |.|.::|.||.       ::.||...|:..:|.          |||.|          |:..||.
 Worm  1709 ENIVDRTVPLN-------EDEQQKWEELNRLAD----------ESSPS----------PAQRSTI 1746

  Fly  1805 VSETIKNLEDAKAVSAEQVKTVHVVESSSIEETIAEFEAKKVKYDFHGGEPKTQIPKFTRKPSDD 1869
            |:|:          ::|||                                          |.|
 Worm  1747 VAES----------TSEQV------------------------------------------PED- 1758

  Fly  1870 SMKPTAAPRATVESETESVLETKAEKPISKIPVKTIPTEAQKVSEVDARKITQDFLQGEKLAAEP 1934
                       ||...||  |:..|.. ..|...|:.|  ..:||                  .|
 Worm  1759 -----------VEQSVES--ESHREDD-GTIVTTTVTT--SHISE------------------SP 1789

  Fly  1935 KPSPAASKIPKVEPRKSVDKQVDRESKILDDVVASTATIMTAGLGDEQLKDQLVDHSEIIAKSET 1999
            ..||.         |:||:.:..|.|: .:|..||         |.||...|         .|.|
 Worm  1790 SGSPT---------RRSVEPEEHRHSQ-HEDHEAS---------GAEQHSGQ---------DSGT 1826

  Fly  2000 VAEKVTELLDTFHKIEEKVTKSEKTSEISSKVEELVKIEEKPLSQVQPKEDKVAEKVAEVIETFH 2064
            ..:|.|        .||..|..:.:..:|.|:..:|......|    |.|.:........:|:..
 Worm  1827 TQKKET--------AEEGFTNEDGSVVVSKKMTRVVTTTRTTL----PGEGEEPSAPDSPVESLG 1879

  Fly  2065 KIEEKITTADARELTRDFLSMEQQNQLPSMPQAAEKP-----LESSLTSTSASEPESIVTVKPSP 2124
            .::::|.            ..||...||..|..:..|     |:|......:...||...|:...
 Worm  1880 SVKDRIA------------KFEQFKTLPIDPSVSGPPPSAHTLQSEEYQEESGNVESAYDVETDR 1932

  Fly  2125 PASKIPVVEPRKIVFDESTKPLIEPEPVKTTEKKPLNERQLTADFLSMEQQTQLVSEPAKSLVEE 2189
            ..|:..:...|.|       |.|...|         :|.|.:..|.|.|.......:..:||
 Worm  1933 RDSERSLKSERSI-------PEIHTSP---------SEEQQSEHFESAEHTEDQGRDSGRSL--- 1978

  Fly  2190 VMKSAEQMVEQPKQQKSLNERQLTEDFLLMEQQTQLPSDIVKPTDKLIDGIESAAPVGDEASPFH 2254
                        |..:|:.|.|.||....:|:........::||            ||...:| |
 Worm  1979 ------------KSDRSIPEVQFTESDSELEKHDLHEDSHLEPT------------VGIVITP-H 2018

  Fly  2255 TPKLTTSVVTQEPQQLASEYDSDTFGKQATIPLGDSKIDQGLIAPVSMEPRKSLTDAEFCKSVGE 2319
            ||     |..:.|..     ..|...:|...||..|:.:.  :|...::..:..:|        |
 Worm  2019 TP-----VPPEHPDD-----KEDIEDEQPQEPLEPSEPEH--VAHAELKDTREYSD--------E 2063

  Fly  2320 TITKKMSVGVIEISD-ELKKIESEIPHS----------QTPPPTPSDNKTDKQNEEPELISLERD 2373
            .:.:::|.....:|. |:|.|:|..|.|          :..||.|........:...|::|...|
 Worm  2064 ELAQELSPSEEHVSTAEIKDIKSYSPTSSDDERSSQKGKVSPPIPQVRHAISPSVASEVLSSHDD 2128

  Fly  2374 YLADTVTTLHTTTESTLERVSAITKIEHFSVHNVKSETFTRTDEPDKLLHSVVAPPDIQKLYSQD 2438
            .||                       .||     .:|:|.:.||.:
 Worm  2129 ELA-----------------------AHF-----VAESFEKHDEGN------------------- 2146

  Fly  2439 TTSFTEMSTSSQTPKMTTTTTMTAQIDRTKVDLTIPGQDQQKQKDLKEQSAVVVDAKAETEKTAS 2503
                  :.|..|||......:              |||                     |....|
 Worm  2147 ------VETIEQTPVYKGHHS--------------PGQ---------------------TSPIVS 2170

  Fly  2504 DREYLEQIMGCGDVRRKIMRLESSCSTESLESVGKSSTVTPKYIGDNVPVVREVVQSMEDKICST 2568
            :..:.::.                           :.:||....|||:    .:....|.:|...
 Worm  2171 EHPHAQEY---------------------------AESVTSHDEGDNL----SLKSGHEPEIARH 2204

  Fly  2569 VVSAIPFTVQKRKPHDDDKEPNIVELEKQILTPADLALEKIFKCEPPSEVVKISPIEAMSLGLK- 2632
            .|:::     :.:..|||::..:.:..|:    |.:.:..:.          .:|:...::|.|
 Worm  2205 SVASV-----QEEDDDDDEKSELGDFAKK----AGMIVGGVI----------AAPVALAAVGAKA 2250

  Fly  2633 -------EIDEEVCEKVCEKRKSFVVAEDLCETEKTLTEQVIDLNRQVDQVPARVFTETIERHLD 2690
                   :.|||..|...||        ::..|:.|:.|..|                   ||.|
 Worm  2251 AYDALNRDDDEEKLEGHEEK--------EVLTTQTTIMESPI-------------------RHED 2288

  Fly  2691 LEDRDVIEALPK----------VREVVQDIERKY---PAASLEAKPFSPRKRVTPDRKVDVSSLE 2742
            :....:.:..||          |.|....:.|.|   |....||.| :|...|..:|.:.
 Worm  2289 IPSPHLEDVTPKVSHQEHPYEHVTETTTTVTRDYYEQPEDHREASP-APSSHVESERPIS----- 2347

  Fly  2743 QQILTDADLILDGLGSKCVPEQKVQSPIFSSNKASS-STENLEDICEKKCSKRTISDMTKVFERQ 2806
                                    :||..|..:.|. :||             |.:.:|:.::::
 Worm  2348 ------------------------ESPAVSEREPSHIATE-------------TTTTVTREYDQE 2375

  Fly  2807 ---EDPTTMPSIKDVKSTTAKFLESESGKFAITESIQHFNAKGSINKEVAGIEKGQIRFLKDCDT 2868
               :..:...|::|:                ::|..:|                      ..||:
 Worm  2376 PKADQSSARESVRDL----------------VSEEHEH----------------------PACDS 2402

  Fly  2869 QEF--------PIETNLDTKLVEFPKITHTLERLHSISKTDIADTKKVVHESSEFKSKLDKLVHK 2925
            :..        |:||                                  |..|:|.:    ||..
 Worm  2403 ERLSEPAQSPEPVET----------------------------------HAESQFSN----LVET 2429

  Fly  2926 TEQTDNQNPDKFKFPTQDNFDELQTQKSLTSELVTMTDSSEYKFPPEGKSILGKEPIESESDEEL 2990
            |..|         ..|::.:||.|                             :|...|.:.:|
 Worm  2430 TTTT---------AVTREFYDEDQ-----------------------------EEQASSRATKE- 2455

  Fly  2991 DNLNKICKLQLLSKIEQSSFIDTTEIANTEKREITKFPTTNDSHSDLFSKSRATLKTQSGEKTHC 3055
                         :||||.......|.:||.|:                     ..||..|::
 Worm  2456 -------------RIEQSPVASERSIVSTEHRQ---------------------SPTQESEQS-- 2484

  Fly  3056 THFTETISDKNYNSFSDTSFLLNSVTASADKSPLHPEEKTKSPEKKDEKVLAQPDDNFKSVIETD 3120
               .|..|:||.::.::|:    :||....:.|:..|.:..|.|      ..|..::|:..:
 Worm  2485 ---LEPTSEKNVHTVTETT----TVTRECFEEPIASELEHASRE------FEQGSNDFRRSV--- 2533

  Fly  3121 KPSPKEYSDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKPKSPVKIDEEVLAKPGGSSK 3185
              ||.:..:::::|.. ..|.||..|          :.|:     |:||               .
 Worm  2534 --SPVDAQEQVDVPHS-PAPSSHAES----------EQPV-----PESP---------------H 2565

  Fly  3186 SVVETDKPS--PKEYSDDETEDEIDFPKPQDKPFKEATPSVTPVSTIPDVKAIDFVSFKAEECST 3248
            .:|||...:  .:|:.|:|      :|:|:........||....|..|.:
 Worm  2566 HIVETTTTTTVTREFQDEE------YPRPESPAEIFPIPSSEQQSEEPHI--------------- 2609

  Fly  3249 TIQTNIKLASTSLTTKDTKIVQPIDSLSNLKDDKFPTSVGDKAKSPRESVKPNLKEYSDKEEKPD 3313
                   :..|:.||..|:.:.......|:.....|:|..:..:...||...:.:||      |.
 Worm  2610 -------VKETTTTTTVTRELYDEPEKGNVTFSPAPSSHAESERQVPESPVVSHQEY------PH 2661

  Fly  3314 SHPVSLVTSVTGSGDKSPLHPEEK--PKSPEKKDEKILAKPDDSSKSVVKTDKPSPKEYSDDEIE 3376
            ....:..|:||     |.::.:|.  |.|.:...:..     ..|::.|....|...|.||.|
 Worm  2662 VVETTTTTNVT-----SNIYDDEDNVPSSEDPATQHF-----QQSETSVHRSHPDSVEESDGE-- 2714

  Fly  3377 DEIEIPKPLDKPISHPTSLVTSVTGSGDKSPLHPEEKPKSP---------------EKKDEKVLA 3426
                             .|.:.|.|...|:.:.......:|               ||.||
 Worm  2715 -----------------GLGSKVLGFAKKAGMVAGGVVAAPVALAAVGAKAAYDAFEKDDE---- 2758

  Fly  3427 KPDDSSKSVVKTDKPSP----KEYSDD-----ETEDEIEIPKPLDKPISHPTSLVTGVTFGGDKS 3482
             .|::|.|   .:.|.|    ::|.||     .|:.|..:|   :.||.|...     |...|.|
 Worm  2759 -DDETSHS---PESPVPEYQSEQYQDDSAQSSHTDFEHHMP---ESPIEHEKE-----TEEFDHS 2811

  Fly  3483 PLHPEEKLKSPEKKDEKVLAKPDDSSKSVVKTDKPSPKEYSDDETEDEIEIPKP-LDKPISH--- 3543
              |||..:.|.::::.:|        .|...|.....:|| :||.|||.|...| ...|.||
 Worm  2812 --HPESPVLSEKEREHQV--------TSETTTTTTVTREY-NDEPEDEQEHQGPHSPAPSSHTEA 2865

  Fly  3544 ------PTSLVTGVTFGGDKSPLHPEEKLKSPEKKDEKVLAKPDDSSKSVVKTDKPSPKEYSDDE 3602
                  .|:..|.||          .|..:.||:.:.|   :.|:|.|        ||..:|.:.
 Worm  2866 EHPHIVETTTTTTVT----------REFQEEPEELEYK---QEDNSRK--------SPSSHSQEN 2909

  Fly  3603 TEDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKPKSPEKKDEKVLAKPDGSSKSVVKTD 3667
            ...|              |:..|.||......|.|.||:                       :|.
 Worm  2910 LVTE--------------TTTTTTVTSEYYDEPEHFEEQ-----------------------ETG 2937

  Fly  3668 KPSPKEYSDDETEDEIEIPKPLDKPI-SHP-----TSLVTGVTFGGDGSPLHREEKPKSPEKKDE 3726
            |.||...|..|:|.::     |:.|: |.|     |:..|.||     ...|.:|..:|.....:
 Worm  2938 KSSPAPSSHVESERQV-----LESPVASDPRHVMETTTTTTVT-----RQFHDDESERSDSPNRD 2992

  Fly  3727 KVLAKPDDSSKSVVKTDKPSPKEYSDDETEDEIEIPKPL---DKPISHPTSLVTGVTYGGDGSPL 3788
            .|      .::|:..::..|.:::|:.: :|....|.|:   |:|:.|
 Worm  2993 VV------EAQSIHSSNIESHQQFSEKD-DDSQRGPSPVKSEDEPVKH----------------- 3033

  Fly  3789 HPEEKPKSPEKKDEKVLAKSDDSSKSVVKTDKPSPKEYSDDETEDEIEIPKPLDKPISHPTSLVT 3853
                                 :|.|  .:|.....:|:...|.:.| .:.:|...|:
 Worm  3034 ---------------------ESYK--FETSTTETREFDRPELDSE-RLSEPAQSPM-------- 3066

  Fly  3854 GVTFGGDGSPLHPEE---KPKSPEKKDEKVLAKPDGSSKSVVETDKPS--PKEYSDDETEDEIEI 3913
                  :.||:..||   :|.|..|.:    ...:|...||:||...:  .:|:.||: :||.|
 Worm  3067 ------EVSPITTEENIVRPSSSVKSE----YGSEGHVPSVIETKTTTTVTREFYDDD-QDEHE- 3119

  Fly  3914 PKPLDKPISHPTSLVTGVTFGGDGSPLHPEEK----PKSPEKKDEKVLAKPDDSSKSVVKTDKPS 3974
                                    :....||.    |...|:.:...|.|...::.:|.:
 Worm  3120 ------------------------NQTQSEELRSSIPTEEEEHEGSHLFKETTTTTTVTR----- 3155

  Fly  3975 PKEYSDDETEDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKLKSPEKKDEKVLAKPDDS 4039
             :.|.:.|..:|::.|:....|.||.            :|.:|..|   ||..:.:::
 Worm  3156 -EFYDEPENVEELQDPQFSPAPSSHV------------ESGIHASE---SPVAQQQEI------- 3197

  Fly  4040 SKSVVKTDKPSPKEYSDDET------EDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEE-- 4096
                     |..:|:.:|..      |:|.|         ||..:         :::||..|:
 Worm  3198 ---------PQTREFHEDSPAAQYFHEEEYE---------SHVLT---------EQAPLLTEQQH 3235

  Fly  4097 KPKSPEKKD-----EKVL--AKPDG----------------SSKSVVETDKPSPKEYSDDETEDE 4138
            :|:|.::.|     .|||  ||..|                .:|:..:..|....|...:|.|..
 Worm  3236 QPESGDESDGEGLGSKVLGFAKKAGMVAGGVVAAPVALAAVGAKAAYDALKKDDDEEDQEERESL 3300

  Fly  4139 IEIPKPLDKPISHPTSLVTGVTFGGDGSPLHPEEKPKSPEKKDEKVLAKPDDSSKSVV---KTDK 4200
            :...:.:|.|                    |..|:.:. |::.|:....|..|.|..|   .|..
 Worm  3301 LRQERSIDSP--------------------HASEQSQI-EEEHERFEESPVPSEKHHVTETTTTT 3344

  Fly  4201 PSPKEYSDD-------ETEDEIEIPKPLDKPISH--PTSLVTGVTFGGDGSPLHPEEKPKSPEKK 4256
            ...:||.|:       |.|.|...|...:|.:.|  .|:..|.||...|   .:..|.|...||:
 Worm  3345 TVTREYFDEHEPLVSQEIEGEKGSPADSEKSLPHVVETTTTTTVTREFD---KNDSESPVPSEKE 3406

  Fly  4257 DEKVLAKPDDSSKSVVKTDKPSPKEYSDDETEDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLH 4321
            .|     |...|:.|.:|.:....|:...||.......:.:|                 |...:.
 Worm  3407 QE-----PTTVSREVYETAEGDEPEHHYTETTTTTVTKEVID-----------------DSQEMG 3449

  Fly  4322 PEEKPKSPEKKDEKVLAKPDGSSKSVVETDKP--SPKEY--SDDETEDEIEIPKPLDKPISHPTS 4382
            .:::||.              .|..||||...  :.:||  :||||..|..     |..|:..|.
 Worm  3450 DDDEPKQ--------------ESPQVVETTTTTMTSREYDDNDDETRSEAG-----DSHITETTK 3495

  Fly  4383 LVTGV-TFGGDGSPLHPEEKPKSPEKKDEKVLAKPGGSSKSVVETDKPSPKEYSDDETEDEIEIP 4446
            ..|.| .|.|        |:|:..|:.||.....|     .:.|.|..|  |||:..|....|:
 Worm  3496 TTTVVREFHG--------EQPEETEETDEVEELPP-----KIEEEDNVS--EYSESSTSVSREV- 3544

  Fly  4447 KPLDKPISHPTSLVTGVTFGVDKSPLHPEEKPNSPEKK-DEKVLAKPDDSSKSVVKTDKPIPKEY 4510
            :| |:|....|:..|.||          .|..|.||:. |::..|.|...|           :|:
 Worm  3545 RP-DEPHIIETTTTTTVT----------REYHNEPEETYDDQKDAAPISFS-----------QEH 3587

  Fly  4511 SDDET-----EDEIEIPKPLDKPISHPTSLVTGVT-----FGGDGSPLHPEEKPKSPEKKDEKVL 4565
            .||::     :.:.|.|...:|.:.|.|...|..|     :..:.|.:. .|.|.:.|:.:....
 Worm  3588 QDDDSQASHDQHDRESPVESEKSVKHTTETTTTTTVTRQLYDDEASEIR-GESPVATEEHEHVSS 3651

  Fly  4566 AKPDDSSK----SVVKTDKPS--PKEYSDDETEDEIE-----------IP----KPLDKPISHPT 4609
            .|.||.|:    ||::|...:  .:|:.||:.|.:.|           ||    :..|..:...|
 Worm  3652 TKSDDESEQHVPSVIETTTTTTVTREFYDDQDELQREDHTQSEERRSSIPTEETEHEDSHLIKET 3716

  Fly  4610 SLVTGVTFGGDGSPLHPEE--------KPKSPEKKDEKVLAKPDGSSKSVVET-----DKPSPKE 4661
            :..|.||......|.:.|:        .|.|..:.:..|...|....:.:.:|     |.|:.:.
 Worm  3717 TTTTTVTREFYDEPENVEKLQDSQFSLSPSSHVESEIYVPESPVAKQQEIPQTREFHEDSPAAQY 3781

  Fly  4662 YSDDETEDEIEIPKPLDKPISHPTSLVTGVTFGGDGSPLHPEE--KPKSPEKKD-----EKVL-- 4717
            :.:||.|.::            ||          :.:||..|:  :|:|.|:.|     .|||
 Worm  3782 FHEDEYEHQV------------PT----------EQAPLLTEQQHQPESGEESDGEGFGSKVLGF 3824

  Fly  4718 AKPDG----------------SSKSVVETDKPSPKEYSDDETEDEIEIPKPLDKPISHPTSLVTG 4766
            ||..|                .:|:..:..|....|...:|.|..|...:..|.|.:...|.:
 Worm  3825 AKKAGMVAGGVVAAPVALAAVGAKAAYDALKKEDDEEDQEERESLIREERSFDSPHASEQSQI-- 3887

  Fly  4767 VTFGGDGSPLHPEEKPKSPEKKDEKVLAKPGGSSKSVVETDKPS---PKEY---SDDETEDE--- 4822
                 :......||.|...||..::..|.|..|....:|.:..:   ..|:   ||..|||:
 Worm  3888 -----EKEHKRFEESPVPSEKHHDQSSALPQESVSQPIEKESRTFNDESEFGVKSDHYTEDDQES 3947

  Fly  4823 IDFPKPQDKPFKEATPSVTPVSTIPDVKAIDFVSFKAEECSTTIQTNIKLASTSLTTKDTKIVQP 4887
            :..||...:.|.:                  |.|.|.::.|                 |:.|...
 Worm  3948 LKSPKESGEAFSQ------------------FTSEKEQDRS-----------------DSPIHSQ 3977

  Fly  4888 IDSLSNLKDDKFPTSVGDKAKSPRESVKPNLKEYSDKEEKPDSH-----PVSLVTSVTGSGDKSP 4947
            .:.:|..:::..|..|  |::.|.:..||:|       |:..|:     |.|...|:||..::..
 Worm  3978 KEDISQFQNESSPEDV--KSEQPHDEEKPDL-------ERQGSYSSGYSPKSPGGSITGLDEEKA 4033

  Fly  4948 L----HPEEKPKSPEKKDEKVLAKPDDSSKSVVETDK--PSPKEYSDDETDDEIEIPKPLDKPIS 5006
            |    .||::|::..:..||..|..|:   ::.|:||  |:....|:|.::..||
 Worm  4034 LSGVQEPEDRPENFAESHEKTEATSDE---NLFESDKYAPASPVPSEDSSNRVIE---------- 4085

  Fly  5007 HPTSLVTGVTFGGDKSPLHPEEKPKLPEKKDEKVLAKPDDSSKSVVKTDKPIPKEYSDDETDDEI 5071
              |:..|.||    :....||:        |...:.:..:.|.|    ..|:|.|
 Worm  4086 --TTTTTTVT----REHFEPED--------DHSYVVESQEYSSS----GSPVPSE---------- 4122

  Fly  5072 DFPKPLDKPI-SHPTSLVTGVTFGVDKSPLHPEEKPKLPEKKDEKVLAKPDDSSKSV------VK 5129
               |.:|:.| :..|:.||...|..:      :|.|.:.|...:...|.|..|.:.|      ..
 Worm  4123 ---KSVDRVIETTTTTTVTREHFEAE------DEIPTIVESSHDDQAASPVPSEEDVHEQIQTTT 4178

  Fly  5130 TDKPIPKEY--SDDETDDE---------IEIPKPLDKPISHPTSLVTGVTFGVDKSPLHPEEKPN 5183
            |...:.||:  .|||.|.|         ...|.|.::..|..|...|..|  |.:....||
 Worm  4179 TTTTVTKEHFVPDDEIDSEHMNESDKYASGSPVPSEEDSSRVTETTTTTT--VTREHFEPE---- 4237

  Fly  5184 SPEKKDEKVLAKPDDSSKSVVKTDKPIPKEYSDDETDDEIEIPKPLDKPISHPTSLVTGVTFGGD 5248
                         ||.| .||:|     :|||..|:      |.|.:|.:.......|..|...:
 Worm  4238 -------------DDHS-PVVQT-----QEYSASES------PVPSEKSVERVIETTTTTTVTRE 4277

  Fly  5249 GSPLHPEEKPKSPEKKDEKVLAKPDDS--SKSVVKTDKPSPKEYSDDETEDEIEIPKPLDKPISH 5311
                |.|::.....::.|.....|.:|  |:::.:....||.:.:.||     |...|...|...
 Worm  4278 ----HFEDEDHILGQQGESDSQIPSESITSENMDRETSSSPVQSNRDE-----EFVLPAIAPYKQ 4333

  Fly  5312 PTSLVTGVTFGGDGSPLHPEEKPKSPEKKDEKVLA---KPDDSSKSVVKTDKPSPKEYSDDETED 5373
            ||......:.....||....|.|....|::|...|   :......||...|.|:.:.:.|:|::.
 Worm  4334 PTEYGRVDSHDAPASPAPSAESPIQAYKQEESQEAHSLEQFQQRSSVSHEDSPAAQYFHDNESDH 4398

  Fly  5374 EIEIPK---PL-----DKPISHPTSLVTGVTFG-------------GDGSPLHPEEKPKSPVKIE 5417
            :..:|.   ||     .:|.|...|  .|..||             ..|....|........|..
 Worm  4399 DSPVPSDRAPLLTEQQHQPESGEES--DGEGFGSKVLGFAKKAGMVAGGVVAAPVALAAVGAKAA 4461

  Fly  5418 EEVLAKPDDSSKSVVETDKLSPK-----------EYSDDE-TEDEIEI--PKPLDKPFKEAMPSV 5468
            .:.|.|.||..::..|.:||.||           |.||.| :|.|:|.  |.|.:|
 Worm  4462 YDALKKDDDEDENPDEQEKLLPKSPERQVLVNPVEPSDSEISEIELEYTSPSPTEK--------- 4517

  Fly  5469 TPVSTIPDVRAIDVVSFKAEECST-TIQTNIKLASTSITTKDTKIVKPIDSLSNLKDDKFPTSVG 5532
                             ...:|.| |::|      |::|.:             ..||  |.||
 Worm  4518 -----------------SESQCYTETVRT------TTVTRE-------------YLDD--PQSV- 4543

  Fly  5533 DKAQSPRESVKPNLKEYSDKEEKPDSHPVSLVTSVMGSGDKSPLHPEEKPKSPEKKDEKVLAKPD 5597
            .:::||.|                  |.:|               .:..|:||.::|..|:.|
 Worm  4544 TRSRSPSE------------------HDIS---------------EQYAPESPVEQDPYVVEK-- 4573

  Fly  5598 DSSKSVVKT--DKPSPKEYSDDETDDEIDFPKPL------DKPISH--PTSLVTGVTFGVDKSPL 5652
              :.:|::.  |:| |:|..:....:|:...:.:      |:|..|  .|...|.:|
 Worm  4574 --TTTVIRQYHDEP-PQEIEEQTIPEEVTVLREVYESPEGDEPEQHYIETKTTTTIT-------- 4627

  Fly  5653 HPEEKPKLPEKKDEKVLAKPDDSSKSVVKTDKPIPKEYSDDETDDEIDFPKPLDKPISHPTSLVT 5717
               ::..:|.::|.::  .|..|..||  ::|.:|   :|::          ||:|::..|:..|
 Worm  4628 ---KEVHVPVEEDVQI--SPVHSETSV--SEKQLP---ADEQ----------LDEPVTESTTTAT 4672

  Fly  5718 GVTFGMDKSPLHPEEKPNSPEKKDEKILAKPDDSSKWVVKTDKPIPKEYSDDETDDEIEIPKPLD 5782
             ||          .|:...||:      .:|...|                 |.|||...||.::
 Worm  4673 -VT----------RERYEEPEE------VRPPSGS-----------------EADDESHAPKYME 4703

  Fly  5783 KPISHPTSLVTSVTGSGDKSSLHPEEKPKSPEKKDEKVLPKPDDSSKSVVK-------------- 5833
                  |:..|:||...:.|. ..:|..:|..::||...|. :||.|.|::
 Worm  4704 ------TTTTTTVTREYEVSE-DEDEHQQSQVQRDESPAPS-EDSVKHVIEKTTTTTVTEERYEP 4760

  Fly  5834 --TDKPIPKEYSDDETDDEIDFPKPLDKPISHPTSLVTGVTFGMDKSPLHPEEKPNSPEKKDEKV 5896
              :..|:|.|      ||...|.|        .|:..|.||        |...:|..| ..||.|
 Worm  4761 EDSHSPVPSE------DDVHGFVK--------TTTTTTTVT--------HEHFEPEDP-PSDEHV 4802

  Fly  5897 LAKPDDSSKWVVKTDKPIPKEYSDDETDDEIEIPKPLDKPISHPTSLVTGVTFGMDKSPLHPEEK 5961
            :    :|.::.  :..|:|   |::::..|||         :..|:.||...|.:
 Worm  4803 V----ESERYA--SGSPVP---SEEDSSREIE---------TTTTTTVTREHFEL---------- 4839

  Fly  5962 PNSPEKKDEKVLAKPDDSSKWVVKTDKPIPKEYSDDETEDEIEIPKPLDKPISHPTSLVTSVTGS 6026
                           :|..:.||::     :|||...:      |.|.:|.:.......|:.|.:
 Worm  4840 ---------------EDDQEHVVES-----QEYSASGS------PVPSEKSVERVIETTTTNTVT 4878

  Fly  6027 GDKSSLHPEEKPKSPVKTEEKVLAKPDDISKSVVETDKPSPKEYSDDETEDEIEIPKPLDKPISH 6091
            .:    |.|.:               ||| .::|||....|...|....||            .|
 Worm  4879 RE----HFEHE---------------DDI-PTIVETSHDDPAASSVPSEED------------VH 4911

  Fly  6092 PTSLVTGVTFGVDKSPLNPEEKPNSPEKKDEKVLAKPDDISKSVVKTDKPIPKEYSDD---ETDD 6153
            .....|..|..|.:..:.|:|:.:|         .:.|::.|  ..::.|:|.|....   ||..
 Worm  4912 GQIQTTTTTTTVTREHVVPDEEIDS---------GRMDELEK--YSSESPVPSEEDSSRVIETTT 4965

  Fly  6154 EIEIPKPLDKPISQPTSLVTGATFGGDGSPLHPEEKPKSPEKKDEKVLAKPDGSSKSVVETDKPS 6218
            ...:.:...:|....:.:|....:...|||: |.||                 |.:.|:||...:
 Worm  4966 TTTVSREHFEPEDDHSHVVESQEYSASGSPV-PSEK-----------------SVERVIETTTTT 5012

  Fly  6219 --PKEYSDDETEDEIEIPKPLDKPISHPTSLVTGVTFGMDKSPLHPEEKPNSPEKKDEKVLAKPD 6281
              .:|:.|.| ||.|    |.:...||.    .|:|                    |:.|   |.
 Worm  5013 TVTREHFDTE-EDYI----PSESRTSHD----DGIT--------------------DQHV---PS 5045

  Fly  6282 DSSKWVVKTDKPIPKEYSDDETEDEIEIPKPLDKPISHPTSLVTSVTGSGDKSSLHPEEKPKSPE 6346
            .|         |:|.|..|..|.::|....|:|                        |:..:|.|
 Worm  5046 QS---------PVPSEEDDHVTHEQIIRDDPID------------------------EQIVESHE 5077

  Fly  6347 KKDEKVLPKPDDSSKSVVKT--DKPIPKEYSDDETEDEIEIPKPLDKPISHPTSLVTGVTFGVDK 6409
            .|.|..:|...||: .|::|  ..||..|..|.|.|.  ::.:..|..|...|:     .:...:
 Worm  5078 YKSESSIPSEQDST-HVIETVMSTPITSERYDPEVEK--DVVESADDEIDSSTA-----QYYKSE 5134

  Fly  6410 SPLNPEEKPNSPEKKDEKVLAKPDDISKSVVKTDKPIPKEYSDDETDDEIEIPKPLDKPICQPTS 6474
            ||:..|:         ..:|||               .::.|.||:|.|....|.|.  ..:...
 Worm  5135 SPVQTEK---------SLLLAK---------------QQQESGDESDGEGFGSKVLG--FAKKAG 5173

  Fly  6475 LVTGATFGGDGSPLHPEEKPKSPEKKDEKVLAKPDG----SSKSVVETDKPSPKEYSDDETEDKI 6535
            :|.|.                        |:|.|..    .:|:..:..|      .||:.||:.
 Worm  5174 MVAGG------------------------VVAAPVALAAVGAKAAYDALK------KDDDEEDQE 5208

  Fly  6536 D-------FPKPQDKPFKEATPSVT------PVSTIPDVKAIDFVSFKAEECSTTIQTNIKLAST 6587
            |       |.|.|| |..:..||..      |.:|.          ::.||....|..:   |.:
 Worm  5209 DKEPLIGGFHKDQD-PISQDEPSAVDSETQEPGATF----------YEPEEEDKVITDS---ADS 5259

  Fly  6588 SITTKDTKIVQPIDSL----SNLKDDKFPTSVGDKAKSPRESVKPNLKEYSD-----KEEKPDSH 6643
            |:...:.|||.|:||.    ||.::: |.:.|        :|..|.:.|.:|     .||...|.
 Worm  5260 SVVQDEPKIVFPVDSTPEHHSNDREE-FESIV--------KSEGPYIVESTDYAQTSAEEPRISS 5315

  Fly  6644 PVSLVTSVMGSGDKSPLHPEEKPKSPEKKDEK-VLPKPDDSSKSVVETDKP---SPKEYSDDETD 6704
            ||.     ..:||.|..   ::|:|...:||| .:|:..       |||.|   ..:||..:..|
 Worm  5316 PVH-----SDAGDASSF---KRPESVTGEDEKNAIPETS-------ETDAPYVIDSEEYEFNNRD 5365

  Fly  6705 DEIDIPKALDKPISHPVSLVTSVMGSGDKSPLHPEEKPKSPEKKDEKVL---------PKPDDSS 6760
            ::         .||               ||.|.:|:    ::.|.:|:         .:.::..
 Worm  5366 EQ---------RIS---------------SPAHSDEE----DENDAEVIDSEFYRHSQEQNNEED 5402

  Fly  6761 KSVVETDKPI------PKEYSDDETDDEIEIPKPLDKPISHPTSLVTGVTFGVDKSPLHPEEKPK 6819
            .|:||:.:.|      |:.:.|..|...:.        :.|..:.:             ||.:..
 Worm  5403 PSIVESGEYISSGHGSPRPFEDSTTTTVLN--------VHHEPAAI-------------PEPEVD 5446

  Fly  6820 SPEKKDEKVLAKPDDSSKSVVKTDKPIPKEYSDDENDDEIDFPKPLDKPISHPVSLVTSVMGSG- 6883
            ..|.:.|:.:.:.::     .||..|:|..........|   |..:.|..:...::||:|....
 Worm  5447 EEELEQERSIIESEE-----YKTSSPLPPTSVTTVEHVE---PAEIHKYRTTSPTIVTTVSSEHL 5503

  Fly  6884 DK---------------SPLHPEEKPKSPEKKDEKVLPKPDDSSKSVVE----TDKPIPKEYSDD 6929
            |:               |||.| |:|:||....   ||:.:|.| .|:|    |..|:|.|.|
 Worm  5504 DRNQEPYVVESEEYTRASPLGP-ERPESPSGSP---LPREEDDS-HVIESHEYTSSPVPSEDS-- 5561

  Fly  6930 ENDDEIDFPKALDKPISHTTSLVTSVTGGGDKSSLHPEEKPKSPEKKDEKVLPKPDDSSKSVVET 6994
                       :...|..||:  |:||          ||:            .:|:||
 Worm  5562 -----------VKHVIEKTTT--TTVT----------EER------------YEPEDS------- 5584

  Fly  6995 DKPSPKEYSDDETDDEIEIPKPLDKPISHPTSLVTGVTFGVDKSPLHPEEKPKSPEKKDEKVLAK 7059
            ..|.|.|       |::           |.....|..|..|......||:     ...||.|:..
 Worm  5585 HSPVPSE-------DDV-----------HGFVKTTTTTTTVTHEHFEPED-----HTSDEHVVES 5626

  Fly  7060 PDDSSKSVVKTDKPIPKEYSDDENDDEIDFPKPLDKPISHPTSLVTGVTFGGDKSSLHPEEKPKS 7124
            ...:|.|      |:|.|    ||.:.:.           .|:..|.||      ..|.|
 Worm  5627 ERYASGS------PVPSE----ENSNRVT-----------ETTTTTTVT------REHFE----- 5659

  Fly  7125 PEKKDEKVLPKPDDSSKSVVETDKPSPKEYSGDETDDEIEIPKPLDKPISHPTSLVTGVTFGVDK 7189
                       |:|..:.|||:     :|||...:      |.|.:|.:.......|..|  |.:
 Worm  5660 -----------PEDDQEHVVES-----QEYSASGS------PVPSEKSVEKVIETTTTTT--VTR 5700

  Fly  7190 SPL-HPEEKPKSPEKKDEKVLAKPDDSSKSV------VKTDKPIPKEYSDDENDDEIDSPKPLDK 7247
            ... |.:|.|...|...:...|....|.:.|      ..|...:.:|:.  ..|:||||.:.
 Worm  5701 EHFEHEDEIPTIVESSHDDQAASSVPSEEDVHGQIQTTTTTTTVTREHV--VPDEEIDSGRM--- 5760

  Fly  7248 PISHPTSLVTGATFGGDKSPLHPEEKPKSPEKKDEKVLA------------KPDDSSKSVVKTDK 7300
                            |:...:..|.|..||:...:|:.            :|:|....||
 Worm  5761 ----------------DELEKYSSESPVPPEEDSSRVIETTTTTTFIREHFEPEDDHSHVV---- 5805

  Fly  7301 PSSKEYSDDETEDEIVIPKPLDKPISHPTSLVTGATFGGDKSPLHPEEKPKSPEKKDEKVLAKPD 7365
             .|:|||...:      |.|.:|.:.......|..|...:    |.|.:.:..:..|
 Worm  5806 -GSQEYSASGS------PVPSEKSVERVIETTTTTTVTSE----HFEHEDEHAQLHD-------- 5851

  Fly  7366 DSSKSVVKTDKPSSKEYSDDETEDEIVIPKPLDKPISHPTSLVTGATFGGDKSPLHPEEKPKSPE 7430
                 .|.::|.||.|..:...|:..:..:             |...|..:     .|.:|.|.|
 Worm  5852 -----TVSSEKTSSSEPVEQTLEEADITEE-------------THQRFSAE-----DEHQPTSTE 5893

  Fly  7431 KKDEKVLAKPDDSSKSVVKTDKPIPKEYSDDENDDE----------IDFPKPLDKPISHPTSLVT 7485
            |.....:     .:.|...|...:..|:.||  |||          :.|.|.            .
 Worm  5894 KPVHGFM-----ETTSTSHTASHVELEHRDD--DDESGGEGFGSKVLGFAKK------------A 5939

  Fly  7486 GATFGGDKSPLHPEEKPKSPEKKDEKVLAKP----DDSSKSVVETDKPSPKEYSDDETDGEIDFP 7546
            |...||                    |:|.|    ...:|:..:..|      .||:.:...|
 Worm  5940 GMVAGG--------------------VVAAPVALAAVGAKAAYDALK------KDDDEEATYD-- 5976

  Fly  7547 KPLDKPISHPTSLVTSVTGSGDKSSL-HPEEKPKSPEKKDE---KVLPKPDDSSKSVVETDKPSP 7607
              ||:  .|         ||.:.:.| .|.::.:|.::..|   ..:...:||....|::.:.:.
 Worm  5977 --LDR--EH---------GSYESAELQRPTQQVESRQEDSESEGSFVDHGEDSQHLPVQSTEAAF 6028

  Fly  7608 KEYSDD---ETEDEI--EIPKPLDKPVSHPTSLLTGVTFGGDKSPLHPEEKPKSPEKKDEKVLAK 7667
            |..|:|   :|.:::  |:..|||:.:.........:.....:||:.|:.              .
 Worm  6029 KLSSEDIAEQTAEKLVSEVFAPLDRTLIESEQYRASIESLNRRSPVEPKR--------------S 6079

  Fly  7668 PDDSSKSVVETDKPIPKEYSDDETDEEIEIPKPLDKPISHPTSLVTGATFGGDKS------PLHP 7726
            .:|.:...::....|...::|:..|:.                       .||..      ..|.
 Worm  6080 VEDLASEALQNVTKISFGHADESDDKH-----------------------DGDNDGEWKVYDRHG 6121

  Fly  7727 EEKPK-SPEKKDEKVLAKPDDSSKSVVKTDKPIPKEYS-------------DDENDDEIDFPKPL 7777
            |...: |.:..|:.:.....|::..::.|.    .|||             :..|:.|:|:...|
 Worm  6122 EVLEEFSTQLTDDVIQEAEGDATTHIMMTQ----AEYSPRRSKFLKQESCQEISNEPEVDYYSDL 6182

  Fly  7778 DKPISHPTSLVTGATFGGDKSPLHP--EEKPKSPEKKDEKVLAKPDDSSKSVVETDKPSPKEYSD 7840
            .:.::         ...|:|:.||.  ||:|.|.......|:.:.|..:....|..:.:..:...
 Worm  6183 QEKLN---------ILAGEKNNLHALVEEEPSSSASDQLDVIHESDQEAHLEQEHQQEAAAQKEQ 6238

  Fly  7841 DETDGEIDFPKPLDKPISHPTSLVTSVTGSGDKSSLHPEEKPKSPEKKDEKVLPKPDDSSKSVVE 7905
            ||.:...::.         .|.||..|        |....:..:.|..|:|.:    .|:..:..
 Worm  6239 DEKEEAAEYT---------ATLLVDDV--------LQQVVQEINEEDDDKKTM----TSTSYLTA 6282

  Fly  7906 TDKPIPKEY-----SDDETDEEIEIPKPLDKPISHPTSLVTGVTFDGDKSPLHPEEKPKSPEKKD 7965
            |:|. .:||     |.|:|.|..:.....|...:..||.......|.|......:...:..|...
 Worm  6283 TEKD-DQEYDTCVTSQDDTYESAQGWTSQDSEYTTATSQAPSRLSDSDAELTARDHDQERQETST 6346

  Fly  7966 EKVLAKPDDSSKS-VVETD--KP-----SPKEY------------------SDDETDDEIEIPKP 8004
            .:.:..|.||.:. .|:.|  .|     .|.::                  .:||:||::
 Worm  6347 PQAILSPVDSDRHFTVQQDFEMPVIRAFDPDDFMQTTARSTPDVALQVTIEEEDESDDKL----- 6406

  Fly  8005 LDKPISHPTSLVTGVTFGGDKSPLHPEEKPKS--PEKKDEKVLAKPDDSSKSVVETDKPSPKEYS 8067
               ||| |:.::.        .|.|...:|.|  |.:|.:..:.|..|....|.|.|
 Worm  6407 ---PIS-PSGILL--------PPKHDPGRPISPVPPRKSDGTMQKEGDHFVFVREED-------- 6451

  Fly  8068 DDETDDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKPKSPEKKDEKVLAKPDDSSKSVV 8132
                            .|:.||                |..:|..||:..|....|..:..:.
 Worm  6452 ----------------TIAEPT----------------PPPQPAEPEQLAEYEATKESEHQQI-- 6482

  Fly  8133 KTDKSTPKEYSDDETDDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKPKSPEKKDEKVL 8197
             |:...|:|      ::|.|:.:...:.| |..::......|..:|..:..:            |
 Worm  6483 -TEGDVPQE------EEETEMRRQETERI-HSLAMEASSDLGNSESSRYSRQ------------L 6527

  Fly  8198 AKPDDSSKSVVETDKPSPKEYSDDETDDEIEIPKPLDKPISHQTSLVTGVTFGGDKSPLHPEEKP 8262
            :....|::|..:|......|.|.  :.|.:|:              |:.::.|.|.........|
 Worm  6528 SDLSSSAESHADTVIRVESERSG--SSDSLEV--------------VSVISAGKDAQMSEKSLTP 6576

  Fly  8263 KSPEKKDEKVLAKPDDSSKSVVKTDKSTPKEYSDDETDDEIDFPKPLDKPISHPTSLVTGVTFGG 8327
            :.||        ||.||.:...:.|:...:.....|.:|                       .|.
 Worm  6577 EDPE--------KPTDSVQEHQQKDQEQAEAEDQREAED-----------------------LGF 6610

  Fly  8328 DKSPLHPEEKPKSPEKKDEKVLAKPDDS-------SKSVVETDKPIPKE-------YSDDETD-- 8376
            :......||:.:..|:. |.|..:|:||       :.|...:...:|.:       |....:|
 Worm  6611 EVYDADTEEQNQQLEEL-ETVEEEPEDSDSLNEGGNHSSGHSSVGVPADTLAMIGKYRHQSSDNL 6674

  Fly  8377 -----EEIEIPKPLDKPISHPTSLVTSVTGSGDKSPSLVTSLVT---SVTGSGDKSPLHPEEKPK 8433
                 :|.|   .|:|.:        ...|.|..:.|.:..||.   :.:|.|..|.|...|:
 Worm  6675 SLTSLQEFE---RLEKEV--------GARGDGSLTRSEIELLVAGRLNKSGEGSVSSLAEFER-- 6726

  Fly  8434 SPEKKDEKVLAKPDD--SSKSVVKTDKPSSKEYSDDETEDEIVIPKPLDKPISHPTSLVTGVTFG 8496
             .||:..:..:.|:|  ....:.:..:.......||:.||                      ..|
 Worm  6727 -LEKEMTENQSPPEDVMMLSDIREESEAEDMSIRDDDEED----------------------AEG 6768

  Fly  8497 GDKSPLHPEEKPKSPEKKDEKVLA----KPDDSSKSVVETDKPSPKEYSDDETE---DEIEIPKP 8554
            .|     .|.|.:..:::|.:|:.    .|.||....|:..:....|.|.|..|   .|||:
 Worm  6769 SD-----TELKSRPVQEEDLRVITPIAPSPTDSLDHAVDAVQMQYLETSTDSLEPTFQEIEV--- 6825

  Fly  8555 LDKPVSHPTSLLTGVTFGGDKSPLHPEEKPKSPEKKDEKVLAKQDDRSKSVVETDKPIPKEYSDD 8619
                                      |::|:|.|           |.|.:..|.   ||: ..:.
 Worm  6826 --------------------------EQRPESVE-----------DTSLTEYEV---IPR-VMEA 6849

  Fly  8620 ETDDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKPKSPEKKDEKVLAKPDDRSKSVVET 8684
            .|.|.::....::|     .|::.|.:.|.:.:             :....|...|.....|.:.
 Worm  6850 STTDSLDGTATIEK-----DSVLEGASQGIEST-------------QSTHGLLSGDTMGTVVTDD 6896

  Fly  8685 DKPIPKEYSDDETDDEIEIPKPLDKPISHPTSLVTGVTFGGDGSPLHPEEKPKSPEKKDEKVLAK 8749
            |:        |..|.|:.     ....|:||:|.|..|                       .:..
 Worm  6897 DR--------DSLDGEMS-----SMLQSYPTTLTTFQT-----------------------TVVG 6925

  Fly  8750 PDDSSKSV---VETDKPSPKEYSDDETDDEIDIPKPLDKPISHPTSLVTSVTGSGDKSSLHPEEK 8811
            ||.|.:::   |||....|                           ||:.||.:|.:|.
 Worm  6926 PDGSLQTISRRVETKVTDP---------------------------LVSHVTFTGTESQ------ 6957

  Fly  8812 PKSPEKKDEKVLAKPDDSSKSVVETDKPIPKEYSDDETDDE 8852
                |:.|:    .|||.....|:|:..:.:.....|.|.:
 Worm  6958 ----ERLDQ----LPDDEQFETVDTEGNVTRTTFHREHDQQ 6990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	20/30 (67%)
		Ank_4	11..64	CDD:290365	38/52 (73%)
		ANK	38..163	CDD:238125	93/124 (75%)
		ANK repeat	43..74	CDD:293786	20/30 (67%)
		Ank_2	48..135	CDD:289560	60/86 (70%)
		ANK repeat	76..107	CDD:293786	21/30 (70%)
		ANK repeat	109..134	CDD:293786	18/24 (75%)
		Ank_4	110..163	CDD:290365	42/52 (81%)
		Ank_4	172..225	CDD:290365	42/52 (81%)
		ANK repeat	175..202	CDD:293786	22/26 (85%)
		ANK	199..324	CDD:238125	93/124 (75%)
		ANK repeat	204..235	CDD:293786	21/30 (70%)
		Ank_2	209..300	CDD:289560	61/90 (68%)
		ANK repeat	237..268	CDD:293786	20/30 (67%)
		ANK	266..390	CDD:238125	106/123 (86%)
		ANK repeat	270..300	CDD:293786	23/29 (79%)
		ANK repeat	303..367	CDD:293786	56/63 (89%)
		Ank_2	308..399	CDD:289560	77/90 (86%)
		ANK	364..489	CDD:238125	102/124 (82%)
		ANK repeat	369..400	CDD:293786	24/30 (80%)
		ANK repeat	402..433	CDD:293786	25/30 (83%)
		Ank_4	403..456	CDD:290365	43/52 (83%)
		ANK repeat	435..466	CDD:293786	25/30 (83%)
		Ank_2	440..530	CDD:289560	63/89 (71%)
		ANK	463..588	CDD:238125	81/124 (65%)
		ANK repeat	468..497	CDD:293786	22/28 (79%)
		ANK repeat	501..530	CDD:293786	16/28 (57%)
		Ank_2	506..597	CDD:289560	56/90 (62%)
		ANK	529..654	CDD:238125	84/124 (68%)
		ANK repeat	535..565	CDD:293786	16/29 (55%)
		ANK repeat	567..598	CDD:293786	22/30 (73%)
		Ank_2	572..661	CDD:289560	62/88 (70%)
		ANK repeat	600..630	CDD:293786	20/29 (69%)
		ANK repeat	633..662	CDD:293786	21/28 (75%)
		ANK	661..785	CDD:238125	77/123 (63%)
		ANK repeat	666..697	CDD:293786	21/30 (70%)
		Ank_2	672..762	CDD:289560	57/89 (64%)
		ANK repeat	699..730	CDD:293786	22/30 (73%)
		ANK repeat	732..762	CDD:293786	17/29 (59%)
		ZU5	927..1030	CDD:128514	70/102 (69%)
		Death_ank	1417..1497	CDD:260029	22/81 (27%)
		ER-remodelling	11936..>12013	CDD:258892
unc-44	NP_001367345.1	ANK repeat	32..63	CDD:293786	20/30 (67%)
		PHA03095	37..>387	CDD:222980	269/349 (77%)
		ANK repeat	65..96	CDD:293786	20/30 (67%)
		ANK repeat	98..129	CDD:293786	21/30 (70%)
		ANK repeat	131..156	CDD:293786	18/24 (75%)
		ANK repeat	197..224	CDD:293786	22/26 (85%)
		ANK repeat	226..257	CDD:293786	21/30 (70%)
		PHA02876	<242..>648	CDD:165207	301/405 (74%)
		ANK repeat	259..290	CDD:293786	20/30 (67%)
		ANK repeat	292..322	CDD:293786	23/29 (79%)
		ANK repeat	325..356	CDD:293786	27/30 (90%)
		ANK repeat	358..389	CDD:293786	26/30 (87%)
		ANK repeat	391..422	CDD:293786	24/30 (80%)
		ANK repeat	424..455	CDD:293786	25/30 (83%)
		ANK repeat	457..488	CDD:293786	25/30 (83%)
		ANK repeat	490..519	CDD:293786	22/28 (79%)
		ANK repeat	523..552	CDD:293786	16/28 (57%)
		Ank_2	555..>780	CDD:423045	148/224 (66%)
		ANK repeat	556..586	CDD:293786	17/29 (59%)
		ANK repeat	589..620	CDD:293786	22/30 (73%)
		ANK repeat	622..652	CDD:293786	20/29 (69%)
		ANK repeat	655..685	CDD:293786	21/29 (72%)
		ANK repeat	688..719	CDD:293786	21/30 (70%)
		ANK repeat	721..752	CDD:293786	22/30 (73%)
		ANK repeat	754..784	CDD:293786	17/29 (59%)
		Ank_4	756..807	CDD:372654	31/50 (62%)
		ZU5	1008..1110	CDD:128514	70/101 (69%)
		UPA_2	1337..1472	CDD:375346	78/134 (58%)
		Death_ank	1503..1580	CDD:260029	25/134 (19%)
		PTZ00449	<1770..2112	CDD:185628	96/478 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161925
Domainoid	1	1.000	282	1.000	Domainoid score	I875
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1011028at2759
OrthoFinder	1	1.000	-	-		FOG0000917
OrthoInspector	1	1.000	-	-		oto18457
orthoMCL	1	0.900	-	-		OOG6_100012
Panther	1	1.100	-	-	LDO	PTHR24123
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2336
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.970