DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank2 and C18H2.5

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_741231.2	Gene:	C18H2.5 / 176082	WormBaseID:	WBGene00015992	Length:	1195	Species:	Caenorhabditis elegans

Alignment Length:	852	Identity:	162/852 - (19%)
Similarity:	284/852 - (33%)	Gaps:	272/852 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1366 AKGEPPQQPICILNIVLPEAVIP---DSTTAFSDRVTSAYRTSMFSLSKHQNDHYIGDIRIVDLS 1427
            ||||         .::.|:.|..   |:..|....:..||.|             |..:..|.|:
Worm    16 AKGE---------GVIDPKGVSEARRDARGAVKSHLELAYET-------------INKLSRVTLA 58

  Fly  1428 NLLGKDWIQ----LAPEIG----INGEEIDEIINQNTDSIARQAQSMIRLYK---DKPNYD---- 1477
            .......||    ..|.:|    .|...:..||..|..::......::..||   :..|.|
Worm    59 IAYEAAAIQQSFKFRPALGELLEANLANLSTIITHNPLTVNNHLDGIVERYKRIYESTNGDKDDL 123

  Fly  1478 --ILSL-ETALKNIGRDDIMKKCKSGRLSHSREFDEADLMKNSESVEELVRRESKRIQQINEREE 1539
              ||.| |..:.::..|.::.|.|.        .|..|.:.|:.::..|.......::.|.|...
Worm   124 LRILKLNEDLMTSVSSDYVVNKTKI--------HDFFDHLGNNSTISRLKGCNETHVEMIVEFWN 180

  Fly  1540 VKYSAEEKEVEESESDEEAA----KRTVAERRE-------------------KIVKRLSIERSIP 1581
            |   ..||:. .:|.|::.|    |..:.|.|:                   ::.:.:...|:..
Worm   181 V---INEKKA-ANEDDKKIAIVTLKNRIPEVRQCMTSIKEYYSFVYPISKVGEVFRNIFSARATV 241

  Fly  1582 ASTQKKEITRE-----ITEIKR--KSLIEDKKA-----HHESEILMQLPADNVIIKTTTVPDQVI 1634
            ...:||:|..|     :.::|.  |.:|:|.:|     :.|..:.:||..|.|..||..|...::
Worm   242 ELFKKKQIEYENFPNDLEKLKNIAKKIIKDWEAPQVDVYKEVSMTVQLHKDMVQNKTMAVWLSLV 306

  Fly  1635 ------KMKMGKMD------STEVSKSEFDKELTHKFKTSGRSSEEEDQPSYPDQTDKIVQDISA 1687
                  .:||.:.|      ..:|:..:..|.|.:..:...:.||      |..:.:.......|
Worm   307 GYGLIEDLKMVREDLNSVWFKEKVANGKSIKFLENSLEAFFKFSE------YTGKLETTWIKFKA 365

  Fly  1688 AEKKEKDGVTFSRVTTITRQEARDI-----------------------TEDFLEIEKRSQLPATS 1729
            ..|.|:..:..|.....:..:..|:                       ||||...::.|: ..:.
Worm   366 FFKAERKNLLESLSFYSSINQCSDVASGEGAIENMKKIYNGCWKGSAQTEDFARFDEHSK-TLSD 429

  Fly  1730 TTATVHEKFV---EEIKEK-----TSPLASV---------PQETVKEVQQVISEVTEIASKKVEN 1777
            ..:|:.|...   |.:|:.     .:.|.|:         ||||:.||:::         :..|:
Worm   430 LNSTIFEVLAWCNETVKQNDFDVMETALDSLNNLNLENLNPQETINEVREI---------QNFED 485

  Fly  1778 IISSFES-------SKSVDATTVLPTQPSVESTKVSETIKNLEDAKAVSAEQVKTVHVVESSSIE 1835
            :...||.       .|..|....|..:.::... :.||..||..:|:::..:...:...:||.|.
Worm   486 LNDFFERFLRFHLLQKKYDTDYQLLHKVNLVDV-MEETAANLTKSKSIANLKCLKMKEFQSSKIH 549

  Fly  1836 ETIAEF-----------EAKKVKYDFHGGEPKTQIPKFTRKPSDDSMKPTAAPRATVESETESVL 1889
            .|: ||           :.||:|                     |::|..:..|....:..:.:.
Worm   550 STV-EFITSVRRIGNSSDHKKIK---------------------DAVKIYSDMRTDYVAVEKFLE 592

  Fly  1890 ETKAEKPISKIPVKTIPTEAQKVSEVDARKIT------QDFLQGEKLAAEPKPSP-----AASKI 1943
            ||:.:...::...|..|....|.|...|.|:.      :|.::..||.:|...|.     ...||
Worm   593 ETRRQSKQNEQLTKQNPVLKFKHSMKIATKLAKGMICLRDLIESYKLRSEILNSANYDNGVNDKI 657

  Fly  1944 PKVEPRKSVD-----------KQVDRESKILD------------------DVVASTATIMTAGLG 1979
            ......|.|.           :.|.||...|:                  ||..:.:.|....|.
Worm   658 ANFNENKQVKEFWSGSPGYLLEHVVRELDNLNMEARKYIGSDLGTIGTLFDVATNVSGIKGVDLL 722

  Fly  1980 DEQLKDQL----------------------------VDHSEIIAKSETVAEKVTELLDTFHKIEE 2016
            .|.:.|||                            |:|.::.|.||::.: :.|..|...
Worm   723 FEYVHDQLDSYDVKDKNFQMAKKNSENLAELWLDFTVNHQDLRAASESIKD-IKEYFDEIF---- 782

  Fly  2017 KVTKSEK 2023
            ||.||||
Worm   783 KVNKSEK 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786
		Ank_4	11..64	CDD:290365
		ANK	38..163	CDD:238125
		ANK repeat	43..74	CDD:293786
		Ank_2	48..135	CDD:289560
		ANK repeat	76..107	CDD:293786
		ANK repeat	109..134	CDD:293786
		Ank_4	110..163	CDD:290365
		Ank_4	172..225	CDD:290365
		ANK repeat	175..202	CDD:293786
		ANK	199..324	CDD:238125
		ANK repeat	204..235	CDD:293786
		Ank_2	209..300	CDD:289560
		ANK repeat	237..268	CDD:293786
		ANK	266..390	CDD:238125
		ANK repeat	270..300	CDD:293786
		ANK repeat	303..367	CDD:293786
		Ank_2	308..399	CDD:289560
		ANK	364..489	CDD:238125
		ANK repeat	369..400	CDD:293786
		ANK repeat	402..433	CDD:293786
		Ank_4	403..456	CDD:290365
		ANK repeat	435..466	CDD:293786
		Ank_2	440..530	CDD:289560
		ANK	463..588	CDD:238125
		ANK repeat	468..497	CDD:293786
		ANK repeat	501..530	CDD:293786
		Ank_2	506..597	CDD:289560
		ANK	529..654	CDD:238125
		ANK repeat	535..565	CDD:293786
		ANK repeat	567..598	CDD:293786
		Ank_2	572..661	CDD:289560
		ANK repeat	600..630	CDD:293786
		ANK repeat	633..662	CDD:293786
		ANK	661..785	CDD:238125
		ANK repeat	666..697	CDD:293786
		Ank_2	672..762	CDD:289560
		ANK repeat	699..730	CDD:293786
		ANK repeat	732..762	CDD:293786
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029	20/97 (21%)
		ER-remodelling	11936..>12013	CDD:258892
C18H2.5	NP_741231.2	WSN	40..108	CDD:197734	14/80 (18%)
		Ank_4	856..909	CDD:290365
		ANK	860..>924	CDD:238125
		ANK repeat	860..886	CDD:293786
		ANK repeat	888..922	CDD:293786
		BRCT	964..1044	CDD:214602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900