DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and F37A4.4

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_498471.1	Gene:	F37A4.4 / 175945	WormBaseID:	WBGene00018134	Length:	1163	Species:	Caenorhabditis elegans

Alignment Length:	1359	Identity:	247/1359 - (18%)
Similarity:	467/1359 - (34%)	Gaps:	412/1359 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1967 VASTATI--MTAGLGDEQLKDQLVDHSEIIAKSETVAEKVTELLDTFHKIEEKVTKSEKTSEISS 2029
            :.||..:  :.:|.|::|.:.||          :.:.::::.|....:.|..:.....||.:|..
Worm     7 IFSTFVVFFVASGAGEKQGESQL----------QQIYDELSILSRVTNAIALQAAALSKTVKIRE 61

  Fly  2030 KVEELVKIEEKPLSQVQPKEDKVAEKVAEVIETFHKIEEKITTADARELTRDFLSMEQQNQLPSM 2094
            .:.||:|::....|.:...:   ...:.:.::..||...:..:....:|.:|...|...|.|.:.
Worm    62 VITELLKVDNGNFSNLLSLD---PAHLVKNLDELHKKSLQAVSGSNEQLQQDLKEMIAMNGLLAA 123

  Fly  2095 PQA---AEKPLESSLTSTSASE------PESIVTV--KPSPPASKIPVVEPRKIVFDESTKPLIE 2148
            .::   .||...:||......:      .||::|:  ..|...|.:|..|..::....|.|
Worm   124 VESENYTEKATVNSLIVLKKVDEKMEICDESLITIMFNISQAMSGVPFAESDEMKIFSSMK---- 184

  Fly  2149 PEPVKTTEKKPLNERQLTADFLSMEQQTQLVSEPAKSLVE--EVMKSAEQMVEQPKQQKSLNERQ 2211
                  |.||..  .:..:.|.:..|:....:.|....:|  :.|.:.          |:|||..
Worm   185 ------TMKKAF--YKCISKFPAFMQKLYEYNYPLSGFLELNDTMNTI----------KALNELD 231

  Fly  2212 LTEDFLLMEQQTQLPSDIVKPTDKLIDGIESAAPVGDEASPFHTPKLTTSVVTQEPQQLASEYDS 2276
            :......|.|:.:.|             ..:...|||..:..:|.||..|.:|...:.:.|...:
Worm   232 IANKIPNMLQKFKTP-------------FLNILAVGDHRNKGNTGKLLQSAITLFKKTVYSNSST 283

  Fly  2277 DTFGKQATIPLGDSKIDQGLIAPVSMEPRKSLTDAEFCKSVGETITKKMSVG--VIEISDELKKI 2339
            ..|........||.|           ...|.||...|        .||:|.|  ..|:...||
Worm   284 RLFLTAGFPESGDMK-----------RVAKDLTSDWF--------KKKVSRGKSTAELETALK-- 327

  Fly  2340 ESEIPHSQTPPPTP------SDNKTDKQNEE------PELISLERDY------------LADTVT 2380
                |.:|......      ::.:.|.|.:.      |:|:|...||            ...|..
Worm   328 ----PFNQFAESMAHVFKSWNNFRDDFQTDSALLATIPDLLSQIDDYDRNVDKKKFLENFEATFR 388

  Fly  2381 TLHTTTESTLERVSAITKIEHFS-----VHNVK------SETFTRTDEPDKLLHSVVAPPDIQKL 2434
            |.....::.|::......:::||     |.:|:      ||..|..||            ....:
Worm   389 TCFKNYKNALDQGEETKFLKNFSAVYLLVRSVQAVEQWASEISTMFDE------------KAMDV 441

  Fly  2435 YSQDTTSFTEMSTSSQTPKMTTTTTMTAQIDRTKVDLTIPGQDQQKQKDLKEQ----SAVVVDA- 2494
            |.::....|..:...|..|:|........|::..:..::..|.:...|.....    |.::.||
Worm   442 YFEELEKLTPSNIKEQVEKITNFDDFLKIINKFTMLKSLQTQYESAYKTSNSSELSLSKIITDAG 506

  Fly  2495 -----------KAETEKTASDREYLEQIMGCG--------------DVRRKIMRLE------SSC 2528
                       |.::.|.....::::.:|...              ::::|::..|      :|.
Worm   507 LVDTSKCLEKDKLDSSKLLKMLQFMQHMMQLDIDYSTLKANLDNFFELKKKMLETEKLVKGFTSR 571

  Fly  2529 STESLESVG------KSSTVTPKYIGDNVPVVREVVQSMEDKICSTVVSAIPFTVQKRKPHDDDK 2587
            |..:..:.|      |.|.....::|:.:..:::::.|:::|  :|::.:..|..   |.:.:.:
Worm   572 SARAASNSGSPVLKIKDSQKHADHLGNGLLAIKKMIISLKEK--ATILKSTMFNA---KANQEIR 631

  Fly  2588 EPNIVELEKQILTPADLALEKIFKCEPPSEVVKISPIEAMSLGLKEIDEEVCEKVCEKRKSFVVA 2652
            |.|.::..|:..|....::||:           :|.:               ||:.:..||:
Worm   632 EKNPIDYIKEFWTNPGPSIEKL-----------VSDL---------------EKLEQSSKSY--- 667

  Fly  2653 EDLCETEKTLTEQVIDLNRQVDQVPAR-VFTETIERHLDLEDRDVIEALPKVREVV-QDIERKYP 2715
                              |:.|.:..| ||          ||...|..:|:|...: ...|:|
Worm   668 ------------------RKADLLTIRKVF----------EDGSKIVGIPEVFSYIDSQFEKK-- 702

  Fly  2716 AASLEAKPFSPRKRVTPDRKVDVSSLE------QQILTDADLILD----------GLGSKCVPEQ 2764
                 ...:|..:::|.    .:|:|:      :..|:.|.|.:|          ||..|...:.
Worm   703 -----GSQYSNERKITQ----ALSTLDLNFASHKGALSAASLSVDNLKLYFDDLFGLTPKVSVQS 758

  Fly  2765 KVQSPI----------------------FSSNKASSSTENLEDICEKKCSKRTISDMTKVFERQE 2807
            :..|||                      |:||..:                :.|:.....|.:..
Worm   759 ESTSPIVVVLICVAIVLVLVILAIVGYGFTSNGRN----------------QYINLYLYYFGKTS 807

  Fly  2808 DPTTMPSIKDVKSTTAKFLESESGKFAITESIQHFNAKGSINKEVAGIEKGQIRFLKDCD---TQ 2869
            |       .:.:...:.|::...||..:.:|::..||...:.    .:::|  .::..|:   ..
Worm   808 D-------YEKRWRYSLFMDRVDGKNVLIDSVREINATNLLK----AVKRG--AYINVCNKYGNT 859

  Fly  2870 EFPIETNLD-TKLVEFPKITHTLER--LHSISKTDIADTKKVVHESSEFKSKLDKLVHKTEQTDN 2931
            ...:.|... ..|||. .|.|..:|  |:..:||  |:....|:.....|.|:::........:.
Worm   860 ALHVATRRGYQNLVEI-LIKHGADRSFLNPQNKT--AEQMIPVNYQETHKEKIERFKSIESIYNK 921

  Fly  2932 QNPDKF------KFP-----------TQDNF-DELQTQ-KSLTS-ELVTMTDSSEYKFPPEG--- 2973
            ....||      |||           |.||. :|..|: :|:|| |.:..|.....|...:|
Worm   922 YRKKKFKLCVPEKFPVSSFHIYIEDRTDDNVTNEFTTKFQSITSDEAMITTTHVVVKTTEDGILE 986

  Fly  2974 ------------KSILGKEP--IESESDEELDNLNKICKLQLLSKIEQSSFI-DT-TEIANTEKR 3022
                        .||:.::.  ::...||:|  :.|.|. .|:.|::....| || |:.:|...:
Worm   987 TDDLNLLIWIFHGSIIVRDTWMVDCLRDEKL--IEKDCD-YLVEKVKYKGIIYDTVTQWSNAMAK 1048

  Fly  3023 EITKFPTTNDSHSDLFSKS-------RATLKTQSGEKTHCTHFTETISDK--NYNSFSDTS---- 3074
            ..|  |.....|..|..|:       .|.::.|.|          |:.||  :.::|:..|
Worm  1049 ATT--PFLYGVHVALCMKNCPYLASLTAIIQGQGG----------TMLDKFPDKDAFNKGSHPYL 1101

  Fly  3075 -------FLLNSVTASADKSPLHPEEK-TKSPEKKDEKVLAQPDDNFKSVIETDKPSPK 3125
                   |||:..|...|.....|::. |...|::...:|      ||..|..| .:||
Worm  1102 HKNLGPIFLLHDGTGDLDLYRSDPDKMFTLFTEQQFMDLL------FKREINKD-TNPK 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786
		Ank_4	11..64	CDD:290365
		ANK	38..163	CDD:238125
		ANK repeat	43..74	CDD:293786
		Ank_2	48..135	CDD:289560
		ANK repeat	76..107	CDD:293786
		ANK repeat	109..134	CDD:293786
		Ank_4	110..163	CDD:290365
		Ank_4	172..225	CDD:290365
		ANK repeat	175..202	CDD:293786
		ANK	199..324	CDD:238125
		ANK repeat	204..235	CDD:293786
		Ank_2	209..300	CDD:289560
		ANK repeat	237..268	CDD:293786
		ANK	266..390	CDD:238125
		ANK repeat	270..300	CDD:293786
		ANK repeat	303..367	CDD:293786
		Ank_2	308..399	CDD:289560
		ANK	364..489	CDD:238125
		ANK repeat	369..400	CDD:293786
		ANK repeat	402..433	CDD:293786
		Ank_4	403..456	CDD:290365
		ANK repeat	435..466	CDD:293786
		Ank_2	440..530	CDD:289560
		ANK	463..588	CDD:238125
		ANK repeat	468..497	CDD:293786
		ANK repeat	501..530	CDD:293786
		Ank_2	506..597	CDD:289560
		ANK	529..654	CDD:238125
		ANK repeat	535..565	CDD:293786
		ANK repeat	567..598	CDD:293786
		Ank_2	572..661	CDD:289560
		ANK repeat	600..630	CDD:293786
		ANK repeat	633..662	CDD:293786
		ANK	661..785	CDD:238125
		ANK repeat	666..697	CDD:293786
		Ank_2	672..762	CDD:289560
		ANK repeat	699..730	CDD:293786
		ANK repeat	732..762	CDD:293786
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
F37A4.4	NP_498471.1	WSN	27..95	CDD:197734	12/80 (15%)
		Ank_2	844..>893	CDD:289560	12/53 (23%)
		ANK	<844..893	CDD:238125	12/53 (23%)
		ANK repeat	856..887	CDD:293786	7/31 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900