DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and arcp-1

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	NP_001254879.1	Gene:	arcp-1 / 175486	WormBaseID:	WBGene00009375	Length:	1235	Species:	Caenorhabditis elegans

Alignment Length:	1015	Identity:	214/1015 - (21%)
Similarity:	356/1015 - (35%)	Gaps:	331/1015 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDS 72
            :|.|:..:..|.::|  ||:..|::....:....:..::|:   .||       |..|....||.
Worm   394 EGKGDQIWKAAKQSG--ERIARHVQEFRQLQNRLSTAIDAI---EKD-------EKKRLDQSVDE 446

  Fly    73 ---ATK--KGNTALHIASLAGQEEVVKLLLEHNA-----SVNVQSQNGFTPL-YMAAQEN--HDA 124
               ||:  :|...||||.|..:.|::    ||.|     .:::....|.|.| |.|.|:|  :|:
Worm   447 EVMATRDHRGMRLLHIAVLREKHEII----EHLAITFPNQIDLTDTLGRTALHYAACQQNAIYDS 507

  Fly   125 VVRLLLSNGANQSLATEDGFTPLAVAMQQGH-----DKVVAVLLES------------------- 165
            :|.|    ||.:.||.:||.|........|.     ..|.:|:|.|
Worm   508 LVDL----GARKDLADQDGITAEEYRQNPGRLLRPSSAVSSVMLRSMSTDDEFFDPDAPSEEQVE 568

  Fly   166 ----------------DTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFT------- 207
                            |.||       |:..:|..|.|::    |:.      .||.|
Worm   569 EWLATGEVLKLEQIVLDGRG-------HMLREKKTVNASS----NEF------LSGLTQYLTKID 616

  Fly   208 PLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGN-IEAKTRDG 271
            .:|.|...|:......||.:.........:.::|:|.|...|:||.|..||.:..: :.|....|
Worm   617 AIHKAVEEGDVRRVKSLIDRPLLSTARDNYGMTPIHKALLHGQTNTVRFLLGRFPSCVNATDHAG 681

  Fly   272 LTPLHCAARSGH-EQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDEVTV 335
            .||||.||...: |.::.:|.:.|.....:.|:|..|.:....|:.::.       |:..|...:
Worm   682 RTPLHYAAADPNGEHMIKVLQKSGGDAFIEDKHGHTPFYYRTHGQRLNV-------RSMKDNAVM 739

  Fly   336 DYLTA--------------LHVAAHCGHV---------RVAKLLLDRNADANARALNGFTPLHIA 377
            :.|.:              ::...|.|::         ..|.|||.||.:.:.....||
Worm   740 NQLISGQLSRPLLQDLEEDIYDWIHTGNIGKLEELVLTGYADLLLGRNHEVDDADSIGF------ 798

  Fly   378 CKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHL 442
                    :|:|.::.|.|.:        :|.|...|.:..|..|............||.:|||.
Worm   799 --------LEVLPQYQAKIQS--------IHKAVETGNLRAVKLLTDRKKLSLCRDTRGLSPLHK 847

  Fly   443 AARANQTDIIRILLRNGAQ-VDARAREQQTPLHIASRLGNVD-IVMLLLQHGAQVDATTKDMYTA 505
            |....:|||.:.|:||..| |:|..::::||||.|:.|.:.. :..::.:.||..:....:...|
Worm   848 AIVFERTDIAKYLIRNYPQSVNAMDQKKRTPLHYAAALKDGGYLYKVMRKSGADPNIYDCNGRPA 912

  Fly   506 LHIAAKEGQDEVAAVLIENGAALDAATKKGFTPLHLTA------KYGHI-KVAQLLLQKEADVDA 563
            .:.....|:.:::|:.::..|||.........|.:|.:      :.|.: |:.||:|....|
Worm   913 KYYLKHTGEIDLSAMRLDTRAALKQVLHNRVAPSYLESSIQQWLRDGQLAKLEQLVLSGCGD--- 974

  Fly   564 QGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAK-------------NGHTPLHIAARKNQMD 615
                                   ||:...|.|...:             :|   :|.:.::..:|
Worm   975 -----------------------LLQSRTSTHTETQAFLDRLPDYMDKIDG---IHKSIKEGNLD 1013

  Fly   616 IATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEH-KAAVNHPAKNGLTPMH-LCAQED 678
            ....|::...||.|..:.|.||||.:....|.||...:..| .:.:|.|..|..|.|| ..|..|
Worm  1014 KVKELMKTKKLAIARDRFGCTPLHSAVVHEHTEIVRYIAGHYNSVLNAPDYNKRTAMHYAAAARD 1078

  Fly   679 NVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQ 743
            ..:..:||.|.||:          |:.|.:
Worm  1079 GGHYLKILGKAGAD----------PMAVDN----------------------------------- 1098

  Fly   744 GHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSLKTITKEDETAAAPSQAEEKYRVV 808
                                 .|:||.:..|.    :|:| ||.|...||..
Worm  1099 ---------------------EGRTPDYYRRN----AVID-LKLIKDRDEDF------------- 1124

  Fly   809 APEAMHESFMSDSEEEGGEDNMLSDQPYRYLTVDEMKSLGDDSLPIDVTR-----DERMDSNRMT 868
              |.::|.::        ||..|.|.|   .|.|.    |.:...||..|     ||.::.:|..
Worm  1125 --ETINEEYL--------EDGPLIDSP---ATPDS----GSEGSFIDSARMLDDEDESIERHRFE 1172

  Fly   869 QSAEYASGVPPTIGEEVISPHKTQVYGSSPKATVDGVYIA 908
            ::......:|                     .:.:|||:|
Worm  1173 KAFRGKIDLP---------------------TSENGVYLA 1191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	6/30 (20%)
		Ank_4	11..64	CDD:290365	10/52 (19%)
		ANK	38..163	CDD:238125	39/142 (27%)
		ANK repeat	43..74	CDD:293786	7/33 (21%)
		Ank_2	48..135	CDD:289560	29/99 (29%)
		ANK repeat	76..107	CDD:293786	10/35 (29%)
		ANK repeat	109..134	CDD:293786	10/27 (37%)
		Ank_4	110..163	CDD:290365	20/60 (33%)
		Ank_4	172..225	CDD:290365	11/59 (19%)
		ANK repeat	175..202	CDD:293786	5/26 (19%)
		ANK	199..324	CDD:238125	32/133 (24%)
		ANK repeat	204..235	CDD:293786	8/37 (22%)
		Ank_2	209..300	CDD:289560	25/92 (27%)
		ANK repeat	237..268	CDD:293786	10/31 (32%)
		ANK	266..390	CDD:238125	29/147 (20%)
		ANK repeat	270..300	CDD:293786	10/30 (33%)
		ANK repeat	303..367	CDD:293786	14/86 (16%)
		Ank_2	308..399	CDD:289560	18/113 (16%)
		ANK	364..489	CDD:238125	32/126 (25%)
		ANK repeat	369..400	CDD:293786	6/30 (20%)
		ANK repeat	402..433	CDD:293786	5/30 (17%)
		Ank_4	403..456	CDD:290365	14/52 (27%)
		ANK repeat	435..466	CDD:293786	15/31 (48%)
		Ank_2	440..530	CDD:289560	26/91 (29%)
		ANK	463..588	CDD:238125	23/132 (17%)
		ANK repeat	468..497	CDD:293786	8/29 (28%)
		ANK repeat	501..530	CDD:293786	6/28 (21%)
		Ank_2	506..597	CDD:289560	17/97 (18%)
		ANK	529..654	CDD:238125	27/144 (19%)
		ANK repeat	535..565	CDD:293786	8/36 (22%)
		ANK repeat	567..598	CDD:293786	4/30 (13%)
		Ank_2	572..661	CDD:289560	20/102 (20%)
		ANK repeat	600..630	CDD:293786	6/29 (21%)
		ANK repeat	633..662	CDD:293786	9/29 (31%)
		ANK	661..785	CDD:238125	21/124 (17%)
		ANK repeat	666..697	CDD:293786	11/31 (35%)
		Ank_2	672..762	CDD:289560	10/90 (11%)
		ANK repeat	699..730	CDD:293786	2/30 (7%)
		ANK repeat	732..762	CDD:293786	0/29 (0%)
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
arcp-1	NP_001254879.1	ANK repeat	73..104	CDD:293786
		Ank_2	<76..141	CDD:372319
		PHA03095	<100..>291	CDD:222980
		ANK repeat	106..141	CDD:293786
		ANK repeat	225..251	CDD:293786
		ANK repeat	253..285	CDD:293786
		Ank_2	460..>503	CDD:393464	15/46 (33%)
		ANK repeat	460..487	CDD:293786	9/30 (30%)
		ANK repeat	489..519	CDD:293786	13/33 (39%)
		ANK repeat	617..644	CDD:293786	5/26 (19%)
		Ank_2	618..712	CDD:372319	25/93 (27%)
		ANK repeat	646..678	CDD:293786	10/31 (32%)
		ANK repeat	680..712	CDD:293786	10/31 (32%)
		Ank_2	812..906	CDD:372319	28/93 (30%)
		ANK repeat	812..838	CDD:293786	5/25 (20%)
		ANK repeat	840..872	CDD:293786	15/31 (48%)
		ANK repeat	874..906	CDD:293786	8/31 (26%)
		PHA02875	895..>1073	CDD:165206	42/206 (20%)
		Ank_2	1003..1097	CDD:372319	29/103 (28%)
		ANK repeat	1003..1029	CDD:293786	6/25 (24%)
		ANK repeat	1031..1063	CDD:293786	10/31 (32%)
		ANK repeat	1065..1097	CDD:293786	12/41 (29%)
		Dpy-30	1189..1224	CDD:310056	2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910