DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and ANKAR

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:XP_011508975.1 Gene:ANKAR / 150709 HGNCID:26350 Length:1445 Species:Homo sapiens


Alignment Length:1099 Identity:211/1099 - (19%)
Similarity:372/1099 - (33%) Gaps:352/1099 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   503 YTALHIAAKEGQDEVAAVLIENGAALD----AATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDA 563
            ||..|.||...:..:...|......::    ....:|.|||||.|:...::....||..:||...
Human   534 YTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTL 598

  Fly   564 QGKNGVTPLHVACHYNNQQVALLLLEKGAS---PHATAKNGHTPLHIAARKNQMDIATTLLEYGA 625
            ..|.|..|:|.|..|:|..:.:.|..|..|   ..|||:|..|||.:||....:|....|...||
Human   599 SEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGA 663

  Fly   626 LANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHP-----------------AKNGLTPMHL 673
            ........|...:|||....|.|:...:|:    :|.|                 .:..:..|.|
Human   664 NWRKTDIKGNNIIHLSVLTFHTEVLKYIIK----LNIPELPVWKTLVEMLQCESYKRRMMAVMSL 724

  Fly   674 ---CAQEDN--------------VNVAEILEKNGANIDMATKAGYTPLHVASH----------FG 711
               |...|.              :|:.:     .:.|.:..|......::::|          .|
Human   725 EVICLANDQYWRCILDAGTIPALINLLK-----SSKIKLQCKTVGLLSNISTHKSAVHALVEAGG 784

  Fly   712 QANMVRFLLQNGANVDAATSIGYTPLHQTAQ----------QGHCHIVNLLLEHKANANAQTVNG 766
            ..:::..|:.:...|.:..::   .|:..||          .|...::|||     |.|.:.|  
Human   785 IPSLINLLVCDEPEVHSRCAV---ILYDIAQCENKDVIAKYNGIPSLINLL-----NLNIENV-- 839

  Fly   767 QTPLHIARKLGYISVLDSLKT--ITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDN 829
                       .::|::.::.  |..|:...|........|.:        .|:|   .:.|..|
Human   840 -----------LVNVMNCIRVLCIGNENNQRAVREHKGLPYLI--------RFLS---SDSGLFN 882

  Fly   830 MLSDQPYRYLTVDEMKSLGDDSLPIDVTRDERMDSNRMTQSAEYASG-VPPTI----GEEVISPH 889
            :..:.     ..|.:|::...:: .:|.||     |:..|.|....| :||.:    |:::    
Human   883 LFLNS-----FEDVLKAVSSAAI-AEVGRD-----NKEIQDAIAMEGAIPPLVALFKGKQI---- 932

  Fly   890 KTQVYGSSPKATVDGVYIANGSGHDEPPHVGRKLSWKSF------------LVSFLVDAR----- 937
            ..|:.|:        :.:.:.:.|:       .|..|:|            |.:|.:|.:     
Human   933 SVQMKGA--------MAVESLASHN-------ALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAV 982

  Fly   938 ------GGAMRGCRHSG--------VRMIIPSRSTCQPTRVTCRYV---------KPQRTMHPPQ 979
                  |..::..::..        :.|::...:..|       ||         |..| ||..|
Human   983 ALWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQ-------YVGGEAVIALSKDSR-MHQNQ 1039

  Fly   980 LMEGEALAS--RVLELGPCS-------TKFIGPVVMEVPHFASLRGKEREIIILRSDNG-----E 1030
            :.||..:|.  |:|.:...:       .:.:|.:.:.|.|.::  ...:::::  .:|.     :
Human  1040 ICEGNGIAPLVRLLRISTIAEGTLLSVIRAVGSICIGVAHTSN--PVSQQLVV--DENAFPVLIQ 1100

  Fly  1031 TWREHTIDNSEEII----------HDVLQ------QCFEPEEIAQLEEQAGNHVCRFVTYDFPQY 1079
            ..|.|...|.:..:          :||||      :.||..::..|.......:|....|.. ..
Human  1101 LLRNHPSPNIKVEVAFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYAL-TL 1164

  Fly  1080 FAVVSRIRQEVHAIGPEGGM--------VSSTV-VPQVQAVFPQGALTKKIKVGLQAQPVDPD-L 1134
            ||..:|.:|  :.|...|.|        :.||| ..:..|.|....|.|.|:        |.| :
Human  1165 FAFNNRFQQ--YLILESGIMTISIFERFLESTVETEKAMAAFQIVVLAKVIR--------DMDHI 1219

  Fly  1135 TAKLLGRGVAVSPIVTVEPRRRKFHKAITLSMPAPKAHSQGMINQYSGNTPTLRLLC-SITGGPS 1198
            |....|..:.|..:.:|:...    ..:|.::.|..|||:..|.:......|::.|| .:..|  
Human  1220 TLSARGVTILVDSLYSVQTST----IVLTGNLIASLAHSRAGIPEAFTTLGTIQRLCYHLYSG-- 1278

  Fly  1199 RAQWEDVTGSTPLTFVNDCVS----FTTTVSA-RFWLMDCRN-ISDATKMATELYKEVIHVPFIA 1257
               .|:|..:        |.|    .|...:| |..|.:||| .:...::...:.::.       
Human  1279 ---IEEVRAA--------CSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDA------- 1325

  Fly  1258 KFVVFAKKVEPFEAKLRVFCMTDDREDKTLEKHELYTEVAKSRDVEVLEGKPQY-IEMAG--NLV 1319
                   .:.|  |.|:.|.|.                       :.|.|.|.. :|..|  :::
Human  1326 -------SINP--AFLKEFQMQ-----------------------QTLVGLPSLSLEKNGGPSII 1358

  Fly  1320 PVTKSGDQLQVQFKAFRENRLPFTVRVKDQHADIVGRTLFM---KEPKVAKGEPPQQPICILNIV 1381
            |:.|.|.:        ...:|...::.||....:...|.||   |..|..|              
Human  1359 PIFKRGKE--------HRRKLKPKIQPKDSLTLLPPVTNFMGLFKATKKTK-------------- 1401

  Fly  1382 LPEAVIPDSTTAFSDRVTSAYRTSMFSLSKHQNDHYIGDIRIVDLSNLLGKDWIQLAPE 1440
                   ||...||  .:|...:.:.::|:.         |||.| |.|||...:..||
Human  1402 -------DSHNIFS--FSSTITSDITNVSRP---------RIVCL-NQLGKHVQKANPE 1441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786
Ank_4 11..64 CDD:290365
ANK 38..163 CDD:238125
ANK repeat 43..74 CDD:293786
Ank_2 48..135 CDD:289560
ANK repeat 76..107 CDD:293786
ANK repeat 109..134 CDD:293786
Ank_4 110..163 CDD:290365
Ank_4 172..225 CDD:290365
ANK repeat 175..202 CDD:293786
ANK 199..324 CDD:238125
ANK repeat 204..235 CDD:293786
Ank_2 209..300 CDD:289560
ANK repeat 237..268 CDD:293786
ANK 266..390 CDD:238125
ANK repeat 270..300 CDD:293786
ANK repeat 303..367 CDD:293786
Ank_2 308..399 CDD:289560
ANK 364..489 CDD:238125
ANK repeat 369..400 CDD:293786
ANK repeat 402..433 CDD:293786
Ank_4 403..456 CDD:290365
ANK repeat 435..466 CDD:293786
Ank_2 440..530 CDD:289560 6/30 (20%)
ANK 463..588 CDD:238125 24/88 (27%)
ANK repeat 468..497 CDD:293786
ANK repeat 501..530 CDD:293786 6/30 (20%)
Ank_2 506..597 CDD:289560 25/97 (26%)
ANK 529..654 CDD:238125 40/131 (31%)
ANK repeat 535..565 CDD:293786 11/29 (38%)
ANK repeat 567..598 CDD:293786 10/33 (30%)
Ank_2 572..661 CDD:289560 27/91 (30%)
ANK repeat 600..630 CDD:293786 10/29 (34%)
ANK repeat 633..662 CDD:293786 7/28 (25%)
ANK 661..785 CDD:238125 24/177 (14%)
ANK repeat 666..697 CDD:293786 6/47 (13%)
Ank_2 672..762 CDD:289560 19/126 (15%)
ANK repeat 699..730 CDD:293786 4/40 (10%)
ANK repeat 732..762 CDD:293786 9/39 (23%)
ZU5 927..1030 CDD:128514 23/156 (15%)
Death_ank 1417..1497 CDD:260029 10/24 (42%)
ER-remodelling 11936..>12013 CDD:258892
ANKARXP_011508975.1 Ank_2 505..598 CDD:289560 17/63 (27%)
ANK 527..658 CDD:238125 37/123 (30%)
ANK repeat 533..567 CDD:293786 6/32 (19%)
ANK repeat 570..600 CDD:293786 11/29 (38%)
Ank_2 574..669 CDD:289560 31/94 (33%)
ANK repeat 602..636 CDD:293786 10/33 (30%)
ANK repeat 638..663 CDD:293786 8/24 (33%)
ARM <678..771 CDD:237987 14/101 (14%)
armadillo repeat 703..727 CDD:293788 2/23 (9%)
armadillo repeat 737..769 CDD:293788 3/36 (8%)
ARM 738..851 CDD:237987 18/138 (13%)
armadillo repeat 776..812 CDD:293788 4/38 (11%)
armadillo repeat 816..850 CDD:293788 8/51 (16%)
ARM 817..947 CDD:237987 30/181 (17%)
armadillo repeat 858..898 CDD:293788 8/55 (15%)
armadillo repeat 1005..1029 CDD:293788 4/30 (13%)
armadillo repeat 1037..1075 CDD:293788 7/37 (19%)
ARM 1039..1166 CDD:237987 22/131 (17%)
armadillo repeat 1086..1121 CDD:293788 4/36 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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