DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and ASB10

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:NP_001135931.2 Gene:ASB10 / 136371 HGNCID:17185 Length:467 Species:Homo sapiens


Alignment Length:350 Identity:108/350 - (30%)
Similarity:157/350 - (44%) Gaps:83/350 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   297 ISAKTKNGLAPLHMAAQGE---------HVDAARI--LLYHRAPVDEVTVDYLTALHVAAHCGHV 350
            |.|.:..||||..:....:         ::.|.|:  |.|.    :|:|    |.|||||..||.
Human    73 ILADSSTGLAPDSVFDTSDPERWRDFRFNIRALRLWSLTYE----EELT----TPLHVAASRGHT 129

  Fly   351 RVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGC 415
            .|.:|||.|.|..:: |..|.|.||.||                              .|....|
Human   130 EVLRLLLRRRARPDS-APGGRTALHEAC------------------------------AAGHTAC 163

  Fly   416 MNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQVDARA-REQQTPLHIASRL 479
            :::   ||...|.|::....|:.||||.......:...:|||.||:||.|: .|::||||:|:||
Human   164 VHV---LLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARL 225

  Fly   480 GNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAALDA-ATKKGFTPLHLTA 543
            |:|::..|||:.||..||...:.:|.|          :||..:...:..|| ||         ||
Human   226 GHVELADLLLRRGACPDARNAEGWTPL----------LAACDVRCQSITDAEAT---------TA 271

  Fly   544 KYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIA 608
            :.  :::..|||...||.||..::...|||:||...:..|..|||..|.|.:.....||||||.|
Human   272 RC--LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCA 334

  Fly   609 AR-------KNQMDIATTLLEYGAL 626
            .:       ::...:...||.:||:
Human   335 LQGPAAALAQSPEHVVRALLNHGAV 359

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786
Ank_4 11..64 CDD:290365
ANK 38..163 CDD:238125
ANK repeat 43..74 CDD:293786
Ank_2 48..135 CDD:289560
ANK repeat 76..107 CDD:293786
ANK repeat 109..134 CDD:293786
Ank_4 110..163 CDD:290365
Ank_4 172..225 CDD:290365
ANK repeat 175..202 CDD:293786
ANK 199..324 CDD:238125 8/37 (22%)
ANK repeat 204..235 CDD:293786
Ank_2 209..300 CDD:289560 1/2 (50%)
ANK repeat 237..268 CDD:293786
ANK 266..390 CDD:238125 33/103 (32%)
ANK repeat 270..300 CDD:293786 1/2 (50%)
ANK repeat 303..367 CDD:293786 24/74 (32%)
Ank_2 308..399 CDD:289560 27/101 (27%)
ANK 364..489 CDD:238125 37/125 (30%)
ANK repeat 369..400 CDD:293786 6/30 (20%)
ANK repeat 402..433 CDD:293786 6/30 (20%)
Ank_4 403..456 CDD:290365 11/52 (21%)
ANK repeat 435..466 CDD:293786 12/30 (40%)
Ank_2 440..530 CDD:289560 32/90 (36%)
ANK 463..588 CDD:238125 43/126 (34%)
ANK repeat 468..497 CDD:293786 15/28 (54%)
ANK repeat 501..530 CDD:293786 4/28 (14%)
Ank_2 506..597 CDD:289560 27/91 (30%)
ANK 529..654 CDD:238125 35/105 (33%)
ANK repeat 535..565 CDD:293786 9/29 (31%)
ANK repeat 567..598 CDD:293786 11/30 (37%)
Ank_2 572..661 CDD:289560 21/61 (34%)
ANK repeat 600..630 CDD:293786 11/33 (33%)
ANK repeat 633..662 CDD:293786
ANK 661..785 CDD:238125
ANK repeat 666..697 CDD:293786
Ank_2 672..762 CDD:289560
ANK repeat 699..730 CDD:293786
ANK repeat 732..762 CDD:293786
ZU5 927..1030 CDD:128514
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
ASB10NP_001135931.2 ANK 1 115..144 16/32 (50%)
Ank_4 117..168 CDD:316185 24/88 (27%)
ANK repeat 118..145 CDD:293786 14/27 (52%)
ANK 2 147..176 12/61 (20%)
ANK 148..256 CDD:238125 45/150 (30%)
ANK repeat 148..178 CDD:293786 12/62 (19%)
ANK repeat 180..212 CDD:293786 13/31 (42%)
ANK 3 180..209 11/28 (39%)
ANK 213..>358 CDD:238125 54/165 (33%)
ANK repeat 214..245 CDD:293786 17/30 (57%)
ANK 4 214..243 15/28 (54%)
ANK repeat 247..324 CDD:293786 28/97 (29%)
ANK 5 247..289 15/62 (24%)
ANK 6 293..322 11/28 (39%)
ANK 7 326..361 11/33 (33%)
ANK repeat 326..358 CDD:293786 9/31 (29%)
SOCS 421..>439 CDD:321974
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24123
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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