DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and Ank1

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:XP_006509052.1 Gene:Ank1 / 11733 MGIID:88024 Length:1950 Species:Mus musculus


Alignment Length:2013 Identity:856/2013 - (42%)
Similarity:1209/2013 - (60%) Gaps:217/2013 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 QGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDS 72
            :.|..||||||||:|||::.|:||:|.:||||.|.||||.||||||:||:.:|.|||.:..|:::
Mouse    60 KADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 124

  Fly    73 ATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQS 137
            .|||||||||||:||||:|||:.|:.:.|:||.|||.|||||||||||||..||:.||.|||||:
Mouse   125 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 189

  Fly   138 LATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTS 202
            :||||||||||||:||||:.|||.|:...|:||||||||||||:.||.:.|.:||.||.||||.|
Mouse   190 VATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS 254

  Fly   203 KSGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAK 267
            |:||||||||:||.|.|:|.||:.:||.||::.::.|:|||:|::.|...||.|||::|..||.:
Mouse   255 KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETR 319

  Fly   268 TRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYHRAPVDE 332
            |:|.|||||||||:||.::.::||:.||||.|||||||:|:||||||:|:|..|:||.:.|.:|:
Mouse   320 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYNAEIDD 384

  Fly   333 VTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLRHGASIS 397
            :|:|:||.|||||||||.||||:|||:.|..|:||||||||||||||||.::|:||||:.||||.
Mouse   385 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHIRVMELLLKTGASID 449

  Fly   398 ATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILLRNGAQV 462
            |.|||||||||||:|||.:.||..|||..|||:|..|:.|||||:||||..|::.:.||:|.|:.
Mouse   450 AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKA 514

  Fly   463 DARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQDEVAAVLIENGAA 527
            :|:|::.|||||.|:|:|:..:|.|||::||..:..|...:|.||.||:||..:.|..|:|..|:
Mouse   515 NAKAKDDQTPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLHTAAREGHVDTALALLEKEAS 579

  Fly   528 LDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGA 592
            ....|||||||||:.||||.:::|:|||:.:|..:|.||||:||||||.|:||..:..|||.:|.
Mouse   580 QACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG 644

  Fly   593 SPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQEGHAEISNLLIEHK 657
            |||:.|.||:|||||||::||:::|.:||:||..|||||..|.|||||::||||.|:..||:..:
Mouse   645 SPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGHTEMVALLLSKQ 709

  Fly   658 AAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQN 722
            |..|...|:||||:||.:||.:|.||::|.|:|..:|..|:.||||||||||:|...:|:||||:
Mouse   710 ANGNLGNKSGLTPLHLVSQEGHVPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVKFLLQH 774

  Fly   723 GANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIARKLGYISVLDSLKT 787
            .|:|:|.|.:||:||||.|||||..||.|||::.|:.|..:.||.|||.||::||||||.|.||.
Mouse   775 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVTDVLKV 839

  Fly   788 ITKEDETAAAPSQAEEKYRVVAPEAMHESFMSDSEEEGGEDNMLSDQPYRYLTVDEMKSLGDDSL 852
            :|  |||:..  ...:|:|:..||.:.| .:..||:||               ...:..:||:.:
Mouse   840 VT--DETSVV--LVSDKHRMSYPETVDE-ILDVSEDEG---------------TAHISIMGDELV 884

  Fly   853 PIDVTRDERMDSNRMTQSAEYASGVPPTIGEEVISPHKTQVYGSSPKATVDGVYIAN------GS 911
            .   ::.||.||..:.:..|....| |.:.:.|.||...::    |..|.:.|.|.:      ..
Mouse   885 G---SKAERRDSRDVGEEKELLDFV-PKLDQVVESPAIPRI----PCVTPETVVIRSEDQEQASK 941

  Fly   912 GHDE---------------------PPHVGRKLSWKSFLVSFLVDARGGAMRGCRHSGVRMIIPS 955
            .:||                     |.|.|       |||||:||||||:|||.||:|:|::||.
Mouse   942 EYDEDSLIPSSPATETSDNISPVASPVHTG-------FLVSFMVDARGGSMRGSRHNGLRVVIPP 999

  Fly   956 RSTCQPTRVTCRYVKPQRTMHPPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKERE 1020
            |:...|||:|||.||||:...||.|.|.|.||||::.|||...:|:.||::|:|||||....:||
Mouse  1000 RTCAAPTRITCRLVKPQKLNTPPPLAEEEGLASRIIALGPTGAQFLSPVIVEIPHFASHGRGDRE 1064

  Fly  1021 IIILRSDNGETWREHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSR 1085
            :::|||:||..|:||.....|..:..:|...  .||:..|||.....|||.:|.|||.||.::||
Mouse  1065 LVVLRSENGSVWKEHKSRYGESYLDQILNGM--DEELGSLEELEKKRVCRIITTDFPLYFVIMSR 1127

  Fly  1086 IRQEVHAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQAQPVDPDLTAKLLGRGVAVSPIVT 1150
            :.|:...||||||.:.|.:||.|||.||:.|:|||:|:.||||||..:|..||||.....|||||
Mouse  1128 LCQDYDTIGPEGGSLRSKLVPLVQATFPENAVTKKVKLALQAQPVPDELVTKLLGNQATFSPIVT 1192

  Fly  1151 VEPRRRKFHKAITLSMPAPKAHSQGMINQYSGNTPTLRLLCSITGGPSRAQWEDVTGSTPLTFVN 1215
            |||||||||:.|.|.:|.|.:.:....:...|:|.:||||||:.||..:|||||:||:|.|.:.|
Mouse  1193 VEPRRRKFHRPIGLRIPLPPSWTDNPRDSGEGDTTSLRLLCSVIGGTDQAQWEDITGTTKLIYAN 1257

  Fly  1216 DCVSFTTTVSARFWLMDCRNISDATKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKLRVFCMTD 1280
            :|.:|||.|||||||.||...::|...||.||||:..||::||||:|||..:..|.:||.:||||
Mouse  1258 ECANFTTNVSARFWLSDCPRTAEAVHFATLLYKELTAVPYMAKFVIFAKMNDAREGRLRCYCMTD 1322

  Fly  1281 DREDKTLEKHELYTEVAKSRDVEVLEGKPQYIEMAGNLVPVTKSGDQLQVQFKAFRENRLPFTVR 1345
            |:.|||||:||.:.|||:|||:|||||.|.:.|::||||||.|:..|....|::||||||...|:
Mouse  1323 DKVDKTLEQHENFVEVARSRDIEVLEGMPLFAELSGNLVPVKKAAQQRSFHFQSFRENRLAIPVK 1387

  Fly  1346 VKDQHADIVGRTLFMKEPKVAKGEPPQQPICILNIVLPEAVIPDSTTAFSDRVTSAYRTSMFSLS 1410
            |:|...:..|...|::  |..|.|..|..:|.|||.:|...  ..:.|...|.|....|..:|:.
Mouse  1388 VRDSSREPGGFLSFLR--KTMKYEDTQHILCHLNITMPPCT--KGSGAEDRRRTLTPLTLRYSIL 1448

  Fly  1411 KHQNDHYIGD-----IRIVDLSNLLGKDWIQLAPEIGINGEEIDEIINQNTDSIARQAQSMIRLY 1470
            ......:..|     :|:..:...||..|.:||.|:..:.|:|:.|..:|.:|:..|:.:::.|:
Mouse  1449 SESRLGFTSDTDRVEMRMAVIREHLGLSWAELARELQFSVEDINRIRVENPNSLLDQSTALLTLW 1513

  Fly  1471 KDK--PNYDILSLETALKNIGRDDIMKKCK-SGRLSHSREFDEADLMKNSESVEELVRRESKRIQ 1532
            .|:  .|..:.:|.|||:||.|.:|:...: |||.|                      |..|..:
Mouse  1514 VDREGENAKMENLYTALRNIDRSEIVNMLEGSGRQS----------------------RNLKPER 1556

  Fly  1533 QINEREEVKYSAEEKEVEESESDEEAAKRTVAERREKIVKRLSIERSIPASTQKKEITREITEIK 1597
            :..:||   ||....:|....|           .:::::...|::.::|:.....:...|:..|.
Mouse  1557 RHGDRE---YSLSPSQVNGYSS-----------LQDELLSPASLQYALPSPLCADQYWNEVAVID 1607

  Fly  1598 RKSLIEDKKAHHESEILMQLPADNVIIKTTTVPDQVIKMKMGKMDSTEVSKSEFDKELTHKFKTS 1662
            ...|     |..|.:.:::: :|..:......|..|    ..:..|.|.||:| |.:...::|..
Mouse  1608 AIPL-----AATEHDTMLEM-SDMQVWSAGLTPSLV----TAEDSSLECSKAE-DSDAIPEWKLE 1661

  Fly  1663 GRSSEEEDQPSYPDQTDKIVQDISAAEKKEKDGVTFSRVTTITRQEARDITEDFLEIEKRSQLPA 1727
            |..||:...|....|  .:|:|.:.      |....:.:..:..||....:|     :||.::..
Mouse  1662 GAHSEDTQGPELGSQ--DLVEDDTV------DSDATNGLADLLGQEEGQRSE-----KKRQEVSG 1713

  Fly  1728 TSTTATVHEKFVEEIKEKTSPLASVPQETVKEV------QQVISEVTEIASKKVENIISSFESSK 1786
            |.                        |:|..||      |:|.:.:|:  |..|..::.. ..::
Mouse  1714 TE------------------------QDTETEVSLVSGQQRVHARITD--SPSVRQVLDR-SQAR 1751

  Fly  1787 SVD----ATTVLPTQPSVESTKVSETIKNLEDAKAVSAEQVKTVHVVESSSIEETIAEFEAKKVK 1847
            ::|    .:|.:..|.:.:|:...|..:.....:    .::.|:...|..:::    |:|...|.
Mouse  1752 TLDWDKQGSTAVHPQEATQSSWQEEVTQGPHSFQ----RRITTIQGPEPGALQ----EYEQVLVS 1808

  Fly  1848 YDFH--GGEPKTQIPKFTRKPS-------------DDSMKPTAAPRATVESETESVLETKAEKPI 1897
            ...|  .|.|:|..||..::||             .|.::.....:.|.|..|:.......:|.|
Mouse  1809 TREHVQRGPPETGSPKAGKEPSLWAPESAFSQEVQGDELQNIPGEQVTEEQFTDEQGNIVTKKII 1873

  Fly  1898 SKIPVKTIPTEAQKVSEVDARKITQDFLQGEKLAAE-PKPSP--------AASKIPKVEPRKS 1951
            .|:           |.:||:.... |..|.|::..| |...|        :..|:.|||.|.|
Mouse  1874 RKV-----------VRQVDSSGAI-DTQQHEEVIVEGPLADPGDLEADIESFMKLTKVELRGS 1924

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786 20/30 (67%)
Ank_4 11..64 CDD:290365 34/52 (65%)
ANK 38..163 CDD:238125 86/124 (69%)
ANK repeat 43..74 CDD:293786 17/30 (57%)
Ank_2 48..135 CDD:289560 57/86 (66%)
ANK repeat 76..107 CDD:293786 20/30 (67%)
ANK repeat 109..134 CDD:293786 18/24 (75%)
Ank_4 110..163 CDD:290365 41/52 (79%)
Ank_4 172..225 CDD:290365 36/52 (69%)
ANK repeat 175..202 CDD:293786 17/26 (65%)
ANK 199..324 CDD:238125 73/124 (59%)
ANK repeat 204..235 CDD:293786 19/30 (63%)
Ank_2 209..300 CDD:289560 48/90 (53%)
ANK repeat 237..268 CDD:293786 14/30 (47%)
ANK 266..390 CDD:238125 81/123 (66%)
ANK repeat 270..300 CDD:293786 18/29 (62%)
ANK repeat 303..367 CDD:293786 39/63 (62%)
Ank_2 308..399 CDD:289560 60/90 (67%)
ANK 364..489 CDD:238125 77/124 (62%)
ANK repeat 369..400 CDD:293786 23/30 (77%)
ANK repeat 402..433 CDD:293786 21/30 (70%)
Ank_4 403..456 CDD:290365 31/52 (60%)
ANK repeat 435..466 CDD:293786 15/30 (50%)
Ank_2 440..530 CDD:289560 39/89 (44%)
ANK 463..588 CDD:238125 61/124 (49%)
ANK repeat 468..497 CDD:293786 14/28 (50%)
ANK repeat 501..530 CDD:293786 11/28 (39%)
Ank_2 506..597 CDD:289560 49/90 (54%)
ANK 529..654 CDD:238125 73/124 (59%)
ANK repeat 535..565 CDD:293786 16/29 (55%)
ANK repeat 567..598 CDD:293786 18/30 (60%)
Ank_2 572..661 CDD:289560 50/88 (57%)
ANK repeat 600..630 CDD:293786 18/29 (62%)
ANK repeat 633..662 CDD:293786 14/28 (50%)
ANK 661..785 CDD:238125 70/123 (57%)
ANK repeat 666..697 CDD:293786 15/30 (50%)
Ank_2 672..762 CDD:289560 50/89 (56%)
ANK repeat 699..730 CDD:293786 19/30 (63%)
ANK repeat 732..762 CDD:293786 18/29 (62%)
ZU5 927..1030 CDD:128514 58/102 (57%)
Death_ank 1417..1497 CDD:260029 25/86 (29%)
ER-remodelling 11936..>12013 CDD:258892
Ank1XP_006509052.1 ANK repeat 454..485 CDD:293786 21/30 (70%)
ANK repeat 487..518 CDD:293786 15/30 (50%)
ANK repeat 520..549 CDD:293786 14/28 (50%)
ANK repeat 554..584 CDD:293786 11/29 (38%)
ANK repeat 586..617 CDD:293786 17/30 (57%)
Ank_2 597..>810 CDD:393464 118/212 (56%)
ANK repeat 619..647 CDD:293786 16/27 (59%)
ANK repeat 652..682 CDD:293786 18/29 (62%)
ANK repeat 685..716 CDD:293786 15/30 (50%)
ANK repeat 718..749 CDD:293786 15/30 (50%)
ANK repeat 751..782 CDD:293786 19/30 (63%)
ANK repeat 784..812 CDD:293786 17/27 (63%)
Ank_4 785..837 CDD:372654 32/51 (63%)
ZU5 970..1074 CDD:128514 59/110 (54%)
UPA_2 1295..1424 CDD:375346 65/130 (50%)
Death_ank1 1460..1543 CDD:260067 24/82 (29%)
ANK repeat 65..93 CDD:293786 19/27 (70%)
Ank_2 67..158 CDD:372319 57/90 (63%)
ANK repeat 95..126 CDD:293786 17/30 (57%)
ANK repeat 129..159 CDD:293786 19/29 (66%)
PHA02876 <141..>486 CDD:165207 223/344 (65%)
ANK repeat 161..192 CDD:293786 22/30 (73%)
ANK repeat 194..218 CDD:293786 17/23 (74%)
ANK repeat 227..254 CDD:293786 17/26 (65%)
ANK repeat 257..287 CDD:293786 19/29 (66%)
ANK repeat 289..320 CDD:293786 14/30 (47%)
ANK repeat 322..353 CDD:293786 19/30 (63%)
ANK repeat 355..386 CDD:293786 17/30 (57%)
ANK repeat 391..419 CDD:293786 19/27 (70%)
ANK repeat 421..452 CDD:293786 23/30 (77%)
PHA02875 433..>643 CDD:165206 112/209 (54%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167848329
Domainoid 1 1.000 139 1.000 Domainoid score I4761
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1011028at2759
OrthoFinder 1 1.000 - - FOG0000917
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100012
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2336
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.680

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