DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ank2 and FPGT-TNNI3K

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:NP_001106279.3 Gene:FPGT-TNNI3K / 100526835 HGNCID:42952 Length:936 Species:Homo sapiens


Alignment Length:452 Identity:131/452 - (28%)
Similarity:204/452 - (45%) Gaps:69/452 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 NIEAKTRDGLTPLH-CAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYH 326
            |:..:|.:||:.|| |....|.:..:..|:.:|...|..|:||...||:|...::.:....||:.
Human   160 NLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224

  Fly   327 RAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELLLR 391
            .|.:.:|....|||||:|...||:..|.:||...|:.|.:....|||||||......:|..|||:
Human   225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLK 289

  Fly   392 HGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQTDIIRILL 456
            .||.::.:.|.|..|||:|:..|.:||.                                 ::|:
Human   290 FGADVNVSGEVGDRPLHLASAKGFLNIA---------------------------------KLLM 321

  Fly   457 RNGAQVDARAR--EQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMY--TALHIAAKEGQDEV 517
            ..|::.|..|:  |...|||..||.|:.|||..|||...:|.....::|  |.||:|...|:.||
Human   322 EEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEV 386

  Fly   518 AAVLIENGAALDAATKKGF---TPLHLTAKYG-HIKVAQLLL-QKEADVDAQGKNGVTPLHVACH 577
            |..:|:. :..::.||:..   |..|....|| .|.:.:.|| |...:::.||::|.|.||.||:
Human   387 AKEIIQI-SGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACY 450

  Fly   578 YNNQQVALLLLEKGASPHATA---------KNGHTPLHIAARKNQMDIATTLLEYGALANAESKA 633
            :.:.::...||:.||..:..|         |:..|.|..|..|.. |...|||::......|   
Human   451 HGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGH-DAIVTLLKHYKRPQDE--- 511

  Fly   634 GFTPLHLSSQEG----HAEISNLLIEHKAAVNHPA-----KNGLTPMHLCAQEDNVNVAEIL 686
              .|.:..||.|    :..:.:.|.:.|:.....|     :.|| |.|...|...:...||:
Human   512 --LPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGL-PSHFHLQLSEIEFHEII 570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786
Ank_4 11..64 CDD:290365
ANK 38..163 CDD:238125
ANK repeat 43..74 CDD:293786
Ank_2 48..135 CDD:289560
ANK repeat 76..107 CDD:293786
ANK repeat 109..134 CDD:293786
Ank_4 110..163 CDD:290365
Ank_4 172..225 CDD:290365
ANK repeat 175..202 CDD:293786
ANK 199..324 CDD:238125 17/61 (28%)
ANK repeat 204..235 CDD:293786
Ank_2 209..300 CDD:289560 11/37 (30%)
ANK repeat 237..268 CDD:293786 1/4 (25%)
ANK 266..390 CDD:238125 42/124 (34%)
ANK repeat 270..300 CDD:293786 9/30 (30%)
ANK repeat 303..367 CDD:293786 22/63 (35%)
Ank_2 308..399 CDD:289560 33/90 (37%)
ANK 364..489 CDD:238125 37/126 (29%)
ANK repeat 369..400 CDD:293786 13/30 (43%)
ANK repeat 402..433 CDD:293786 8/30 (27%)
Ank_4 403..456 CDD:290365 8/52 (15%)
ANK repeat 435..466 CDD:293786 3/30 (10%)
Ank_2 440..530 CDD:289560 28/93 (30%)
ANK 463..588 CDD:238125 44/133 (33%)
ANK repeat 468..497 CDD:293786 14/28 (50%)
ANK repeat 501..530 CDD:293786 10/30 (33%)
Ank_2 506..597 CDD:289560 30/95 (32%)
ANK 529..654 CDD:238125 37/142 (26%)
ANK repeat 535..565 CDD:293786 8/34 (24%)
ANK repeat 567..598 CDD:293786 10/30 (33%)
Ank_2 572..661 CDD:289560 25/101 (25%)
ANK repeat 600..630 CDD:293786 8/29 (28%)
ANK repeat 633..662 CDD:293786 6/32 (19%)
ANK 661..785 CDD:238125 8/31 (26%)
ANK repeat 666..697 CDD:293786 7/21 (33%)
Ank_2 672..762 CDD:289560 4/15 (27%)
ANK repeat 699..730 CDD:293786
ANK repeat 732..762 CDD:293786
ZU5 927..1030 CDD:128514
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
FPGT-TNNI3KNP_001106279.3 ANK repeat 167..199 CDD:293786 9/31 (29%)
Ank_2 172..265 CDD:403870 30/92 (33%)
ANK repeat 201..232 CDD:293786 8/30 (27%)
PHA03095 221..>515 CDD:222980 101/333 (30%)
ANK repeat 235..265 CDD:293786 13/29 (45%)
ANK repeat 267..298 CDD:293786 13/30 (43%)
ANK repeat 300..333 CDD:293786 12/65 (18%)
ANK repeat 335..363 CDD:293786 13/27 (48%)
ANK repeat 370..403 CDD:293786 12/33 (36%)
ANK repeat 405..438 CDD:293786 8/32 (25%)
ANK repeat 440..470 CDD:293786 10/29 (34%)
PKc_TNNI3K 570..823 CDD:270966 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D53364at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

Return to query results.
Submit another query.