Protein Alignment Ank2 and ank2

DIOPT Version :10

• Sequence 1: NP_001189070.1
• Gene: Ank2 / 38863
• FlyBaseID: FBgn0261788
• Length: 13559
• Species: Drosophila melanogaster
• Sequence 2: XP_031758700.1
• Gene: ank2 / 100494806
• XenbaseID: XB-GENE-984843
• Length: 4583
• Species: Xenopus tropicalis
• Alignment Length: 5376
• Identity: 1632/5376 - (30%)
• Similarity: 2363/5376 - (43%)
• Gaps: 1478/5376 - (27%)

  Fly     3 TENGAQGDGNTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRG 67
            ||.....|.|.|||||||:|||::|:|:||..|||||||.|||||||||:|:|||.:|.||:.||
 Frog    39 TEQEVVSDSNASFLRAARSGNLDKVVEYLKGGIDINTSNQNGLNALHLAAKEGHIGLVQELMERG 103

  Fly    68 AIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSN 132
            :.||||||||||||||||||||.||||:|::..|::|.|||||||||||||||||..||:.||..
 Frog   104 SAVDSATKKGNTALHIASLAGQAEVVKILVKQGANINAQSQNGFTPLYMAAQENHIDVVKYLLET 168

  Fly   133 GANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHN 197
            |||||.||||||||||||:||||::|||:|||:||:||||||||||||:|||.|:|.|||.||||
 Frog   169 GANQSTATEDGFTPLAVALQQGHNQVVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHN 233

  Fly   198 PDVTSK--------SGFTPLHIASHYGNQNIANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMV 254
            .||.||        |||||||||:||||.|:|.||:.:||.|:::|::.|:|||||:|.|.||||
 Frog   234 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMV 298

  Fly   255 SLLLEKGGNIEAKTRDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDA 319
            .|||::||.|:||||||||||||||||||:|||::|||||||:.|:|||||:||||||||:||:.
 Frog   299 KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 363

  Fly   320 ARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLK 384
            .:.||.|:||||:||:||||:|||||||||.||.|||||:.|:.|||||||||||||||||||:|
 Frog   364 VKHLLQHKAPVDDVTLDYLTSLHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 428

  Fly   385 VVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLAARANQT 449
            |:|||:::||||.|.|||||||:|||||||.:|||:.|||:.|||||..:||||.||:||||.|.
 Frog   429 VMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 493

  Fly   450 DIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAAKEGQ 514
            :::|.||||||.|||||||:|||||||||||..:||.|||||.|..||.|.:.||.|||:|:|||
 Frog   494 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 558

  Fly   515 DEVAAVLIENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACHYN 579
            .:||:||:|.|||...||||||||||:.||||.:.||:||||:.|..||.||||:||||||.||:
 Frog   559 VDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAPPDAAGKNGLTPLHVAAHYD 623

  Fly   580 NQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANAESKAGFTPLHLSSQE 644
            ||:||||||:|||||..|||||:||||||::||||.||||||.|||..|..:..|.|||||::||
 Frog   624 NQKVALLLLDKGASPQVTAKNGYTPLHIASKKNQMQIATTLLNYGAETNILTNQGVTPLHLAAQE 688

  Fly   645 GHAEISNLLIEHKAAVNHPAKNGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASH 709
            |||::..||:..:|.::...||||||:||.||||.|.|.|||.|||||:|..||.||:||.||.|
 Frog   689 GHADMVTLLLNKQANIHVGTKNGLTPLHLAAQEDRVIVGEILSKNGANLDAQTKLGYSPLIVACH 753

  Fly   710 FGQANMVRFLLQNGANVDAATSIGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHIAR 774
            :|...||.|||.:||||:|.|..|||||||.|||||.||:|:||::.|..|..|.||.|.|.|||
 Frog   754 YGNIKMVNFLLNHGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQNGAKPNVTTSNGNTALAIAR 818

  Fly   775 KLGYISVLDSLKTITKEDETAAAPSQAEEKYRVVAPEAMHESF-MSDSEE-----EGGEDNMLSD 833
            :||||||:|:||.:|:|..|..  :...||:::..||.|.|.. :||.|:     :|||
 Frog   819 RLGYISVVDTLKVVTEEIVTTT--TTVTEKHKLNVPETMTEVLDVSDEEDDTMTGDGGE------ 875

  Fly   834 QPYRYLTVDEMKSLGDDSLP--------------IDVTRDERMDSNRMTQSAEYASGVPPT---- 880
                ||..:::|.|||||||              ::..|.:.:..:..:.|::.:..|..|
 Frog   876 ----YLRPEDLKELGDDSLPSSHYLDGMNYLRYSLEGGRSDSIMPSLRSFSSDRSHSVSHTSYLR 936

  Fly   881 ----IGEEVISPHKTQVY--GSSPKA--------TVDGVYIANG---SGHDEPPHVGRKLSWKSF 928
                |.:.:|.|::...|  .:.|..        .:|.:.:::.   ||| ..|.:.|..|  ||
 Frog   937 GSAMIDDSIIIPNEQVSYLAHAEPNTYRFSWGADNLDNIALSSSPIHSGH-MSPCLDRDNS--SF 998

  Fly   929 LVSFLVDARGGAMRGCRHSGVRMIIPSRSTCQPTRVTCRYVKPQR-------------------- 973
            ||||:|||||||||||||:|:|:|||||....|||||||.||..|
 Frog   999 LVSFMVDARGGAMRGCRHNGLRIIIPSRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEV 1063

  Fly   974 ---------TMH----PPQLMEGEALASRVLELGPCSTKFIGPVVMEVPHFASLRGKEREIIILR 1025
                     .:|    ||.|.|||:|.||:|:|||..|||:|||::|:||||:|||||||::|||
 Frog  1064 GPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVILR 1128

  Fly  1026 SDNGETWREHTIDNSEEIIHDVLQQCFEPEEIAQLEEQAGNHVCRFVTYDFPQYFAVVSRIRQEV 1090
            |::|:.|:||..:.:|:.::::|...  .|.:...|:.....:||.:|.|||||||||||::|:.
 Frog  1129 SESGDNWKEHFCEFTEDELNEILNGM--DEVLDSNEDLEKKRICRIITRDFPQYFAVVSRVKQDN 1191

  Fly  1091 HAIGPEGGMVSSTVVPQVQAVFPQGALTKKIKVGLQAQPVDPDLTAKLLGRGVAVSPIVTVEPRR 1155
            :.||||||::|||||||||||||:|||||:|:||||||||..:|..|:||.....|||||:||||
 Frog  1192 NLIGPEGGILSSTVVPQVQAVFPEGALTKRIRVGLQAQPVIVELVKKILGNKATFSPIVTLEPRR 1256

  Fly  1156 RKFHKAITLSMPAPKAHSQGMINQYSGNTPTLRLLCSITGGPSRAQWEDVTGSTPLTFVNDCVSF 1220
            |||||.||:::|.|||.|:.|:|.|.|.|||||||||||||.:.|||||:||:|||||||:||||
 Frog  1257 RKFHKPITMTIPVPKASSEAMLNGYGGETPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSF 1321

  Fly  1221 TTTVSARFWLMDCRNISDATKMATELYKEVIHVPFIAKFVVFAKKVEPFEAKLRVFCMTDDREDK 1285
            ||.|||||||:|||.|.::...|.::|:|:|.||::||||||||..:|.||:||.||||||:.||
 Frog  1322 TTNVSARFWLIDCRQIQESVTFAGQVYREIICVPYMAKFVVFAKSQDPIEARLRCFCMTDDKVDK 1386

  Fly  1286 TLEKHELYTEVAKSRDVEVLEGKPQYIEMAGNLVPVTKSGDQLQVQFKAFRENRLPFTVRVKDQH 1350
            |||:.|.:.|||:|||||||||||.|::..|||||:||||......|.||:|||||..|:|:|..
 Frog  1387 TLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFYAFKENRLPLFVKVRDTT 1451

  Fly  1351 ADIVGRTLFMKEPKVAKGEPPQQPICILNIVLP--------------EAVIPDSTTAFSDRVTSA 1401
            .:..||..||||||..:| ...|.||.|||.||              |..|   |:..:|..|.:
 Frog  1452 QEPCGRLSFMKEPKSTRG-LVYQAICNLNITLPLYNKESESDQEPEDEGTI---TSDKNDEETES 1512

  Fly  1402 YRTSMFSLSKHQNDHYIGDIRIVDLSNLLGKDWIQLAPEIGINGEEIDEIINQNTDSIARQAQSM 1466
            ..||:.      ..|.:.|:.::...:||.:                          :....|.:
 Frog  1513 TETSIL------KSHLVNDVPVLASPDLLSE--------------------------VCEMKQDL 1545

  Fly  1467 IRLYKDKPNYDILSLETALKNIGRDDIMKKCKSGRLSHSREFDEADLMKNSESVEELVRRESKRI 1531
            |::..      ||:.::|.            |:|.|. :::.|:.|  ::.....|:|.:..:.:
 Frog  1546 IKMTA------ILTTDSAQ------------KAGSLK-AKDIDKGD--EDPGEPFEIVEKVKEDL 1589

  Fly  1532 QQINE-REEVKYSAEEKEVEESE-------------SDEEAAKRTVAERREKIVKRLSIERSIPA 1582
            :::|: .....|:.||...|.::             ||||.       :..|:...|.:| .||.
 Frog  1590 EKVNKILRTGTYAKEESFTEGAQALWPYKKEEWVILSDEEV-------QEAKLNAHLEVE-EIPC 1646

  Fly  1583 STQKKEITR-EITEIKRKSLIEDKKAHHESEILMQLPADNVIIKTTTVPDQVIKMKMGKMDSTEV 1646
            .  :..|.| |.|:||.          :.:||:..|..|    ....:|||.:.: ..:|...|.
 Frog  1647 I--EVRIDRGEKTKIKT----------NNTEIVNYLTDD----LNAYIPDQEVTL-TSQMQRKEQ 1694

  Fly  1647 SK--SEFDKELTHKFKTSGRSSEEEDQPSYPDQTDKIVQDISAAEKKEKDGVTFSRVTTITRQEA 1709
            .|  .|..|.:..|.:.  |..|||.|.         :...|:.|  ..||......|.:|  :|
 Frog  1695 RKIPLEIKKPIRRKLRE--RQKEEERQG---------LTKFSSEE--SLDGEICPLATAVT--DA 1744

  Fly  1710 RDITEDFLEIEKRSQLPATSTTATVHEKFVEEIKEKTSPLASVPQETVKEVQQVISEVTEIASKK 1774
            :|:                  :.:|.|..:..||:|...|    |:.|:|.|:|:.:...:.:..
 Frog  1745 KDV------------------SPSVEETPIGSIKDKVKVL----QKQVEEEQKVLKDEIGLIATA 1787

  Fly  1775 VENIISSFESSKSVDATTVLPTQPSVESTKVSETIKNL-----EDAKAVSAE---QVKTVHVVES 1831
            :            |||..:.|.........:.:.:|.|     |:.||:..:   .|..|....|
 Frog  1788 I------------VDAKKISPVIEETPIGSIKDKVKALQKQVDEEQKALDGKIGLNVSAVTEKVS 1840

  Fly  1832 SSIEETIAEFEAKKVKYDFHGGEPKTQIPKFTRKPSDDSMKPTAAPR--ATVES-----ETESVL 1889
            |.||||..             |..|.::..|.|:.  ||.:.|.:.:  .||.:     :...|:
 Frog  1841 SVIEETPI-------------GSIKDKVKAFQRQA--DSEQKTFSDKLDLTVTAIAGAPDISPVI 1890

  Fly  1890 ETKAEKPISKI--PVKTIP---TEAQKVSEVDARKITQDFLQGEKLAAEPKPSPAASKIPKVEPR 1949
            |   |.||..|  .|||:.   .|.|:|.:.:...........|:::...:.:|..|...:|:
 Frog  1891 E---ETPIGSIKEKVKTLQKQVEEEQRVLDYEIGPTATPVADDEEISHVIERTPIRSIKDEVQ-- 1950

  Fly  1950 KSVDKQVDRESKIL-DDVVASTATIMTAGLGDEQLKDQLVDHSEIIAKSETVAEKVTELLD--TF 2011
             ::..|||...|.| ||....|.|::|.                        |:||:.:::  ..
 Frog  1951 -ALQTQVDEGPKALDDDETGLTTTVITG------------------------AKKVSPVVEETPI 1990

  Fly  2012 HKIEEKVTKSEKTSEISSKVEELVKIEEKPLSQVQPKE---DKVAEKVAEV----IETFHKIEEK 2069
            ..|::||...:|..|     ||......|| |:||.|:   :.|.|:..::    |.:..|.|..
 Frog  1991 GSIKDKVKALQKRVE-----EEQHPPSSKP-SKVQIKQASFESVTEQKVQIGKPPISSSAKTERL 2049

  Fly  2070 ITTADARELTRDFLSMEQQNQLPSMPQAA---EKPLESSLTSTSASEPESIVT------------ 2119
            ..|...|:|.:.|    |....||..::.   .|.::|::....:.:.|.:.|
 Frog  2050 EETMSVRDLMKAF----QSGHDPSKERSGLFEHKTVKSTIKLCESEQGEVLKTYTFQDSEDLCIV 2110

  Fly  2120 -----VKPSPPASKIPVVEPRKIVFDESTKPLIEPEPVKTTEKKPLNERQLTADFLSMEQQTQLV 2179
                 |:.|...:::...|..|::..|:|.  :|.|...|.|:..:.|:       :.|.:...:
 Frog  2111 KDGIQVEYSETETELRHHEKEKLMLTETTG--LEAELGMTKEEFHITEK-------TSEHRVCEL 2166

  Fly  2180 SEPAKSL-----------------------VEEVMKSAEQMVEQPKQQKSLNERQLTEDFLLMEQ 2221
            |:|..||                       :....|::....|..|::...|:|.|....|...:
 Frog  2167 SKPICSLYNGESTKHSKVRTSSSDQDVDPQISPDRKTSTDFSEVIKEELEDNDRYLQFKLLTESE 2231

  Fly  2222 QTQL--------PSDIVKPTDKLIDGIESAAPVGDEASPFHTPKLTTSVVTQEPQQLASEYDSDT 2278
            ..||        |.:|..|:|...:|              :.|.|              ...|.|
 Frog  2232 GAQLNLDQVLISPFNITFPSDYETEG--------------YLPGL--------------HLQSGT 2268

  Fly  2279 FGKQATIPLGDSKIDQGLI-APVSM---EPRKSLTDAEFCKSVGETITKKMSVGVIEISDELKKI 2339
            |...:     ||...:|:. :|.|:   .|:.|..|:...:.:.||
 Frog  2269 FDDSS-----DSLKHEGVADSPGSLLDGTPQMSSEDSLKHEGLAET------------------- 2309

  Fly  2340 ESEIPHSQTPPPTPSDNKTDKQNEEP-----------------------ELISLERDYLADTVTT 2381
            ....|.|.:.||..||.:||:..:.|                       :.:..||:.|.:....
 Frog  2310 PGTSPDSLSCPPKKSDKQTDEGLKTPSNIVSKPSSTFVDHDQLLTQAHIDSVESEREILENVSED 2374

  Fly  2382 LHTTTESTLERV----SAITK-----IEHFSVHNVKSE--------------TFTRTDEPDKLLH 2423
            ..|...||::.:    |.:|:     ||...::..|:|              ..|:.:||    :
 Frog  2375 GQTEMSSTMKNICTEQSFVTEKLAGCIEVTEINEDKNEHSVSVKGHQGLELVLSTQNEEP----N 2435

  Fly  2424 SVVAPPDIQKLY--SQDTTSFTEMSTSSQT-----PKMTTTTTMTAQIDRTKVDLTIPGQDQQKQ 2481
            |.||...|...:  |.:::...|.::|.:|     |..|..:.....::.:.|:.||      |.
 Frog  2436 SPVADESIAISHKDSLESSPVVEDNSSHKTPDSLEPSPTKESPCCDSLESSPVEHTI------KF 2494

  Fly  2482 KDLKEQSAVVVDAKAE--TEKTASDREYLEQIMGCGDVRRKIMR-------LESSCSTESLESVG 2537
            ..|...:|:....|.:  ||.|:              :|.:|:|       .:|...|..:||.|
 Frog  2495 GILLNSAAIYTSLKPDLNTEVTS--------------LRSRILRDPDGSAEDDSVEQTSLMESSG 2545

  Fly  2538 KS--STVTPKYIGDNVPVVREVVQSMEDKICSTVV---SAIPFTVQKRKPHDDDKEPNIVELEKQ 2597
            ||  |..||    .:..:..||....:|....:::   ..|| .|.:....|.::||      |:
 Frog  2546 KSPLSPDTP----SSEEISYEVTPKSQDLQAFSMLPKPGTIP-EVAEEPEEDSEREP------KR 2599

  Fly  2598 ILTPADLALEKIFKCEPPSEVVKISPIEAMSLGLKEIDEEVCEK-VCEKRKSFVVAEDLCETEKT 2661
            ..||.    |::||.     |.||...:       |:::|..:| .|:|..    ..|.| |...
 Frog  2600 RFTPE----EEMFKM-----VTKIKMFD-------ELEQEAKQKRECKKES----RHDEC-TSSD 2643

  Fly  2662 LTEQVIDLNRQVDQVPARVFTETIERHLDLEDRDVIEALPKVREVVQDIERKYPAASLEAKPFSP 2726
            |:....|                     |||..|:        ::|||.:.:....::|::..|.
 Frog  2644 LSNSNGD---------------------DLEGADI--------KLVQDNDVQIVVMAVESRKSSS 2679

  Fly  2727 RKRVTPDRKVDVSSLEQQILTDADLILDGL-----------GSKCVPEQKVQSPIF---SSNKAS 2777
            .....|    :::.|::.  .|:.|::|.:           .|...||.....||.   .|.||.
 Frog  2680 SSESEP----ELTQLKKG--ADSGLLMDPVIRVQPPSPYAPSSSSSPEDTAFQPIAIAQDSFKAE 2738

  Fly  2778 SSTENLEDICEKKCSKRTISDMTKVFERQEDPTTMPSIKDVKSTTAKFLESESGKFAITESIQHF 2842
            .|.:|.....::|.......|... |..::..|.:|...|:          |.|:....|..:..
 Frog  2739 DSQQNYVSTIDRKLEDVNTHDSLH-FSNEDVTTIIPCSADI----------EVGQMEGAEKSEPV 2792

  Fly  2843 NAKGSINKEVAGIEKGQIRFLKDCDTQEFPIETNLDTKLVEFPKITHTLER----LHSISKTDIA 2903
            ::||...|.:|     ...:|.:        |...:.|:...|...|..|.    ::|.|.|.
 Frog  2793 SSKGPAEKSIA-----YTTYLTE--------EKRPEEKIQTLPHDFHHSESPEGDVYSDSSTQ-- 2842

  Fly  2904 DTKKVVHESSEFKSKLDKLVHKTEQTDNQNPDKFKFPTQDNFDELQTQKSLTSELVTMTDSSEYK 2968
            |:..||    :.|...|.::   ||.|            :|......:||.||.||..:..|...
 Frog  2843 DSFSVV----KGKQTYDDMI---EQKD------------ENLHFSSEKKSETSRLVLRSTGSATD 2888

  Fly  2969 FPPEGKS---ILGKEPI---------------ESESDEELDNL---NKICKLQLLSKIEQSS-FI 3011
            ...|.||   |:|.|.|               .||||:.::|:   :..|:......|..|: .|
 Frog  2889 LTDEKKSYEEIVGLECIPSSDFIFSNAQDGSHHSESDDNVENIPINDGSCQSAQDRSISVSADEI 2953

  Fly  3012 DTTEIANTEKREITKFPTTNDSHSDLFSKSRATLKTQSGEKTHCTHFTETISDKNYNSFSDTSFL 3076
            |..::.:.::.|:.........|  :|:.|..|    .||:......|:.:|..::...|:.:..
 Frog  2954 DDVQMESADESELESPNAPGTQH--IFNTSCFT----DGERRQENVVTDVLSVFHHTESSEENVG 3012

  Fly  3077 LNSVTASADKSPLHPEEKTKSPEKKDEKVLAQPDDNFKS---------VIETDKPSPKEYSDEIE 3132
            |..|..:.:.||               .:|    |:|||         .:|.|      .:..::
 Frog  3013 LECVPLAENISP---------------SLL----DSFKSEECQLKCADTLEND------LNKHMD 3052

  Fly  3133 IPKPLDKPIS-HPTSLVTGVTFGGDKSPLHPEEKPKSPVKIDEEVLAKPGGSSKSVVETDKPSPK 3196
            |....|..|| |....|  :...|:.||::         |:.|.|       :.:.:..|....:
 Frog  3053 IELSCDGNISAHEIDDV--LMESGEDSPVN---------KVAESV-------AYTFLTDDNEITE 3099

  Fly  3197 EYSDDETEDEIDFPKPQDKPFKEATPS-------VTPVSTIPDVKAIDFVSFKAEECSTTIQTNI 3254
            :|:|....|           |....||       ..|.:.:....|.||  :|.||...|....:
 Frog  3100 KYADTILHD-----------FHHRGPSKEDIGLECRPPADLISPNAQDF--YKGEESEQTFYGTL 3151

  Fly  3255 KLASTSLTTKDT-KIVQPIDSLSNLKDDKFPTSVGDKAKSPRESVKPNLKEYSDKEEKPDSHPVS 3318
            :   |.....|. .|....|.|:.:           :.:||.|.|          .:.||:..:.
 Frog  3152 E---TEQEDWDIFSIPANADELNEM-----------QTESPHEGV----------SKSPDALILK 3192

  Fly  3319 LVTSVTGSGDKSPLHPEEKPKSPEKKDEKILAKPDDSSKSVVKTDKPSPKEYSDDEIEDEIEIPK 3383
            ...|||        |..|    .|:..:|:.|.|.|...|              |.:||.|..
 Frog  3193 NNVSVT--------HLTE----CEETVKKVEAIPHDLCHS--------------DILEDHIAY-- 3229

  Fly  3384 PLDKPISHPTSLVTSVTGSGDKSPLHPEEKPKSPEKKDEKVLAK--PDDSSKSVVKTDKPSPKEY 3446
                ||.|...              ..:||.|..:|.:::.:.|  |.|...|.         .|
 Frog  3230 ----PIVHEAE--------------ESQEKCKGTKKIEQEDIKKHFPSDEITST---------PY 3267

  Fly  3447 SDDETEDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPE-----------EKLKSPEKKDEKV 3500
            :.||..|::::....:..|..        |:|...|....|           |.:     .|:.:
 Frog  3268 TVDEIHDDVQMESAHESVIES--------TYGSVMSSNSVEIIQEHYTTMCLEHI-----PDDYI 3319

  Fly  3501 LAKPDDS------SKSVVKTDKPSPKEYSDDET-----EDEIEIPKPLDKPISHPTSLVTGVTFG 3554
            ..|..||      ....::||:.|...:....|     |:.|.    ||......||..
 Frog  3320 TQKTQDSYVISPVKSDCIETDRTSDTVFCTSPTFFQNVENNIS----LDSAAEVETSTC------ 3374

  Fly  3555 GDKSPLHPEEKLKSP----------EKKDEKVLAKPDDSSKSVVKTDKPSPKEYSDDETEDEIEI 3609
             |.:.:.|.|.:.|.          |.::::.::....:::..|...:.:...:.:|.|::|.:.
 Frog  3375 -DPAVISPYENVPSGHFFTSQDILLETEEKQNISATFINAEEKVPITQTNSDIFGEDLTQEESDT 3438

  Fly  3610 -----------------PKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKPKSPEKKDEKVLAKPD 3657
                             ....::.:..||:.::..|               |.::.::.::.:||
 Frog  3439 CSADHLHSSTKHTSWCSSASSEEEVCCPTAELSSNT---------------SDDQFNKVIITRPD 3488

  Fly  3658 GSSK--SVVKTDKPSPKEYSDDET------EDEIEI-----------PKPLDKPISHPTSLVTGV 3703
            ..|.  |.::         .|||.      |:|.:|           ..|...|...||.
 Frog  3489 ADSDTWSCIR---------EDDEAFEARVKEEEQKIFGLIADKQSQGTTPDTTPARSPTE----- 3539

  Fly  3704 TFGGDGSPLHREEKP--KSPEKKDEKVLAKPDDSSKSVVKTDKPSPKEYSDD------------- 3753
                ||:|.: |:.|  ....|..|...:...|.:|          :.|:|:
 Frog  3540 ----DGTPTN-EQNPFLFQEGKLFEMTRSGAIDMTK----------RNYADESFHFFQIGEHCGQ 3589

  Fly  3754 --------ETEDEIEIPKPLDKPISHPTSLVTGVTYGGDGSPLHPEEKPK--------SPEKKDE 3802
                    |...|.|...|.|.|....|.....||           |:|:        :....|:
 Frog  3590 EAIIEEIKEESGEEESVNPDDFPDLLATEDFDNVT-----------EEPQDTCETLYDTDLNSDD 3643

  Fly  3803 KVLAKSDDSSKSVVKTDKPSPKEYSDDETEDEIEIP------------KPLDKPISHPTSLVTGV 3855
            ..||..||:.:...:||:.|             .||            ||....|......:|..
 Frog  3644 LCLASVDDNDREETRTDQKS-------------RIPIKMGIAASSAPSKPFASEIPLSEEQLTSS 3695

  Fly  3856 TFGGDGSPLHPE------------------EKPKSPEKKDEKVLAKPDGSSKSVVETDKPSPKEY 3902
            :. .|.||..||                  |:..||:...|:        .||::|......:..
 Frog  3696 SL-QDSSPSPPECVVNLQNNFIPFAKLECAERGDSPDSSPEE--------QKSIIEIPTAIMECG 3751

  Fly  3903 SDDETEDEIEIPKPLDKPISHPTSLVTGVTFGGDGSPLHPEEKPKSPEKKDEKVLAKPDDSSKSV 3967
            |....:.:|.:....::| ||..|:.:..|...|......::|||                ||..
 Frog  3752 SSASIKSKIPVRAVSEEP-SHTFSIGSESTCPADDHIYLEDQKPK----------------SKIP 3799

  Fly  3968 VKTDKPSPKEYSDDETEDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKLKSPEKKDEKV 4032
            |||..|..:::.                ||:             |.|....|:..|.|.|:|..
 Frog  3800 VKTSLPKAEQHF----------------PIT-------------DTSLKMSEDNSKLPLKQDRS- 3834

  Fly  4033 LAKPDDSSKSV-VKTDKPSPKEYSDDETEDEIEIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEE 4096
             ....||..|| :|| :.|.|..|..||..|                       ..:||....||
 Frog  3835 -KSESDSCSSVDIKT-RRSVKTKSCTETFYE-----------------------STEKSTCFFEE 3874

  Fly  4097 ------KPKSPEKKDEKVLAKPDGSSKSVVETDKPSPKEYSDDETEDEIEIPKPLDKPISHPTSL 4155
                  ||||   ...::..|....|.|.::|..      :.|:.|...||.|
 Frog  3875 ETSEATKPKS---YSSRLPVKAKNKSASQIKTST------TTDDQEQFFEIYK------------ 3918

  Fly  4156 VTGVTFGGDGSPLHPEEKPKSPEKKDEKVLAKPDDSSKSVVK-TDKPSPKE-YSDDETED-EI-- 4215
             ..:.|..:.|                      |::||.|.: |...|.:| .||||:.. ||
 Frog  3919 -NSIDFFEEIS----------------------DEASKLVDRLTQAESEQEPVSDDESSAFEISV 3960

  Fly  4216 --EIPKPLDKPISHPTSLVTGVTFGGDGSPLHPEEKPKSPEKKDEKVLAKPDDSSKSVVKTDKPS 4278
              .:|.| |...|.|..:.       |..|:..|    |.|.:.|::   |||.|....:.|
 Frog  3961 IENVPAP-DFQQSVPEDIF-------DTRPIWDE----SVETQIERI---PDDHSHDNFQVD--- 4007

  Fly  4279 PKEYSDDETEDEI------------EIPKPLDKPISHPTSLVTGVTFGGDKSPLHPEEKPKSPEK 4331
              ...||.||:.:            |:.|.||              |..::......|.|.|.:.
 Frog  4008 --FREDDRTEERLAHIADHLGFSWTELAKELD--------------FTEEQIQQIRVENPNSLQD 4056

  Fly  4332 KDEKVL---AKPDGSSKS------------------VVETDKPSP------KEYSDDE---TEDE 4366
            :...:|   .:.||...:                  ::||....|      :.|:|.|   |.|.
 Frog  4057 QSHALLKYWLERDGKHATDISLNQCLTKINRMDIVHLMETSIQEPPGGRANRTYADIEQSLTMDR 4121

  Fly  4367 IEIPKPLDKPISHPTSLVTGVTFGGDGSPL--HPEEKPKSPEKKDEKV---------LAKPGGSS 4420
            .|....:......|...:|.......||.:  ||      |...:|.:         .:......
 Frog  4122 SEGFSAIQDEFGSPQKRITADYTASPGSEIAGHP------PLVSEEDISISYSSFHESSSKAEDD 4180

  Fly  4421 KSVVETDKPSPKEYSD-DETEDEIEIPKPLDKPISHPTSLVTGVTFGVDKSPLHPEEKPNSPEKK 4484
            |||||..:...||..: |.|.::.|:...|                              |||::
 Frog  4181 KSVVEMLRQLQKEKVEADLTREQQELSGAL------------------------------SPEQQ 4215

  Fly  4485 DEKVLAKPDDSSKSVVKTDKPIPKEYSDDETEDEIEIPKPLDKPISHPTSLVTGVTFGGDGSPLH 4549
            :....:.|.::..|.|:..:.:.:.......::..|:.| ||:|     .|.|.|:.....||:
 Frog  4216 EYFDTSPPVETVSSPVEAQEFMSRTQVSQSPQETPELEK-LDRP-----DLYTPVSDQHSESPV- 4273

  Fly  4550 PEEKPKSPEKKD------EKVLAKPDDSS---------KSVVKTDKPSPKEYSDDET---EDEIE 4596
            .:|..:|.|:.|      :..:|:..|..         :|:...:|...:|..:.||   |||:.
 Frog  4274 VQEPSESSEQGDLYASGSDLFIAESSDEQHDKNKRTEFRSLESFEKELAEELGELETTSDEDEMV 4338

  Fly  4597 IPKPLDKPISHPTSLVTGVTFGGDGSPLHPE---EKPKSPE-------KKDEKVLAK---PDGSS 4648
            ..:.:.:.:         :....|...:.||   |:..:.|       |...|::.:   |||:.
 Frog  4339 TTRVVRRRV---------IIQADDMPDILPETVTEEQYTDEHGHIVVKKVTRKIIRRYVLPDGTE 4394

  Fly  4649 KS--VVETDKPSPKEYSD---------------DETEDEIEIPKP----------------LDKP 4680
            |.  ||:..|..|....:               |..:.||...:|                :.|.
 Frog  4395 KEEVVVQGGKQDPVTIEEGDSFSKVLKRTVVKSDTEQSEIAFSEPRVLTSEFEAEQVEGRKVSKV 4459

  Fly  4681 ISHPTSLVTG---VTFGGDGSPLHPEEKPKSPEKKD---------------------EKVLAKPD 4721
            |.  |::|.|   ..:.||     |......|..||                     ||.:.|.|
 Frog  4460 IK--TTMVHGERMEKYVGD-----PSLASDLPSAKDDFEQALSYVGGDVKCNLPTLEEKEIIKED 4517

  Fly  4722 GS------------SKSVVETDKPSPKEYSDDETEDEIEIPKPLDK 4755
            ||            .|..|..|:.. |....::.||   :|:.|.|
 Frog  4518 GSVIKRTMMNKARTQKRTVVKDQHG-KHVFVEQLED---VPEVLPK 4559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANKYR	10..308	CDD:440430	219/305 (72%)
		ANK repeat	10..41	CDD:293786	21/30 (70%)
		ANK repeat	43..74	CDD:293786	21/30 (70%)
		ANK repeat	76..107	CDD:293786	21/30 (70%)
		ANK repeat	109..134	CDD:293786	18/24 (75%)
		ANK repeat	175..202	CDD:293786	20/26 (77%)
		ANKYR	190..473	CDD:440430	205/290 (71%)
		ANK repeat	204..235	CDD:293786	20/30 (67%)
		ANK repeat	237..268	CDD:293786	19/30 (63%)
		ANK repeat	270..300	CDD:293786	24/29 (83%)
		ANK repeat	303..367	CDD:293786	45/63 (71%)
		ANK repeat	369..400	CDD:293786	24/30 (80%)
		ANKYR	383..671	CDD:440430	191/287 (67%)
		ANK repeat	402..433	CDD:293786	23/30 (77%)
		ANK repeat	435..466	CDD:293786	21/30 (70%)
		ANK repeat	468..497	CDD:293786	20/28 (71%)
		ANK repeat	501..530	CDD:293786	17/28 (61%)
		ANK repeat	535..565	CDD:293786	19/29 (66%)
		ANK repeat	567..598	CDD:293786	23/30 (77%)
		PHA03100	599..>773	CDD:476869	105/173 (61%)
		ANK repeat	600..630	CDD:293786	22/29 (76%)
		ANK repeat	633..662	CDD:293786	14/28 (50%)
		ANK repeat	666..697	CDD:293786	22/30 (73%)
		ANK repeat	699..730	CDD:293786	18/30 (60%)
		ANK repeat	732..762	CDD:293786	19/29 (66%)
		ZU5	930..1027	CDD:459941	68/129 (53%)
		UPA_2	1253..1384	CDD:375346	79/144 (55%)
		Death_ank	1417..1497	CDD:260029	8/79 (10%)
		PTZ00121	<1443..2235	CDD:173412	181/889 (20%)
		PTZ00449	<3292..3611	CDD:185628	65/369 (18%)
		PTZ00449	<4400..4857	CDD:185628	88/466 (19%)
		PTZ00449	<4908..5267	CDD:185628
		PTZ00108	<5179..5374	CDD:240271
		PTZ00108	<6034..6230	CDD:240271
		PTZ00449	<6620..6979	CDD:185628
		PTZ00108	<7119..7314	CDD:240271
		PTZ00108	<7347..7544	CDD:240271
		PTZ00108	<7651..7848	CDD:240271
		PTZ00449	<7804..8119	CDD:185628
		PTZ00108	<8183..8381	CDD:240271
		PTZ00449	<8430..8745	CDD:185628
		PTZ00449	<8784..9125	CDD:185628
		PTZ00449	<9028..9353	CDD:185628
		PHA03307	9225..>9575	CDD:223039
		PHA03307	9903..>10259	CDD:223039
		PTZ00108	<10177..10451	CDD:240271
ank2	XP_031758700.1	ANKYR	60..418	CDD:440430	257/357 (72%)
		ANK repeat	79..110	CDD:293786	21/30 (70%)
		ANK repeat	112..143	CDD:293786	21/30 (70%)
		ANK repeat	145..170	CDD:293786	18/24 (75%)
		Ank_4	148..199	CDD:372654	39/50 (78%)
		Ank_4	208..269	CDD:372654	41/60 (68%)
		ANK repeat	211..246	CDD:293786	22/34 (65%)
		ANK repeat	248..279	CDD:293786	20/30 (67%)
		ANK repeat	281..312	CDD:293786	19/30 (63%)
		ANK repeat	314..344	CDD:293786	24/29 (83%)
		ANKYR	328..616	CDD:440430	202/287 (70%)
		ANK repeat	347..378	CDD:293786	20/30 (67%)
		ANK repeat	380..410	CDD:293786	22/29 (76%)
		ANK repeat	413..444	CDD:293786	24/30 (80%)
		ANK repeat	446..477	CDD:293786	23/30 (77%)
		ANK repeat	479..510	CDD:293786	21/30 (70%)
		ANK repeat	512..541	CDD:293786	20/28 (71%)
		ANK repeat	545..570	CDD:293786	14/24 (58%)
		ANKYR	565..830	CDD:440430	170/264 (64%)
		ANK repeat	578..607	CDD:293786	18/28 (64%)
		ANK repeat	611..644	CDD:293786	25/32 (78%)
		ANK repeat	645..675	CDD:293786	21/29 (72%)
		ANK repeat	677..706	CDD:293786	14/28 (50%)
		ANK repeat	710..741	CDD:293786	22/30 (73%)
		ANK repeat	743..774	CDD:293786	18/30 (60%)
		ANK repeat	776..805	CDD:293786	18/28 (64%)
		ZU5	996..1133	CDD:128514	73/138 (53%)
		UPA_2	1354..1483	CDD:375346	77/129 (60%)
		PLN03229	<1711..1912	CDD:178768	59/267 (22%)
		Death_ank2	4012..4095	CDD:260066	14/96 (15%)