DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ank2 and ANKRD61

DIOPT Version :9

Sequence 1:NP_001189070.1 Gene:Ank2 / 38863 FlyBaseID:FBgn0261788 Length:13559 Species:Drosophila melanogaster
Sequence 2:NP_001258629.1 Gene:ANKRD61 / 100310846 HGNCID:22467 Length:418 Species:Homo sapiens


Alignment Length:434 Identity:114/434 - (26%)
Similarity:189/434 - (43%) Gaps:81/434 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   262 GNIEAKTRDGLTPLHCAARSGHEQVVDML--LERGAPISAKTKNGLAPLHMAAQGEHVDAARILL 324
            |||   ||.|          ..:.|||..  ||.|...:..:|     |:.|...|......:||
Human     2 GNI---TRKG----------SRDLVVDSAKSLEDGPSAALHSK-----LYEAIMREDCTTIEVLL 48

  Fly   325 YHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVELL 389
            .:. ||::.    :|.|..:|.      .:|||.:..::       ..|:|:|.|.::.:.:..|
Human    49 RNH-PVNQP----ITILPNSAS------NRLLLTQPTES-------IIPIHLAAKYHKAQSLLCL 95

  Fly   390 LRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQH-------DASPDVPTVRGETPLHLAARAN 447
            |||||.......:|||.|::            :|.|       .|.|...|.|..|.:    :.:
Human    96 LRHGADPEVRDTTGLTTLNL------------MLLHWPVTSTTWAKPGNRTHRILTDI----QNS 144

  Fly   448 QTDIIRILLRNGAQVDARAR--EQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKDMYTALHIAA 510
            ....:|||..:||||:.:..  .:::|||:|...|...::.:|.|:||.|:|..:...|.||:||
Human   145 SITCLRILCAHGAQVNTQGEISNKRSPLHLAIAYGCYPVLSILTQNGADVNAINEASMTPLHMAA 209

  Fly   511 KEGQDEVAAVLIENGAALD-AATKKGFTPLHL-----TAKYGH-----IKVAQLLLQKEADVDAQ 564
            .....|:...||..||.:: |.:..|.|||.|     ::|.|.     :...:|||...|.|:||
Human   210 NMLNKEMMETLIAYGANVNCAVSSTGNTPLKLAVCTASSKAGRLLGAGVSCIRLLLTHGAKVNAQ 274

  Fly   565 GKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEYGALANA 629
            ...|.|.:|.||....:.:..||||..|:.:...:||.:|:::..::: .::..|.|....|.:.
Human   275 DYKGQTAIHEACFGGREAIINLLLEFEANVNILTRNGESPIYMYLQRS-CNVRDTALLARLLYHT 338

  Fly   630 ESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGLTPMHL 673
                  .||.:::.:|......:|.|.:...:...|....|:.|
Human   339 ------YPLRMTNNQGILPAGIMLPEFRLLRDTLIKQSQKPLSL 376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ank2NP_001189070.1 ANK repeat 10..41 CDD:293786
Ank_4 11..64 CDD:290365
ANK 38..163 CDD:238125
ANK repeat 43..74 CDD:293786
Ank_2 48..135 CDD:289560
ANK repeat 76..107 CDD:293786
ANK repeat 109..134 CDD:293786
Ank_4 110..163 CDD:290365
Ank_4 172..225 CDD:290365
ANK repeat 175..202 CDD:293786
ANK 199..324 CDD:238125 16/63 (25%)
ANK repeat 204..235 CDD:293786
Ank_2 209..300 CDD:289560 12/39 (31%)
ANK repeat 237..268 CDD:293786 3/5 (60%)
ANK 266..390 CDD:238125 27/125 (22%)
ANK repeat 270..300 CDD:293786 7/31 (23%)
ANK repeat 303..367 CDD:293786 13/63 (21%)
Ank_2 308..399 CDD:289560 23/90 (26%)
ANK 364..489 CDD:238125 33/133 (25%)
ANK repeat 369..400 CDD:293786 10/30 (33%)
ANK repeat 402..433 CDD:293786 8/37 (22%)
Ank_4 403..456 CDD:290365 13/59 (22%)
ANK repeat 435..466 CDD:293786 9/30 (30%)
Ank_2 440..530 CDD:289560 28/92 (30%)
ANK 463..588 CDD:238125 42/137 (31%)
ANK repeat 468..497 CDD:293786 10/28 (36%)
ANK repeat 501..530 CDD:293786 10/29 (34%)
Ank_2 506..597 CDD:289560 34/101 (34%)
ANK 529..654 CDD:238125 34/135 (25%)
ANK repeat 535..565 CDD:293786 13/39 (33%)
ANK repeat 567..598 CDD:293786 10/30 (33%)
Ank_2 572..661 CDD:289560 19/88 (22%)
ANK repeat 600..630 CDD:293786 6/29 (21%)
ANK repeat 633..662 CDD:293786 5/28 (18%)
ANK 661..785 CDD:238125 3/13 (23%)
ANK repeat 666..697 CDD:293786 2/8 (25%)
Ank_2 672..762 CDD:289560 1/2 (50%)
ANK repeat 699..730 CDD:293786
ANK repeat 732..762 CDD:293786
ZU5 927..1030 CDD:128514
Death_ank 1417..1497 CDD:260029
ER-remodelling 11936..>12013 CDD:258892
ANKRD61NP_001258629.1 ANK 1 27..57 8/39 (21%)
ANK <32..115 CDD:295348 27/100 (27%)
ANK 2 75..104 10/35 (29%)
ANK 79..221 CDD:238125 45/157 (29%)
ANK repeat 79..106 CDD:293786 10/26 (38%)
Ank_2 80..198 CDD:289560 38/133 (29%)
ANK repeat 108..163 CDD:293786 18/70 (26%)
ANK 3 132..161 10/32 (31%)
ANK 166..298 CDD:238125 42/131 (32%)
ANK 4 167..196 10/28 (36%)
ANK repeat 169..198 CDD:293786 11/28 (39%)
Ank_2 172..275 CDD:289560 34/102 (33%)
ANK repeat 200..232 CDD:293786 11/31 (35%)
ANK 5 200..229 10/28 (36%)
ANK repeat 234..275 CDD:293786 13/40 (33%)
ANK 6 234..273 12/38 (32%)
Ank_5 263..317 CDD:290568 20/53 (38%)
ANK 272..>351 CDD:238125 21/85 (25%)
ANK repeat 277..308 CDD:293786 10/30 (33%)
ANK 7 277..306 10/28 (36%)
ANK 8 310..343 8/39 (21%)
ANK repeat 319..345 CDD:293786 5/32 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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