DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ank2 and ankef1b

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	XP_021322982.1	Gene:	ankef1b / 100149106	ZFINID:	ZDB-GENE-060810-68	Length:	530	Species:	Danio rerio

Alignment Length:	500	Identity:	117/500 - (23%)
Similarity:	189/500 - (37%)	Gaps:	97/500 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 NALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNG 110
            :||..|||.|.:.:|..:.::|...:....:|..|.|.|:..|..||:::|..::|...|.:.||
Zfish    54 SALMEASKAGALKLVRAISKKGGNPNLVDVEGRCAAHFAAEGGFLEVLQVLSAYSADFCVSTTNG 118

  Fly   111 FTPLYMAAQENHDAVVRLLLSNGANQSLATEDGFTPLAVAMQQGHDKVVAVLLESDTRG-KVRLP 174
            .|||:.||....:...|.|...|.|..|...:|..|..||...||...:..|.:::.|. |...|
Zfish   119 NTPLHFAAAGGFNECCRFLSQRGCNPKLRNLEGQLPSQVAKSNGHKAALKELKKAEKRHVKFSAP 183

  Fly   175 -----------------ALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIAS----HYGNQ 218
                             ..|.||.:...::|..|     |..|.:.|..|.:.:.|    ...|:
Zfish   184 DAINPNEPWAITLHDWSCEHEAALRRSFESAVEL-----NKPVQTVSLETFMSLLSTNQAPVSNE 243

  Fly   219 NIANLLIQKGADVNYSAKHNISPLHVAAKW-GKTNMVSLLLEKGGNIE----AKTRDGLT----- 273
            |:..::  |..|.|:....|::......|: .|..::|....|....|    .|.|:..|
Zfish   244 NLQRII--KQHDKNHKNVINLNEFFKGLKYLQKPFVISSYAPKPAKKEKGPKEKKRNKCTSLLPI 306

  Fly   274 ---PLHCAARSGHEQVVDMLLE------------RGAPISAKTKNGLA----------PLHMAAQ 313
               |.....:.....:...::|            |..|.....:|..|          .::...:
Zfish   307 CMMPPELICKREDSGLPYYMIEICQLYTHTKPFNRDQPSIHHIENDSAWYIEPEKIYSNINYCVR 371

  Fly   314 GEHVDAARILLYHRAPVDEVTVDYLTALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIAC 378
            ...:::.|:....:.|||.....|.|.|..|..||:.:||:.|:...||.||.....:||||.||
Zfish   372 SGDLESLRLAFAQQVPVDIKDQFYKTPLLTACSCGNYQVAEFLISLGADVNAVDQFSWTPLHHAC 436

  Fly   379 KKNRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDVPTVRGETPLHLA 443
            ....:.::.:|::.||.:.|...:|.||| :.|...|
Zfish   437 HAGHVDIINMLVQSGAVVDAVAMNGATPL-MRAIESC---------------------------- 472

  Fly   444 ARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLL 488
                :...:..|:..||.|.|..::.|..|.||...||..||.|:
Zfish   473 ----RFSSVECLITAGANVMAENKQGQNCLDIAMIYGNARIVQLI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786
		Ank_4	11..64	CDD:290365	7/17 (41%)
		ANK	38..163	CDD:238125	36/116 (31%)
		ANK repeat	43..74	CDD:293786	8/27 (30%)
		Ank_2	48..135	CDD:289560	27/86 (31%)
		ANK repeat	76..107	CDD:293786	10/30 (33%)
		ANK repeat	109..134	CDD:293786	9/24 (38%)
		Ank_4	110..163	CDD:290365	17/52 (33%)
		Ank_4	172..225	CDD:290365	13/73 (18%)
		ANK repeat	175..202	CDD:293786	7/26 (27%)
		ANK	199..324	CDD:238125	25/163 (15%)
		ANK repeat	204..235	CDD:293786	8/34 (24%)
		Ank_2	209..300	CDD:289560	19/119 (16%)
		ANK repeat	237..268	CDD:293786	6/35 (17%)
		ANK	266..390	CDD:238125	32/153 (21%)
		ANK repeat	270..300	CDD:293786	5/49 (10%)
		ANK repeat	303..367	CDD:293786	19/73 (26%)
		Ank_2	308..399	CDD:289560	26/90 (29%)
		ANK	364..489	CDD:238125	32/124 (26%)
		ANK repeat	369..400	CDD:293786	10/30 (33%)
		ANK repeat	402..433	CDD:293786	6/30 (20%)
		Ank_4	403..456	CDD:290365	6/52 (12%)
		ANK repeat	435..466	CDD:293786	5/30 (17%)
		Ank_2	440..530	CDD:289560	14/48 (29%)
		ANK	463..588	CDD:238125	10/25 (40%)
		ANK repeat	468..497	CDD:293786	9/20 (45%)
		ANK repeat	501..530	CDD:293786
		Ank_2	506..597	CDD:289560
		ANK	529..654	CDD:238125
		ANK repeat	535..565	CDD:293786
		ANK repeat	567..598	CDD:293786
		Ank_2	572..661	CDD:289560
		ANK repeat	600..630	CDD:293786
		ANK repeat	633..662	CDD:293786
		ANK	661..785	CDD:238125
		ANK repeat	666..697	CDD:293786
		Ank_2	672..762	CDD:289560
		ANK repeat	699..730	CDD:293786
		ANK repeat	732..762	CDD:293786
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
ankef1b	XP_021322982.1	ANK	10..137	CDD:238125	26/82 (32%)
		ANK repeat	53..82	CDD:293786	8/27 (30%)
		ANK repeat	84..115	CDD:293786	10/30 (33%)
		ANK repeat	117..148	CDD:293786	12/30 (40%)
		Ank_4	118..170	CDD:316185	17/51 (33%)
		ANK	389..513	CDD:238125	43/156 (28%)
		ANK repeat	397..425	CDD:293786	12/27 (44%)
		ANK repeat	427..458	CDD:293786	10/30 (33%)
		ANK repeat	460..491	CDD:293786	11/63 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000