DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ank2 and ankrd52

DIOPT Version :9

Sequence 1:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster
Sequence 2:	XP_012811808.1	Gene:	ankrd52 / 100127696	XenbaseID:	XB-GENE-1002005	Length:	1070	Species:	Xenopus tropicalis

Alignment Length:	990	Identity:	287/990 - (28%)
Similarity:	396/990 - (40%)	Gaps:	220/990 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 NLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAIVDSATKKGNTALHIASLA 87
            |||.|...|....::|..:....:.||.|:..|.|.|:..|::.||.|::......|.||.|..:
Frog    20 NLEEVRALLSQKDNVNVLDQERRSPLHAAAYLGDIPVIELLIQSGANVNAKDSVWLTPLHRAVAS 84

  Fly    88 GQEEVVKLLLEHNASVNVQSQNGFTPLYMAA---------------------------------- 118
            ..|..|.||::|:|.||.:.::..|||::||
Frog    85 RNERAVSLLVKHSADVNARDKHWQTPLHIAAANRANKCAETLIPLVKNVNLADRTGRTALHHAVL 149

  Fly   119 ----------------------QENHD----------AVVRLLLSNGANQSLATEDGFTPLAVAM 151
                                  :|.|.          .:.:||:|.||:.....:.|:|||..|.
Frog   150 SGNLEMVVMLLNKRAHHSICDKKERHPIIYASFLGLLEIAKLLISRGADAMSKDKKGYTPLHAAA 214

  Fly   152 QQGHDKVVAVLL----ESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKSGFTPLHIA 212
            ..|...||..||    |.|........|||||........|..|::...|.:..::.||||||.|
Frog   215 SSGQIDVVKYLLKLGVEIDEPNAFGNTALHIACYMGQDAVANELVNYGSNVNQPNEKGFTPLHFA 279

  Fly   213 SHYGNQNIA-NLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKTRDGLTPLH 276
            :...|..:. .||:..|||||:.:|...||||:||..|:.....:|::.||.|:...:.|.||||
Frog   280 AVSTNGALCLELLVNNGADVNFQSKEGKSPLHMAAIHGRFTRSQILIQNGGEIDCADKYGNTPLH 344

  Fly   277 CAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILLYH--------------- 326
            .|||.|||.::..|:..||..:.:..:|:.|||:|......|..|.||..
Frog   345 VAARYGHELLISTLMTNGADTARRGVHGMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHV 409

  Fly   327 -RAPVDEVTVDYL--TALHVAAHCGHVRVAKLLLDRNADANARALNGFTPLHIACKKNRLKVVEL 388
             .|..|..|.|.|  |.||.||..|:|....||....||...|...|.||||.|......:.:..
Frog   410 LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLSSSGADLKRRDKFGRTPLHYAAANGSYQCIVS 474

  Fly   389 LLRHGASISATTESGLTPLHVAAFMG------------------------------CMNIVIYLL 423
            |:..||||:.....|.||||.||...                              |:.   |||
Frog   475 LVTAGASINEADYKGCTPLHYAAASDTYRRVDTHSGTSQEPEEELLKASRQKEAFFCLE---YLL 536

  Fly   424 QHDASP-----------------------------------DVPTVRGETPLHLAARANQTDIIR 453
            .::|.|                                   ||.:....:||||||.....|.::
Frog   537 DNNADPSLRDKQGYSAVHYAAAYGNRQNLELLLEMSFNCLEDVESTVPVSPLHLAAFNGHCDALK 601

  Fly   454 ILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVDATTKD---MYTALHIAAKEGQD 515
            .|......:|....:.:|.|::|:..|:.|.|.:|..|||  ....||   .:|.||.||..|..
Frog   602 TLAETLVNLDVCDHKGRTALYLATERGSTDCVSVLTSHGA--SPLIKDRRKKWTPLHAAAASGNI 664

  Fly   516 EVAAVLI---ENGAALDAATKKGFTPLHLTAKYGHIKVAQLLLQKEADVDAQGKNGVTPLHVACH 577
            :...:||   |.....|.....|.|||.|....||:..|.|||:|.|.|||..|.|.|.||.|..
Frog   665 DCLHLLIDCSERPDITDVMDAHGQTPLMLAVMNGHVDCAHLLLEKGATVDAGDKKGRTTLHRASV 729

  Fly   578 YNNQQVALLLLE----------KGASP--------HATA-------------------KNGHTPL 605
            ...:.....|:|          ||.:|        |||.                   .||:||:
Frog   730 TGCEDCVGALMEHDAFVLCRDFKGRTPIHFAAACGHATLVHVYLQAALSTDPLDAVVDYNGYTPM 794

  Fly   606 HIAARKNQMDIATTLLEYGALANAESKAGFTPLH---LSSQEGHAEISNLLIEHKAA--VNHPAK 665
            |.||.....|....|||:...|..|... |||||   ::||:|.|:   ||:|...|  ||....
Frog   795 HWAAYNGHEDCLELLLEHNPFAYLEGNP-FTPLHCAVINSQDGTAD---LLVEALGAKIVNSRDA 855

  Fly   666 NGLTPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLL-QNGANVDAA 729
            .|.||:|..|..||||..::|..:.|.::....:|.|||.:::..|:...|.||| ...|::...
Frog   856 KGRTPLHAAAFADNVNGLQLLLHHQAEVNATDLSGRTPLMMSAENGRTAAVEFLLFHMKADLTVM 920

  Fly   730 TSIGYTPLHQTAQQGHCHIVNLLLEHKAN---ANAQTVNGQTPLHIARKLGYISVLDSLKT---- 787
            .....|.||....:||.....|||....:   .||.....|.|||||.:.|..||:.:|.|
Frog   921 DINKNTALHLACSKGHEKCALLLLGETRDLGLINATNSMLQMPLHIAARNGLASVVQALLTRGAT 985

  Fly   788 -ITKEDETAAAPSQA 801
             :..::|....|:.|
Frog   986 VLAVDEEAGHTPALA 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	6/17 (35%)
		Ank_4	11..64	CDD:290365	12/40 (30%)
		ANK	38..163	CDD:238125	43/190 (23%)
		ANK repeat	43..74	CDD:293786	10/30 (33%)
		Ank_2	48..135	CDD:289560	33/152 (22%)
		ANK repeat	76..107	CDD:293786	12/30 (40%)
		ANK repeat	109..134	CDD:293786	10/90 (11%)
		Ank_4	110..163	CDD:290365	20/118 (17%)
		Ank_4	172..225	CDD:290365	17/53 (32%)
		ANK repeat	175..202	CDD:293786	8/26 (31%)
		ANK	199..324	CDD:238125	48/125 (38%)
		ANK repeat	204..235	CDD:293786	15/31 (48%)
		Ank_2	209..300	CDD:289560	37/91 (41%)
		ANK repeat	237..268	CDD:293786	11/30 (37%)
		ANK	266..390	CDD:238125	46/141 (33%)
		ANK repeat	270..300	CDD:293786	14/29 (48%)
		ANK repeat	303..367	CDD:293786	25/81 (31%)
		Ank_2	308..399	CDD:289560	35/108 (32%)
		ANK	364..489	CDD:238125	42/189 (22%)
		ANK repeat	369..400	CDD:293786	11/30 (37%)
		ANK repeat	402..433	CDD:293786	15/95 (16%)
		Ank_4	403..456	CDD:290365	22/117 (19%)
		ANK repeat	435..466	CDD:293786	9/30 (30%)
		Ank_2	440..530	CDD:289560	29/95 (31%)
		ANK	463..588	CDD:238125	45/130 (35%)
		ANK repeat	468..497	CDD:293786	10/28 (36%)
		ANK repeat	501..530	CDD:293786	10/34 (29%)
		Ank_2	506..597	CDD:289560	37/111 (33%)
		ANK	529..654	CDD:238125	54/164 (33%)
		ANK repeat	535..565	CDD:293786	16/29 (55%)
		ANK repeat	567..598	CDD:293786	12/48 (25%)
		Ank_2	572..661	CDD:289560	37/130 (28%)
		ANK repeat	600..630	CDD:293786	12/29 (41%)
		ANK repeat	633..662	CDD:293786	14/33 (42%)
		ANK	661..785	CDD:238125	41/127 (32%)
		ANK repeat	666..697	CDD:293786	11/30 (37%)
		Ank_2	672..762	CDD:289560	27/93 (29%)
		ANK repeat	699..730	CDD:293786	10/31 (32%)
		ANK repeat	732..762	CDD:293786	9/32 (28%)
		ZU5	927..1030	CDD:128514
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
ankrd52	XP_012811808.1	ANK repeat	9..38	CDD:293786	6/17 (35%)
		Ank_4	10..61	CDD:290365	12/40 (30%)
		ANK	35..160	CDD:238125	28/124 (23%)
		ANK repeat	40..71	CDD:293786	10/30 (33%)
		Ank_2	45..137	CDD:289560	27/91 (30%)
		ANK repeat	76..104	CDD:293786	12/27 (44%)
		ANK repeat	106..137	CDD:293786	5/30 (17%)
		ANK	134..259	CDD:238125	25/124 (20%)
		ANK repeat	139..170	CDD:293786	0/30 (0%)
		Ank_4	140..193	CDD:290365	3/52 (6%)
		ANK repeat	172..203	CDD:293786	7/30 (23%)
		Ank_2	177..269	CDD:289560	25/91 (27%)
		ANK repeat	206..236	CDD:293786	12/29 (41%)
		ANK	233..359	CDD:238125	47/125 (38%)
		ANK repeat	238..269	CDD:293786	8/30 (27%)
		Ank_2	243..336	CDD:289560	34/92 (37%)
		ANK repeat	271..300	CDD:293786	13/28 (46%)
		ANK repeat	305..336	CDD:293786	11/30 (37%)
		ANK repeat	338..363	CDD:293786	12/24 (50%)
		Ank_4	339..392	CDD:290365	21/52 (40%)
		ANK repeat	375..420	CDD:293786	11/44 (25%)
		Ank_2	376..486	CDD:289560	35/109 (32%)
		ANK	417..569	CDD:238125	39/154 (25%)
		ANK repeat	423..453	CDD:293786	11/29 (38%)
		ANK repeat	455..486	CDD:293786	11/30 (37%)
		Ank_2	460..574	CDD:289560	21/116 (18%)
		ANK repeat	488..546	CDD:293786	13/60 (22%)
		ANK repeat	586..614	CDD:293786	9/27 (33%)
		Ank_2	588..681	CDD:289560	29/94 (31%)
		ANK	611..740	CDD:238125	45/130 (35%)
		ANK repeat	617..647	CDD:293786	10/31 (32%)
		ANK repeat	652..681	CDD:293786	9/28 (32%)
		Ank_2	655..750	CDD:289560	33/94 (35%)
		ANK	681..810	CDD:238125	39/128 (30%)
		ANK repeat	686..717	CDD:293786	16/30 (53%)
		ANK repeat	719..750	CDD:293786	7/30 (23%)
		ANK repeat	752..783	CDD:293786	6/30 (20%)
		Ank_4	753..810	CDD:290365	13/56 (23%)
		ANK repeat	789..818	CDD:293786	12/28 (43%)
		Ank_2	795..887	CDD:289560	35/95 (37%)
		ANK repeat	820..854	CDD:293786	15/37 (41%)
		ANK	851..980	CDD:238125	41/128 (32%)
		ANK repeat	856..887	CDD:293786	11/30 (37%)
		ANK repeat	889..921	CDD:293786	10/31 (32%)
		Ank_2	894..990	CDD:289560	28/95 (29%)
		ANK repeat	923..957	CDD:293786	10/33 (30%)
		ANK repeat	959..990	CDD:293786	11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53364at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010