DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KRT35 and LamC

DIOPT Version :9

Sequence 1:	NP_002271.3	Gene:	KRT35 / 3886	HGNCID:	6453	Length:	455	Species:	Homo sapiens
Sequence 2:	NP_001260974.1	Gene:	LamC / 36615	FlyBaseID:	FBgn0010397	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	458	Identity:	120/458 - (26%)
Similarity:	194/458 - (42%)	Gaps:	73/458 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    50 SACSVGLGRSSYRATSCLPALCLPAGGFATSYSGGGGWFGEGILTG--NEKETMQSLNDRLAGYL 112
            ||..|.|.....||::     ..|.||.:||...|.........|.  .|||.:|.||||||.|:
  Fly     2 SARRVTLNTRVSRAST-----STPVGGASTSSRVGATSPTSPTRTSRQQEKEELQHLNDRLACYI 61

Human   113 EKVRQLEQENASLESRI---REWCEQQVPYMCPDYQSYFRTIEELQKKTLCSKAENARLVVEIDN 174
            :::|.||.||:.|...:   ::...::...:...|:.......:|..:|...||:     :|||.
  Fly    62 DRMRNLENENSRLTQELNLAQDTVNRETSNLKAVYEKELAAARKLLDETAKEKAK-----LEIDI 121

Human   175 AKL--AADDFRTKYETEVSLRQLVE----------SDING------------------------- 202
            .:|  ..||.:.:.:.:.....:.|          :::||
  Fly   122 KRLWEENDDLKPRLDKKTKEATVAENNARLYENRYNEVNGKYNQSLADRKKFEDQAKELALENER 186

Human   203 LRRILDDL-------TLCKSDLEAQVESLKEELLCLKKNHEEEVNSLR-------CQLGDRLNVE 253
            |||.||||       ||.:.|||.|.:||:|||....:.|.:|:...|       .::..||:.:
  Fly   187 LRRQLDDLRKQLEAETLARVDLENQNQSLREELAFKDQVHTQELTETRSRRQIEISEIDGRLSRQ 251

Human   254 VDAAPPVDLNRVLEEMRCQYETLVENNRRDAEDWLDTQSEELNQQVVSSSEQLQSCQAEIIELRR 318
            .:|    .|.:.|:|:|.|||..:..||.:.|...|.:.:.| :...:.:.|..:...|.:.|.|
  Fly   252 YEA----KLQQSLQELRDQYEGQMRINREEIELLYDNEIQNL-KAAANRAAQGSALATEEVRLMR 311

Human   319 T-VNALEIELQAQHSMRDALESTLAETEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEYQV 382
            | ::.|..:||........|.:.:.|.|....::..:....|.::||:|..:|.::..|.||||.
  Fly   312 TKIDGLNAKLQNLEDTNAGLNARIRELENLLDTERQRHNQYIASLEAELQRMRDEMAHQLQEYQG 376

Human   383 LLDVRARLECEINTYRGLLESEDSKLPC-NPCAPDYSPSKSCLPCLPAASCGPSAARTNCSPRPI 446
            |:|::..|:.||..|..||..|:.:|.. :|..|......|.......||....:.|...|.|..
  Fly   377 LMDIKVSLDLEIAAYDKLLCGEERRLNIESPGRPTTDSGISSNGSHLTASASSRSGRVTPSGRRS 441

Human   447 CVP 449
            ..|
  Fly   442 ATP 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT35	NP_002271.3	Head	1..97		13/48 (27%)
		Filament	96..407	CDD:278467	97/365 (27%)
		Coil 1A	98..132		16/36 (44%)
		Linker 1	133..143		0/9 (0%)
		Coil 1B	144..244		35/150 (23%)
		Linker 12	245..260		3/14 (21%)
		Coil 2	261..404		41/143 (29%)
		Tail	405..455		10/46 (22%)
LamC	NP_001260974.1	Filament	45..401	CDD:278467	97/365 (27%)
		ATP-synt_B	<67..>142	CDD:304375	16/79 (20%)
		MreC	<178..>224	CDD:302802	18/45 (40%)
		LTD	473..574	CDD:279300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910