DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment KRT35 and krt34

DIOPT Version :9

Sequence 1:	NP_002271.3	Gene:	KRT35 / 3886	HGNCID:	6453	Length:	455	Species:	Homo sapiens
Sequence 2:	XP_002939082.4	Gene:	krt34 / 100491736	XenbaseID:	XB-GENE-6051335	Length:	400	Species:	Xenopus tropicalis

Alignment Length:	337	Identity:	199/337 - (59%)
Similarity:	252/337 - (74%)	Gaps:	6/337 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    75 GGFATSYSG----GGGWFG--EGILTGNEKETMQSLNDRLAGYLEKVRQLEQENASLESRIREWC 133
            ||...|:.|    |||..|  ||:|...||||||.||||||.||.:||.||:||...|.|||||.
Frog    29 GGLRGSFGGHCGMGGGLGGRSEGLLNVGEKETMQQLNDRLANYLGRVRSLEEENGQFERRIREWY 93

Human   134 EQQVPYMCPDYQSYFRTIEELQKKTLCSKAENARLVVEIDNAKLAADDFRTKYETEVSLRQLVES 198
            ::||||..||:.::||||||||.|.|.:...||.|:::||||:|.:||||.|:|:|.:.|..||.
Frog    94 DKQVPYNFPDFNNFFRTIEELQNKILHACTGNANLILQIDNARLTSDDFRNKFESEAAFRMGVEG 158

Human   199 DINGLRRILDDLTLCKSDLEAQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLN 263
            |:|||||:|::|.|..:|.|.|.::|.|||..|||||.|||.|||.|||.|:||||:|||.||||
Frog   159 DMNGLRRVLEELNLGNNDQEIQRQNLSEELTYLKKNHAEEVGSLRTQLGARVNVEVNAAPAVDLN 223

Human   264 RVLEEMRCQYETLVENNRRDAEDWLDTQSEELNQQVVSSSEQLQSCQAEIIELRRTVNALEIELQ 328
            :||.|:|.||||:||.|||:||:|...:|||||||:.||::|||:...|:|:||.||..|||:||
Frog   224 QVLGEIRDQYETIVERNRREAENWFLNKSEELNQQMNSSADQLQTVHTEVIQLRNTVQGLEIDLQ 288

Human   329 AQHSMRDALESTLAETEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEYQVLLDVRARLECE 393
            :|:|||.|||.|||:||:||..||:|:|.:|.|||.||..:|:||||||.||:.|:||:..||.|
Frog   289 SQNSMRSALEGTLADTESRYGGQLSQLQFLINNVETQLGSLRSDLERQNFEYKALMDVKTHLEME 353

Human   394 INTYRGLLESED 405
            |.|||.||:.||
Frog   354 IATYRRLLDGED 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT35	NP_002271.3	Head	1..97		11/27 (41%)
		Filament	96..407	CDD:278467	188/310 (61%)
		Coil 1A	98..132		23/33 (70%)
		Linker 1	133..143		4/9 (44%)
		Coil 1B	144..244		54/99 (55%)
		Linker 12	245..260		11/14 (79%)
		Coil 2	261..404		87/142 (61%)
		Tail	405..455		1/1 (100%)
krt34	XP_002939082.4	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1715
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D259189at7742
OrthoFinder	1	1.000	-	-		FOG0000094
OrthoInspector	1	1.000	-	-		otm55265
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010