DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33965 and Sec14l1

DIOPT Version :9

Sequence 1:	NP_001033983.1	Gene:	CG33965 / 3885668	FlyBaseID:	FBgn0053965	Length:	317	Species:	Drosophila melanogaster
Sequence 2:	NP_083053.2	Gene:	Sec14l1 / 74136	MGIID:	1921386	Length:	719	Species:	Mus musculus

Alignment Length:	277	Identity:	52/277 - (18%)
Similarity:	110/277 - (39%)	Gaps:	61/277 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LNEVPSRVESDIAALKEWLQKQPHLCACLEDQFLLSFLRGSKFSLEKAKQ------------KID 76
            |.::....||.:..|::||| :.|.....:|:.:|.|||...|:::||::            ::|
Mouse   248 LGDLTPLQESCLIRLRQWLQ-ETHKGKIPKDEHILRFLRARDFNIDKAREIMCQSLTWRKQHQVD 311

  Fly    77 RFYSLQAVIPEVFNDQRLVD-----------NAQVLEIIRLGVILRIPLDEEDTGPAVTIIRA-G 129
              |.|....|    .|.|:|           :.:.|.::|||        :.||   ..::|| |
Mouse   312 --YILDTWTP----PQVLLDYYAGGWHHHDKDGRPLYVLRLG--------QMDT---KGLVRALG 359

  Fly   130 SYDINKFKFQDIIRVGSMFGEIMMLEDDNASV-----SGYLEIMDMSGVTGANLFALQPQLLSKF 189
            ...:.::       |.|:..|.:...::|..|     |.:..::|:.|:...:|:....:.|.:.
Mouse   360 EEALLRY-------VLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKALLRI 417

  Fly   190 SAYADEAMPTRQKGIHFINVPKAFETGFKSLLGWFPGKIKER--VSVSSD---PEAIFERVPKHY 249
            ....:...|.....:..:..|:.|...:..:..:.....:.:  :...:|   |..:.:.:.|..
Mouse   418 IEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEI 482

  Fly   250 LPEEYGGSKGTMKDITD 266
            :|:...|.  .|.|:.:
Mouse   483 IPDFLSGE--CMCDVPE 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33965	NP_001033983.1	CRAL_TRIO_N	32..77	CDD:215024	15/56 (27%)
CG33965	NP_001033983.1	SEC14	101..256	CDD:238099	26/165 (16%)
Sec14l1	NP_083053.2	Required for interaction and inhibitory function toward DDX58. /evidence=ECO:0000250\|UniProtKB:Q92503	1..510		52/277 (19%)
		PRELI	17..173	CDD:282550
		CRAL_TRIO_N	256..301	CDD:215024	15/45 (33%)
		CRAL_TRIO	326..490	CDD:279044	26/181 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810