DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34031 and ESX1

DIOPT Version :9

Sequence 1:	NP_001246894.1	Gene:	CG34031 / 3885665	FlyBaseID:	FBgn0054031	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_703149.1	Gene:	ESX1 / 80712	HGNCID:	14865	Length:	406	Species:	Homo sapiens

Alignment Length:	245	Identity:	54/245 - (22%)
Similarity:	91/245 - (37%)	Gaps:	83/245 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EKSIQTKKKGKLGAFSIDSILSTSEAHSSQNSLPKDNTNVTSSDISKLYAFSFTQEG-------- 73
            |....|:.|.:.|..:.:::       .::.|:|.|:.:               :||
Human    42 EDEENTRSKPEYGTEAENNV-------GTEGSVPSDDQD---------------REGGGGHEPEQ 84

  Fly    74 -NNKTPLTNFDLCQGHPRRLPI----------TFDGSTVSRFVWRTESILPSYITNSTNLQEKQL 127
             ..:.|||..:..|..|..|.:          |.:|              |.........:..|.
Human    85 QQEEPPLTKPEQQQEEPPLLELKQEQEEPPQTTVEG--------------PQPAEGPQTAEGPQP 135

  Fly   128 RKRFTDRKPRQAYSASQLERLENEFNLDKYLSVSKRVELSKSLSLTEVQVKTWFQNRRTKWKK-- 190
            .:|  .|:.|.|::..||:.|||.|:..:|..|..|..|:..|:|||.:|:.||||||.|||:
Human   136 PER--KRRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQVWFQNRRAKWKRNQ 198

  Fly   191 -----QLTSRLKIAHRHGLW-------------------IPTLPITTIIP 216
                 :.|:...:||...::                   :|.||...::|
Human   199 RVLMLRNTATADLAHPLDMFLGGAYYAAPALDPALCVHLVPQLPRPPVLP 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34031	NP_001246894.1	Homeobox	136..189	CDD:278475	24/52 (46%)
ESX1	NP_703149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..142		21/137 (15%)
		Nuclear localization signal. /evidence=ECO:0000255	138..143		2/6 (33%)
		Homeobox	142..195	CDD:278475	24/52 (46%)
		15 X 9 AA tandem repeats of P-P-x-x-P-x-P-P-x	244..378		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..364
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910