DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34031 and Nanog

DIOPT Version :9

Sequence 1:	NP_001246894.1	Gene:	CG34031 / 3885665	FlyBaseID:	FBgn0054031	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_082292.1	Gene:	Nanog / 71950	MGIID:	1919200	Length:	305	Species:	Mus musculus

Alignment Length:	165	Identity:	47/165 - (28%)
Similarity:	77/165 - (46%)	Gaps:	27/165 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SILSTSEAHSSQN--SLP----KDNTNVTSSDISKLYAFSFTQEGNNKTPLTNFDLCQGHPRRLP 93
            |:.|:.||.:|.|  |:|    .:|.:......:::..   |:..:.:....:..| ||.|
Mouse    10 SLPSSEEASNSGNASSMPAVFHPENYSCLQGSATEMLC---TEAASPRPSSEDLPL-QGSP---- 66

  Fly    94 ITFDGSTVSRFVWRTESILPSYITNSTNLQEKQLRKRFTDRKPRQAYSASQLERLENEFNLDKYL 158
               |.||..:     :.:...........:|.::..|  .:|.|..:|.:||..|::.|...|||
Mouse    67 ---DSSTSPK-----QKLSSPEADKGPEEEENKVLAR--KQKMRTVFSQAQLCALKDRFQKQKYL 121

  Fly   159 SVSKRVELSKSLSLTEVQVKTWFQNRRTK---WKK 190
            |:.:..|||..|:|:..||||||||:|.|   |:|
Mouse   122 SLQQMQELSSILNLSYKQVKTWFQNQRMKCKRWQK 156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34031	NP_001246894.1	Homeobox	136..189	CDD:278475	25/55 (45%)
Nanog	NP_082292.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..95		9/64 (14%)
		Sufficient for interaction with SALL4. /evidence=ECO:0000269\|PubMed:16840789	96..155		26/58 (45%)
		HOX	96..152	CDD:197696	26/55 (47%)
		Required for DNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9H9S0	123..152		15/28 (54%)
		10 X repeats starting with a Trp in each unit	198..247
		Sufficient for transactivation activity	198..247
		Sufficient for strong transactivation activity	248..305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910