DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34031 and lbx2

DIOPT Version :9

Sequence 1:	NP_001246894.1	Gene:	CG34031 / 3885665	FlyBaseID:	FBgn0054031	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_001007135.1	Gene:	lbx2 / 64276	ZFINID:	ZDB-GENE-001206-2	Length:	257	Species:	Danio rerio

Alignment Length:	199	Identity:	58/199 - (29%)
Similarity:	82/199 - (41%)	Gaps:	39/199 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RLNSCIEKSIQTKKKGKLG-------------AFSIDSILSTSEAHSSQNSL--PKDNTNVTSSD 60
            :..|.::.|.:.:::|.|.             .|||:.||:......|..||  |:....||.|.
Zfish     9 KAGSVLQSSGEERRRGPLDQLPPPANSNKPLTPFSIEDILNKPSVKKSVGSLCPPRVLEKVTGSS 73

  Fly    61 ISKLYAFSFTQEGNNKTPLTNFDLCQGHPRRLPITFDGSTVSRFVWRTESILPSYITNSTNL--Q 123
            .|:           |.....:..|| ........||.|..|| .:...|.      ....|.  |
Zfish    74 ASR-----------NGISAPSSPLC-ALEELASKTFKGLEVS-VIQAAEG------REHINAFGQ 119

  Fly   124 EKQLRKRFTDRKPRQAYSASQLERLENEFNLDKYLSVSKRVELSKSLSLTEVQVKTWFQNRRTKW 188
            .:..:||   ||.|.|::..|:..||..|...||||.:.|.::::.|.||..||.|||||||.|.
Zfish   120 RQASKKR---RKSRTAFTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKL 181

  Fly   189 KKQL 192
            |:.|
Zfish   182 KRDL 185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34031	NP_001246894.1	Homeobox	136..189	CDD:278475	24/52 (46%)
lbx2	NP_001007135.1	Required for convergent extension movement and hypaxial myogenesis during gastrulation. Required for the formation of thick and thin myofilaments. Required for myod1 expression in the pectoral fin bud. Required for continuous expression of cxcl12a in the posterior lateral mesoderm at the tail bud stage and in adaxial cells at the 10-somite stage. /evidence=ECO:0000269\|PubMed:19216761, ECO:0000269\|PubMed:22216300, ECO:0000269\|PubMed:22406073	1..46		7/36 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		4/33 (12%)
		Homeobox	129..183	CDD:395001	24/53 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..257
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810