DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34031 and HOXA2

DIOPT Version :9

Sequence 1:	NP_001246894.1	Gene:	CG34031 / 3885665	FlyBaseID:	FBgn0054031	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_006726.1	Gene:	HOXA2 / 3199	HGNCID:	5103	Length:	376	Species:	Homo sapiens

Alignment Length:	224	Identity:	64/224 - (28%)
Similarity:	91/224 - (40%)	Gaps:	56/224 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNPHLEQDKSRLNS------CIEKSIQTKKKGKLGAFSIDSILSTSEAHSSQNSLPKDNTNVTSS 59
            ||...|::...:||      |:     |........|...||.:::.:||:....|.:.|
Human     1 MNYEFEREIGFINSQPSLAECL-----TSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQT----- 55

  Fly    60 DISKLYAFSFTQEGNNKTPLTNFDLCQGHPRRLPITFDGSTV-------SRFVWRTE-------S 110
             |..|...|..:.|           ..|.|:..|....||.|       ..:.|..|       :
Human    56 -IPSLNPGSHPRHG-----------AGGRPKPSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTA 108

  Fly   111 ILPSYITNSTN-------LQEKQLRKRFTD------RKPRQAYSASQLERLENEFNLDKYLSVSK 162
            :||:....:|.       |..|: .....|      |:.|.||:.:||..||.||:.:|||...:
Human   109 LLPAAAAAATAAATGPACLSHKE-SLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPR 172

  Fly   163 RVELSKSLSLTEVQVKTWFQNRRTKWKKQ 191
            |||::..|.|||.|||.||||||.|.|:|
Human   173 RVEIAALLDLTERQVKVWFQNRRMKHKRQ 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34031	NP_001246894.1	Homeobox	136..189	CDD:278475	29/52 (56%)
HOXA2	NP_006726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..93		14/67 (21%)
		Antp-type hexapeptide	94..99		1/4 (25%)
		Homeobox	147..200	CDD:395001	29/52 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..229		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000