DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34031 and HLX

DIOPT Version :9

Sequence 1:	NP_001246894.1	Gene:	CG34031 / 3885665	FlyBaseID:	FBgn0054031	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_068777.1	Gene:	HLX / 3142	HGNCID:	4978	Length:	488	Species:	Homo sapiens

Alignment Length:	174	Identity:	47/174 - (27%)
Similarity:	73/174 - (41%)	Gaps:	30/174 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 HSSQNSLPKDNTNVTSSDISKLYAFSF---TQEGNNKTPLTNFDLCQGHPRRLPITFDGSTVSRF 104
            ||  .|.|..::......|.::.:..|   .:|||....||:. |..|.|..:.::....:..:|
Human   162 HS--GSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSL-LTGGRPAGVHLSGLQPSAGQF 223

  Fly   105 ------VWRTESILPSYITNSTNLQEKQLRKRF--------TDRKP----------RQAYSASQL 145
                  :....:||....:|..|..:.|.:..|        .|..|          |..:|..|.
Human   224 FASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKRSWSRAVFSNLQR 288

  Fly   146 ERLENEFNLDKYLSVSKRVELSKSLSLTEVQVKTWFQNRRTKWK 189
            :.||..|.:.||::...|.:|:..|.||:.|||.||||||.||:
Human   289 KGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWR 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34031	NP_001246894.1	Homeobox	136..189	CDD:278475	24/62 (39%)
HLX	NP_068777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..173		4/12 (33%)
		Abdominal-A	227..>344	CDD:332641	32/106 (30%)
		Homeobox	279..332	CDD:306543	23/52 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..488		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810