DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34031 and DUX4

DIOPT Version :9

Sequence 1:	NP_001246894.1	Gene:	CG34031 / 3885665	FlyBaseID:	FBgn0054031	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_001280727.1	Gene:	DUX4 / 100288687	HGNCID:	50800	Length:	424	Species:	Homo sapiens

Alignment Length:	80	Identity:	23/80 - (28%)
Similarity:	39/80 - (48%)	Gaps:	13/80 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 NLQEKQLRKRFTDRKP-------------RQAYSASQLERLENEFNLDKYLSVSKRVELSKSLSL 172
            |.:.:|||:...:.:|             |.|.:.||...|...|..|::..::.|.||::...|
Human    69 NERSRQLRQHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGL 133

  Fly   173 TEVQVKTWFQNRRTK 187
            .|.:::.||||||.:
Human   134 PESRIQIWFQNRRAR 148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34031	NP_001246894.1	Homeobox	136..189	CDD:278475	19/65 (29%)
DUX4	NP_001280727.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Homeobox	27..74	CDD:306543	1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..102		6/29 (21%)
		Homeobox	97..149	CDD:306543	18/52 (35%)
		DNA_pol3_gamma3	<141..319	CDD:331207	6/8 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..362
		Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269\|PubMed:26951377	327..424
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..414
		Important for transcriptional activation of target genes. /evidence=ECO:0000269\|PubMed:29618456	405..424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910