Protein Alignment Mitf and HMS1

DIOPT Version :9

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_014675.1
• Gene: HMS1 / 854197
• SGDID: S000005558
• Length: 434
• Species: Saccharomyces cerevisiae
• Alignment Length: 487
• Identity: 112/487 - (22%)
• Similarity: 170/487 - (34%)
• Gaps: 169/487 - (34%)

  Fly   214 GSGQGLMESEFIDSGSTSA-----CGSGSSSLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGVDVP 273
            ||..|  .|...|.|:..|     |.|.....|:.:..|..:         ::.:..||...:||
Yeast    10 GSSDG--NSVMNDLGNKVAIKVFDCRSAQDGSEEQNVNVTTN---------QMYLMFQSNNYNVP 63

  Fly   274 PQVLQVSTVLEN--PTR------YHVIQKQ-------KNQ----VRQYLSESFKPSMWGSHTSEI 319
            |.......:...  ||.      .|.|..|       ||.    ..||...|| |:..| ||..|
Yeast    64 PPNYNTEDLGSQGPPTHAYYAPFQHPIHLQPPVPPVYKNNTYSATDQYSDSSF-PNTSG-HTPVI 126

  Fly   320 KLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDIN 384
                    ..|..|.:|.                             ::|.:..|.:.:..|:.|
Yeast   127 --------DSNYYNDALA-----------------------------SIPTTTTGSTTMTTDNGN 154

  Fly   385 PIEPTVLRPNSH--GAGEPENAHRTAQLGL-SKANSSLSSTRS------SSGIVNSIRISSTSSS 440
            .|:......|..  .:.|.||.....|..| |:.:|||.|..|      .||..|.:.:|.|.|.
Yeast   155 TIDSEEYIDNMEVFSSEENENIDNVKQTDLKSEKDSSLLSAASIVKKEQLSGFENFLPLSKTESP 219

  Fly   441 LQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFD-------KNFNSELSIKQEPQNLTDAE 498
            | .|:..|..|::            .::|...||.:|.       |:|:      .:|:.:|
Yeast   220 L-VTADEIKSSLN------------LENIDNADSMSFKLKTSPIRKHFH------VKPKRIT--- 262

  Fly   499 MNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYE------VVRDI--------- 548
                 :.|..:.:||:||::.|.||||:|::|...:|....|:.:      ..||:
Yeast   263 -----RVRTGRVSHNIIEKKYRSNINDKIEQLRRTVPTLRVAYKKCNDLPITSRDLADLDGLEPA 322

  Fly   549 -RPNKGTILKSSVDYI-----KCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGIL 607
             :.||.:||..|::||     |||               |:.|.|:.|.:..::
Yeast   323 TKLNKASILTKSIEYICHLERKCL---------------QLSLANQHLSNDTRD----------- 361

  Fly   608 LSENHLTSLSAPTQPYLKSFSLSPTASRSRRS 639
             |..|||.   |:|| |...|.|....:..||
Yeast   362 -SFVHLTE---PSQP-LSDNSSSEQVQKQTRS 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	15/57 (26%)
		HLH	505..570	CDD:238036	26/85 (31%)
HMS1	NP_014675.1	bHLHzip_scHMS1_like	265..363	CDD:381405	30/124 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030