Protein Alignment Mitf and CBF1

DIOPT Version :9

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_012594.1
• Gene: CBF1 / 853523
• SGDID: S000003821
• Length: 351
• Species: Saccharomyces cerevisiae
• Alignment Length: 354
• Identity: 83/354 - (23%)
• Similarity: 140/354 - (39%)
• Gaps: 71/354 - (20%)

  Fly   290 HVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDS 354
            |..:|:.....|..||:.|..      .:..|.:..::.||:.::.|.:|.  .|:.|.......
Yeast    18 HSARKRGYNEEQNYSEARKKQ------RDQGLLSQESNDGNIDSALLSEGA--TLKGTQSQYESG 74

  Fly   355 AVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNSH-----GAGEPENAHRTAQLGLS- 413
            ..|.|....|||              :|.:..|..|....::     |..:..:||.:.|...:
Yeast    75 LTSNKDEKGSDD--------------EDASVAEAAVAATVNYTDLIQGQEDSSDAHTSNQTNANG 125

  Fly   414 ----KANSSLSSTRSSSGI-VNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQND 473
                ..|...:.|.|:.|: .|:.....|||.::||....:..:..:|.....|:...||   .|
Yeast   126 EHKDSLNGERAITPSNEGVKPNTSLEGMTSSPMESTQQSKNDMLIPLAEHDRGPEHQQDD---ED 187

  Fly   474 SFNFDKNFNSELSIK-----QEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTL 533
            :.:.|.:...::|::     ::|..|...:    ...:|:||:|..:|||||.|||..|..|..|
Yeast   188 NDDADIDLKKDISMQPGRRGRKPTTLATTD----EWKKQRKDSHKEVERRRRENINTAINVLSDL 248

  Fly   534 LPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKH------EVTRLRQ--NELRQRQVELQNRKL 590
            ||         ||:  .:|..||..:.:||:.||.      |...|::  :|....|:...|.||
Yeast   249 LP---------VRE--SSKAAILACAAEYIQKLKETDEANIEKWTLQKLLSEQNASQLASANEKL 302

  Fly   591 MSRI----KELEMQ---AKSHGILLSENH 612
            ...:    ||:|..   .:..||...:.|
Yeast   303 QEELGNAYKEIEYMKRVLRKEGIEYEDMH 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	6/20 (30%)
		HLH	505..570	CDD:238036	26/70 (37%)
CBF1	NP_012594.1	HLH	220..272	CDD:238036	25/62 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810