Protein Alignment Mitf and RTG3

DIOPT Version :9

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_009447.1
• Gene: RTG3 / 852171
• SGDID: S000000199
• Length: 486
• Species: Saccharomyces cerevisiae
• Alignment Length: 586
• Identity: 135/586 - (23%)
• Similarity: 229/586 - (39%)
• Gaps: 163/586 - (27%)

  Fly   185 QLQREQQQQMMIQQQTLDTAM---------DPKMHLLFGSGQGLMESEFIDSGSTSACGSGSSSL 240
            :|..|...|..:.|:|||.::         |.|:|                   .||...|.:..
Yeast    13 RLLDELMNQTKVLQETLDFSLVTPTPHHNDDYKIH-------------------GSAYPGGETPA 58

  Fly   241 EQMSQLVQM--------DNLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKN 297
            :|..:|..:        :||:.|.:.:..:.|..|                   |.|...:.|.:
Yeast    59 QQHEKLSYINTHNSNDNNNLMGSQARSNSQTPTAS-------------------TIYEEAESQSS 104

  Fly   298 QVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIM 362
                ||.:.|:.|..|...::..:  :|...|.|: ||.......|::|............|..:
Yeast   105 ----YLDDMFRTSQGGRPVTQNSI--SSIGQGPLR-SSYSMAYDSPVDRAMNTPLQQQEGLKAEL 162

  Fly   363 P--------SDDAMPISPFGGSFVRCDDI-----NPIEPTVLRPNSHGAGEPENAHRTAQLGLSK 414
            |        :||.|        :...||:     :.|...::.||::.:....|..       |.
Yeast   163 PHDFLFQHGTDDTM--------YNLTDDLSSSLSSSINSDMMTPNTYSSSFSYNPQ-------SL 212

  Fly   415 ANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDK 479
            ..:|:|||.|.       ::.|.|||.::.|. :|.|...  .|::.|......|..|.:.|...
Yeast   213 GPASVSSTYSP-------KVRSPSSSFRAGSF-LSSSFRH--GSINTPRTRHTSISSNMTENIGP 267

  Fly   480 NFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEV 544
            .     |:.:....||..|     |.|:|::.||.:|||||..|..:|||||.|:|.....:.::
Yeast   268 G-----SVPKILGGLTSDE-----KLRRKREFHNAVERRRRELIKQKIKELGQLVPPSLLNYDDL 322

  Fly   545 VRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRK---LMSRIKELEMQAKSHGI 606
            .:.|:||||.||..:|:|::.|. |:            :|:|.||   |:::|||||.:..|
Yeast   323 GKQIKPNKGIILDRTVEYLQYLA-EI------------LEIQARKKKALLAKIKELEEKKSS--- 371

  Fly   607 LLSENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMEDC 671
                  :.:||    |:..:...|...:.|..|      |::|..|.... |..||:     ::.
Yeast   372 ------VAALS----PFTNNHHASSGQNNSENS------EERIIDIRSVP-NALMNE-----QNS 414

  Fly   672 KYAVQGGDPML----SSHSH---MQSAPQSPSSKTLNSGSFEPKNFSEADES---LFRGKSSLAS 726
            |..:...:|.|    .:|:|   |:|.|.:...:.|.  .|...:..||:::   :|...:|..:
Yeast   415 KAELHNWEPPLYDSVGNHNHAGTMESHPHTNIHEELK--EFLSGDLIEAEDNAKLMFGDDNSNPA 477

  Fly   727 D 727
            |
Yeast   478 D 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	6/38 (16%)
		HLH	505..570	CDD:238036	27/64 (42%)
RTG3	NP_009447.1	bHLHzip_USF_MITF	289..349	CDD:381393	26/72 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I2793
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		oto99383
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45776
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030