DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mitf and Usf1

DIOPT Version :9

Sequence 1:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_113965.1	Gene:	Usf1 / 83586	RGDID:	620974	Length:	310	Species:	Rattus norvegicus

Alignment Length:	256	Identity:	59/256 - (23%)
Similarity:	105/256 - (41%)	Gaps:	51/256 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 PSDDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSG 427
            |:..:|..:...|:|...|.::            ..|.....|.|.....:..:.|..:|   ||
  Rat    85 PATQSMTQAVIQGAFTSDDAVD------------AEGTAAETHYTYFPSTAVGDGSGGTT---SG 134

  Fly   428 IVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQ 492
            ...::..:..|.:|...:.|  ||.......:|.     .::||..|       ...::.:..|.
  Rat   135 STTAVVTTQGSEALLGQATP--PSTGQFFVMMSP-----QEVLQGGS-------QRSIAPRTHPY 185

  Fly   493 NLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILK 557
            : ..:|.....:|.:::..||.:|||||..||:.|.:|..::|   |...|..:. ..:||.||.
  Rat   186 S-PKSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIP---DCSMESTKS-GQSKGGILS 245

  Fly   558 SSVDYIKCLKHEVTRLRQ-----------NELRQRQVE-LQNRKLMSRIKELEMQAKSHGI 606
            .:.|||:.|:....||.:           |::.::||| |:|:.|:     |..|.:.||:
  Rat   246 KACDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLL-----LRAQLRHHGL 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	23/64 (36%)
Usf1	NP_113965.1	HLH	200..255	CDD:278439	21/58 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810