Protein Alignment Mitf and srebf1

DIOPT Version :9

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001098599.1
• Gene: srebf1 / 793274
• ZFINID: ZDB-GENE-090812-3
• Length: 1105
• Species: Danio rerio
• Alignment Length: 426
• Identity: 91/426 - (21%)
• Similarity: 161/426 - (37%)
• Gaps: 111/426 - (26%)

  Fly   262 KVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHT---------- 316
            :.||..  |:..|..||.:.....|.....:| ..:|.....|.|.:.:::.|:|
Zfish   118 QAPLAQ--VNSTPAALQTTQPKAQPAPSASLQ-PSSQTPPSASSSPQQTLYSSYTTHTTYTPVTQ 179

  Fly   317 --SEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVR 379
              |...:.:.|||..|:|..::|                 :|||..|:.:..:.|..|......:
Zfish   180 QSSPQSIPSLSASPQNIQPMTIQ-----------------SVSASPILTASSSPPTQPLPPQVQQ 227

  Fly   380 CDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQST 444
            .       |.:|:|.                 ..||:|.|.:|......:.:...|...::|.||
Zfish   228 L-------PVLLQPQ-----------------FIKADSLLLTTLKPDVTMVTTVASPCITTLTST 268

  Fly   445 SAPI--SP-----SVSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNAL 502
             ||:  :|     |..::.|:|.         |..|:.....|   .::|..:|        ...
Zfish   269 -APVQNTPLQALMSGGTILTTVP---------LVVDTEKLPIN---RIAISGKP--------GCQ 312

  Fly   503 AKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLK 567
            ....:|:..||.||:|.|.:|||:|.||..|: .|::|        :.||..:||.:::||:.|:
Zfish   313 PHKGEKRTAHNAIEKRYRSSINDKIIELKDLV-AGTEA--------KLNKSAVLKKAIEYIRYLQ 368

  Fly   568 HEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLSENHLTSLSAPTQPYL---KSFSL 629
            ....:|:|..:..: :.:|..|.:..:..:|:..|.             ..||.|..   ...|.
Zfish   369 QSNQKLKQENMALK-MNIQKNKSLKDLVTMEVDVKP-------------EIPTPPASDVGSPQSS 419

  Fly   630 SPTASRSRRSLFDQPV-EKKIQVIDGADGNMGMNQV 664
            .|.:..|..|..|.|: |....|::.|.|.:..:::
Zfish   420 GPYSQHSSDSEPDSPMAEDSKAVVERAGGMLDRSRM 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	8/38 (21%)
		HLH	505..570	CDD:238036	23/64 (36%)
srebf1	NP_001098599.1	helix-Loop-helix DNA binding domain	315..372		23/65 (35%)
		HLH	315..372	CDD:238036	23/65 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940