DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mitf and USF1

DIOPT Version :9

Sequence 1:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001263302.1	Gene:	USF1 / 7391	HGNCID:	12593	Length:	310	Species:	Homo sapiens

Alignment Length:	256	Identity:	60/256 - (23%)
Similarity:	104/256 - (40%)	Gaps:	51/256 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 PSDDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSG 427
            |:..:|..:...|:|. .||....|.|.  ..:|....|..|......|            ::||
Human    85 PATQSMTQAVIQGAFT-SDDAVDTEGTA--AETHYTYFPSTAVGDGAGG------------TTSG 134

  Fly   428 IVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQ 492
            ...::..:..|.:|...:.|  |........:|.     .::||..|       ...::.:..|.
Human   135 STAAVVTTQGSEALLGQATP--PGTGQFFVMMSP-----QEVLQGGS-------QRSIAPRTHPY 185

  Fly   493 NLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILK 557
            : ..:|.....:|.:::..||.:|||||..||:.|.:|..::|   |...|..:. ..:||.||.
Human   186 S-PKSEAPRTTRDEKRRAQHNEVERRRRDKINNWIVQLSKIIP---DCSMESTKS-GQSKGGILS 245

  Fly   558 SSVDYIKCLKHEVTRLRQ-----------NELRQRQVE-LQNRKLMSRIKELEMQAKSHGI 606
            .:.|||:.|:....||.:           |::.::||| |:|:.|:     |..|.:.||:
Human   246 KACDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLL-----LRAQLRHHGL 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	23/64 (36%)
USF1	NP_001263302.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..209		7/45 (16%)
		bHLHzip_USF1	196..260	CDD:381494	23/67 (34%)
		Leucine-zipper	271..292		7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810