Protein Alignment Mitf and SREBF2

DIOPT Version :9

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_004590.2
• Gene: SREBF2 / 6721
• HGNCID: 11290
• Length: 1141
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 108/534 - (20%)
• Similarity: 196/534 - (36%)
• Gaps: 171/534 - (32%)

  Fly   214 GSGQGLMESEFIDSGSTSACGSGSS------SLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGV-- 270
            |||.....|....|.|:|:.|.|||      |:::....|.:.:.  |.|.|..:.|...:.|
Human    56 GSGGSGSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSF--SPSAASPQAPTLQVKVSP 118

  Fly   271 -DVP------------------PQV-LQVSTVLENPT-----RYHVIQKQKNQVRQYLSESF--- 307
             .||                  ||. ||..||:..||     :..:||:.  .:.|..:.||
Human   119 TSVPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQP--LIYQNAATSFQVL 181

  Fly   308 KPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIM---PSDDAMP 369
            :|.:....||           ..:|..::|:.:             ..|.|:|::   .:.....
Human   182 QPQVQSLVTS-----------SQVQPVTIQQQV-------------QTVQAQRVLTQTANGTLQT 222

  Fly   370 ISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIRI 434
            ::|.....|....:..: |.:::|.                 :.|.:|.:.:|..:.|  :.:..
Human   223 LAPATVQTVAAPQVQQV-PVLVQPQ-----------------IIKTDSLVLTTLKTDG--SPVMA 267

  Fly   435 SSTSSSLQSTSAPISPSVSSVATSVSEPDDIFD--DILQNDSFNFDKNFNSELSIKQEPQNLTDA 497
            :..:.:|.:.:.||..:...|.|.|.....|..  .::..         ..::.|||.|..:...
Human   268 AVQNPALTALTTPIQTAALQVPTLVGSSGTILTTMPVMMG---------QEKVPIKQVPGGVKQL 323

  Fly   498 EMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDY 562
            |.   .|:.:::..||:||:|.|.:|||:|.||..|: .|:||        :.:|..:|:.::||
Human   324 EP---PKEGERRTTHNIIEKRYRSSINDKIIELKDLV-MGTDA--------KMHKSGVLRKAIDY 376

  Fly   563 IKCLKHEVTRLRQNELRQRQVELQNRK-----------LMSRIKELEMQAKSHGILLSENHLTSL 616
            ||.|:....:|||..:   .::|.|:|           |:....:|:::..:..:||
Human   377 IKYLQQVNHKLRQENM---VLKLANQKNKLLKGIDLGSLVDNEVDLKIEDFNQNVLL-------- 430

  Fly   617 SAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMEDCKYAVQGGDPM 681
                        :||.||.|                 |:........:|.         :.|.|:
Human   431 ------------MSPPASDS-----------------GSQAGFSPYSIDS---------EPGSPL 457

  Fly   682 LSSHSHMQSAPQSP 695
            |.. :.::..|.||
Human   458 LDD-AKVKDEPDSP 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	16/65 (25%)
		HLH	505..570	CDD:238036	23/64 (36%)
SREBF2	NP_004590.2	Transcriptional activation (acidic). /evidence=ECO:0000250|UniProtKB:P36956	1..50
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..144		22/89 (25%)
		Interaction with LMNA. /evidence=ECO:0000250|UniProtKB:Q3U1N2	237..491		65/325 (20%)
		HLH	331..381	CDD:278439	22/58 (38%)
		Leucine-zipper	380..401		6/23 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940