Protein Alignment Mitf and tfe3b

DIOPT Version :10

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001038531.1
• Gene: tfe3b / 564996
• ZFINID: ZDB-GENE-010919-3
• Length: 451
• Species: Danio rerio
• Alignment Length: 615
• Identity: 167/615 - (27%)
• Similarity: 227/615 - (36%)
• Gaps: 253/615 - (41%)

  Fly   177 TSRTQLKLQLQREQ---QQQMMIQQQTLDTAMDPKMHLLFGSGQGLMESEFIDSGSTSACGSGSS 238
            :||..|:.||.|||   |::...|||.....:.|                   :.:|.|.   |.
Zfish     2 SSRVLLRQQLMREQAQEQERREAQQQASVAQLRP-------------------ADTTPAI---SV 44

  Fly   239 SLEQMSQLVQMDNLIDSSSGAKLKVPLQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYL 303
            ||..|               |....|.|     ||.:||:|.|.|||||:||:.|.|:.||::||
Zfish    45 SLPPM---------------AARPPPAQ-----VPVEVLKVQTHLENPTKYHIQQAQRQQVKEYL 89

  Fly   304 SESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAM 368
            |.:.               .|..:|..|
Zfish    90 STTL---------------GNKVATQTL------------------------------------- 102

  Fly   369 PISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIR 433
                         .::|:        .|.|..||       :|.|
Zfish   103 -------------GVSPV--------PHSASAPE-------MGPS-------------------- 119

  Fly   434 ISSTSSSLQSTSAPISPSVS-SVATSVSEPDDIFDDILQ-NDSFNFD--KNFNSELSIKQE-PQN 493
                     ::|||.||... ::.::..|.||:.|||:. ..|||.|  ...:|.|.:... |.|
Zfish   120 ---------ASSAPNSPMAHLNLGSNKEEMDDVIDDIISLESSFNDDILSLIDSGLQLPNTLPGN 175

  Fly   494 LTD-------------------------------------AEMNALAKDRQKKDNHNMIERRRRF 521
            |.|                                     .|..|..|:||||||||:|||||||
Zfish   176 LLDVYNSPGMTTPTITVSNSCPADLPNIKREYTGNVIVIETEARAFMKERQKKDNHNLIERRRRF 240

  Fly   522 NINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQ 586
            ||||||||||.|:||.:|.      ::|.|||||||:|||||:.|:.|..|.::.|:||:::|..
Zfish   241 NINDRIKELGALIPKSTDP------EMRWNKGTILKASVDYIRKLQKEQQRAKEIEMRQKKLEQS 299

  Fly   587 NRKLMSRIKELEMQAKSHGILLSENHLTSLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQV 651
            |:.|:.||:|||:||:.||          |:|...|     .|:..||..:..|.......:..|
Zfish   300 NQALILRIQELEIQARHHG----------LNATVSP-----GLNTEASFIQNQLLQPNASMQAGV 349

  Fly   652 IDG-------ADGNMGMNQVDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSSKTLN-SG--SFE 706
            .||       .||.|.......|:                     |.|.|.|...:. ||  ..|
Zfish   350 GDGQPQSHLNMDGAMAQTSPSPFL---------------------SVPPSGSPAAVAVSGPLHLE 393

  Fly   707 PKNFSEADE---SLFR--GKSSLASDDCCG 731
            ..:|:|.||   .|:.  |.|.:..||..|
Zfish   394 TFSFTELDEHASDLYPDVGLSDILMDDVRG 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	20/38 (53%)
		bHLHzip_MITF_like	504..577	CDD:381403	46/72 (64%)
tfe3b	NP_001038531.1	MITF_TFEB_C_3_N	4..145	CDD:464952	59/291 (20%)
		bHLH_SF	217..307	CDD:469605	54/95 (57%)
		DUF3371	312..450	CDD:463372	35/148 (24%)