Protein Alignment Mitf and SREBP

DIOPT Version :9

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001262064.1
• Gene: SREBP / 40155
• FlyBaseID: FBgn0261283
• Length: 1113
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 104/484 - (21%)
• Similarity: 174/484 - (35%)
• Gaps: 151/484 - (31%)

  Fly   270 VDVPPQVLQVSTVLENPTRYHVIQKQK-NQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQN 333
            :|:.|  .|:..:|.:..|.|..|.|. :|..|.:.:  :|.:...|:|.:.:......  ..|.
  Fly    45 MDLAP--TQMYNMLLDEPRTHTQQTQSVDQQPQSVEQ--QPHVKSEHSSPVHIKEELHQ--QQQQ 103

  Fly   334 SSLQKGICDPLERTNRFGCDSA-----------------VSAKRIMPSDDAMPISPFGGSFV--- 378
            |.|.....|||..|: :.|...                 :.|:|:.|:....|.| .|.|||
  Fly   104 SPLLVYKPDPLIATS-YNCPQQQPTGLLKAAQPTATIHHMDAQRMPPNTAVYPPS-LGSSFVYQS 166

  Fly   379 ----------RCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIR 433
                      ...::|.::|....|....|..|:.::....:..: :.:.::|..:...::....
  Fly   167 MSPPTSPVESANQNVNVMQPVAATPAPASAPLPQQSYPQPFITYN-SKAGMTSDEAMYFLLQPTV 230

  Fly   434 ISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQNLTDAE 498
            .|.|      .|.|::|..:|..:..|:                         ::..|...:.|.
  Fly   231 ASPT------PSPPVAPPPTSTGSRASK-------------------------VRVAPLAPSPAA 264

  Fly   499 MNALAK----------DRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKG 553
            |....|          ...|:..||.||||.|.:|||:|.||..|:         |....:.||.
  Fly   265 MEVQGKVPINRVQPKVKEVKRSAHNAIERRYRTSINDKINELKNLV---------VGEQAKLNKS 320

  Fly   554 TILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLM----SRIKELEMQAKSHGILLSENHLT 614
            .:|:.|:|.|:.|:      |||...:.:::...|:||    |::|:|
  Fly   321 AVLRKSIDKIRDLQ------RQNHDLKAELQRLQRELMARDGSKVKDL----------------- 362

  Fly   615 SLSAPTQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGADGNMGMNQVDEFMEDCKYAVQGGD 679
             |...|:|        ..||:.||        :..|... .|..:...:.||           .|
  Fly   363 -LQLGTRP--------GRASKKRR--------ESSQTFT-TDAGLTPPRSDE-----------SD 398

  Fly   680 PMLS-SHSHMQSAPQSP---SSKTLNSGS 704
            |.|| .||.: |.|.||   |:.:.:|||
  Fly   399 PSLSPMHSDI-SLPPSPYGGSTASCSSGS 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	10/39 (26%)
		HLH	505..570	CDD:238036	23/64 (36%)
SREBP	NP_001262064.1	HLH	281..338	CDD:238036	25/71 (35%)
		OmpH	<289..>364	CDD:281871	30/107 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940