DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mitf and usf1

DIOPT Version :9

Sequence 1:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_956590.1	Gene:	usf1 / 393266	ZFINID:	ZDB-GENE-040426-1072	Length:	309	Species:	Danio rerio

Alignment Length:	379	Identity:	75/379 - (19%)
Similarity:	128/379 - (33%)	Gaps:	130/379 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 DVPPQVLQVSTV--LENPTRYHVIQK----QKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTG 329
            ||...|::...|  .|:|:....||.    ..:|..:||   ||....|....|:
Zfish    11 DVSVPVIEEGAVATAEDPSAITTIQSASTFSTDQPIKYL---FKTEGAGGQVGEL---------- 62

  Fly   330 NLQNSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRC-----DDINPIEPT 389
                                :.....|:.:.|..:|..:...|.|.:.|..     ....|:...
Zfish    63 --------------------YPPSGQVTYRVIQVADGQLEAQPDGTTAVSVVTGFPATTQPVTQA 107

  Fly   390 VLRPNSHGAGEPENAHRT---AQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPS 451
            |...:....|:....|.|   |.:..:.|.:.::..::             |.:|.:.|||.
Zfish   108 VFSQSEGLEGDGTETHYTYYPATISDATAGTMVTGVQA-------------SDALLTQSAPA--- 156

  Fly   452 VSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQN-LTDAEMNALA------------ 503
                                           .:|.:...||. ||.|...::|
Zfish   157 -------------------------------GQLYVMMSPQEVLTGANQRSIAPRTQAYNAKSEG 190

  Fly   504 ----KDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIK 564
                :|.:::..||.:|||||..||:.|.:|...:|   |...:..: ...:||.||..:.|||:
Zfish   191 PRTSRDEKRRAQHNEVERRRRDKINNWIVQLSKTIP---DCTIDSTK-TGQSKGGILSKACDYIQ 251

  Fly   565 CLK----------HEVTRLR-QNELRQRQVELQNRKLMSRIKELEMQAKSHGIL 607
            .|:          :.:.||| .|:|.:::||    ...|:.:.|..|.:.|||:
Zfish   252 ELRQSNSRLGDELNSIERLRMDNQLLRQEVE----DWKSKNQILRNQLRQHGIV 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	12/44 (27%)
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	22/74 (30%)
usf1	NP_956590.1	HLH	199..254	CDD:278439	20/58 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840