DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mitf and Tfeb

DIOPT Version :9

Sequence 1:NP_001245436.1 Gene:Mitf / 3885647 FlyBaseID:FBgn0263112 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_001020878.1 Gene:Tfeb / 316214 RGDID:1309583 Length:535 Species:Rattus norvegicus


Alignment Length:570 Identity:165/570 - (28%)
Similarity:230/570 - (40%) Gaps:185/570 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 PLSGGPTFK---------------------TATPTSRTQLKLQLQREQQQQ----MMIQQQTLDT 203
            |..|.||.|                     ||...||..|::||.|||.||    ..:|||.:  
  Rat    27 PYLGQPTLKDSEDDEYFMDLSSLDCREPESTAAMASRIGLRMQLMREQAQQEEQRERMQQQAV-- 89

  Fly   204 AMDPKMHLLFGSGQGLMESEFIDSGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGA-KLKVPLQS 267
                 ||.:                             |..|..|...|....:.| ...|..||
  Rat    90 -----MHYM-----------------------------QQQQQQQQQQLGGPPTPAINTPVHFQS 120

  Fly   268 IGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQ 332
             ...||.:||:|.:.|||||.||:.|.|..:||:||||::                         
  Rat   121 -PPPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETY------------------------- 159

  Fly   333 NSSLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNS-- 395
                          .|:|       |..:.|:..:....|.....||...:.........|||  
  Rat   160 --------------GNKF-------AAHVSPAQGSPKPPPAASPGVRAGHVLSTSAGNSAPNSPM 203

  Fly   396 ---HGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVAT 457
               |.:..||.........:.:.:|.|........:.|::.:||:..::.|....::.|:..| |
  Rat   204 AMLHISSNPEKEFDDVIDNIMRLDSVLGYINPEMQMPNTLPLSSSHLNVYSGDPQVTASLVGV-T 267

  Fly   458 SVSEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFN 522
            |.|.|.|                    |:.|:|   |||||..||||:||||||||:||||||||
  Rat   268 SSSCPAD--------------------LTQKRE---LTDAESRALAKERQKKDNHNLIERRRRFN 309

  Fly   523 INDRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQN 587
            |||||||||.|:||.:|.      |:|.|||||||:|||||:.::.::.:.|:.|...|::|:.|
  Rat   310 INDRIKELGMLIPKANDL------DVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTN 368

  Fly   588 RKLMSRIKELEMQAKSHGILLSENHLTSLSAPTQPYLKSFSLSPTASRS---RRSLFDQPVEKKI 649
            ::|..||:||||||:.||:                        ||.|.|   ...|..|.|::::
  Rat   369 KQLWLRIQELEMQARVHGL------------------------PTTSPSGVNMAELAQQVVKQEL 409

  Fly   650 QVIDGADGNMGMNQVDEFMEDCKYAVQGGDPM--LSSHSHMQSA--PQSP 695
            ...|.....:.:..          .|...:||  |...:.:.||  ||||
  Rat   410 PSEDNPGETLMLGS----------EVPDPEPMPALPPQAPLPSAAQPQSP 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MitfNP_001245436.1 MITF_TFEB_C_3_N <272..>311 CDD:292573 20/38 (53%)
HLH 505..570 CDD:238036 43/64 (67%)
TfebNP_001020878.1 MITF_TFEB_C_3_N 63..220 CDD:292573 55/239 (23%)
HLH 292..352 CDD:238036 43/65 (66%)
DUF3371 380..516 CDD:288684 23/104 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351577
Domainoid 1 1.000 85 1.000 Domainoid score I7983
eggNOG 1 0.900 - - E1_KOG1318
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 191 1.000 Inparanoid score I3781
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1211990at2759
OrthoFinder 1 1.000 - - FOG0000691
OrthoInspector 1 1.000 - - otm45098
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45776
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X566
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.860

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