DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mitf and Tfec

DIOPT Version :9

Sequence 1:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_071774.1	Gene:	Tfec / 26296	RGDID:	3846	Length:	317	Species:	Rattus norvegicus

Alignment Length:	378	Identity:	128/378 - (33%)
Similarity:	175/378 - (46%)	Gaps:	109/378 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 KRIMP-SDDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSST 422
            ||..| :...||::..|          |..|.   .::..||.|    .|..|.|.|
  Rat    13 KRAQPLAASCMPLAEHG----------PRSPD---SDAGCAGNP----FTNPLALGK-------- 52

  Fly   423 RSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSI 487
              ..|:| ..|:|.:...:.|....||| |::...:.|.|                    |.|.:
  Rat    53 --EDGVV-EWRLSGSILDVYSGEQGISP-VNTGLMNASCP--------------------SILPM 93

  Fly   488 KQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNK 552
            |:|   :.:.:..||||:||||||||:||||||:|||.||||||||:||.:|.      |||.||
  Rat    94 KKE---IAETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDP------DIRWNK 149

  Fly   553 GTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHG--ILLS------ 609
            |||||:||||||.|:.|..|.|:.|.||:::|..||:||.||:|||:||::||  ||.|
  Rat   150 GTILKASVDYIKWLQKEQQRARELEHRQKKLEHANRQLMLRIQELEIQARAHGLPILASLGTADF 214

  Fly   610 ENHLTSLSAPTQPYLKSFS------LSPTASRS-----RRSLFDQPVE-----------KKIQVI 652
            ..|:|.    .|.:.:..|      |:|:...|     :...|..|:.           |:.|.:
  Rat   215 GTHITK----QQTHSEKNSVGCCQQLTPSQGTSPEFYEQAVAFSDPLSHFTDLSFSAALKEEQRL 275

  Fly   653 DGADGNMGMNQVDEFMED--CKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSG 703
            ||.           .:.|  |.:   |.||:||:.|...|...|.||.:...|
  Rat   276 DGM-----------LLSDTICPF---GTDPLLSAISPAVSKASSRSSLSSEDG 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	45/64 (70%)
Tfec	NP_071774.1	Necessary for transcriptional transactivation. /evidence=ECO:0000250	1..90		26/125 (21%)
		HLH	108..168	CDD:238036	46/65 (71%)
		DUF3371	196..300	CDD:288684	28/121 (23%)
		Necessary for transcriptional transactivation. /evidence=ECO:0000250	242..317		20/87 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351579
Domainoid	1	1.000	85	1.000	Domainoid score	I7983
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3781
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		otm45098
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45776
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.000