DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mitf and sre1

DIOPT Version :9

Sequence 1:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_595694.1	Gene:	sre1 / 2540730	PomBaseID:	SPBC19C2.09	Length:	900	Species:	Schizosaccharomyces pombe

Alignment Length:	790	Identity:	157/790 - (19%)
Similarity:	251/790 - (31%)	Gaps:	305/790 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 LQSIGVDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANN---SA 326
            :.|:.|.|      .|..:|.||:.....|..|.|             |:..|...||::   |.
pombe     5 IPSVSVSV------ASPAMETPTKASPDSKSPNSV-------------GAIPSSSPLASSTKAST 50

  Fly   327 STGNLQNSSLQKGICD--------PLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDI 383
            ||..::|.|  ..:||        |...||     :::|......||....:|.:...|...:.:
pombe    51 STPFVENCS--NLLCDLASIVEDSPPTLTN-----TSLSPHSFSLSDMESSMSNWLNPFAFDNTM 108

  Fly   384 NPIEPTVLRPNSHGAGEPENAHRTAQLGLSKANSSLSST---------------RSSSGIVNSIR 433
            |...|.....|.......||:...........||..:.|               :....|::|:.
pombe   109 NSAPPLFTSTNMGSPNSLENSTNPLLSNCGSPNSFQNETFTGPSLNEFDADDKIQRQMKILHSVD 173

  Fly   434 ISSTSSSLQSTSAPIS----------------------PSVSSVATSVSEPDDIFDDILQNDSFN 476
            ....|:.....||.:|                      ||...:..|.|..|..  .|.:...|:
pombe   174 TIDPSTVQNYPSADMSNPEVKLKTEEIITPMDTTCKPEPSAKKIKLSPSSEDSC--SIPETLPFS 236

  Fly   477 FDKNFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPK----- 536
            ..|:..| ||..:.|      :..|....:.||..|||||:|.|.|:||||.||...:|.
pombe   237 APKSRGS-LSPSETP------DFVAGPGGKPKKTAHNMIEKRYRTNLNDRICELRDAVPSLRAAA 294

  Fly   537 ----GSDAFYEVVRDIRP----NKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSR 593
                |:....|.:..:.|    ||||||..:.:||:.|          |.:.::::..|::|..|
pombe   295 ALRCGNSLDDEDLGGLTPARKLNKGTILAKATEYIRHL----------EAKNKELQKTNKQLSDR 349

  Fly   594 IKELE-----------MQAKSHGILLSENHLTSLSAPTQPYL--KSFSLSPTASRSRRSLFDQPV 645
            :...|           ....|..::.|.::  |:...::|.|  ::|: |||.:...|:
pombe   350 LAFYEDPSMAPPSNDTRAVNSVNVVSSSDY--SVHQSSRPNLTQRAFT-SPTLNTMGRT------ 405

  Fly   646 EKKIQVIDGADGNMGMNQVDEFMEDCKYAVQGGDPMLSSHSHMQSAP---QSPSSKTL--NS--- 702
                    ..:|.:|:...:.|..|...:|.|          :.:.|   .||.:.|:  |.
pombe   406 --------ALNGMVGLGLFNYFGNDSSQSVYG----------LFALPPFLMSPFTGTVLFNMLKI 452

  Fly   703 -----GSFEPKNFSEADESLFRG-----------KSSLAS----------DDCCGINCSTSC--- 738
                 |.|    :...|.|||:|           :||::.          :..|.::.|||.
pombe   453 GVVLLGLF----YLLHDNSLFKGFKGEKKSKVSTRSSMSPSSILFRKTVFEKYCLLDHSTSTISL 513

  Fly   739 --------------YIQHQL----TSREGH----------------------------------- 750
                          |:.|:|    ||.|..
pombe   514 FFGLLIFTLKSAYGYLTHRLSALYTSSENWVYSEQQLAEVRNMEKLLDAQLMGGDAKVDRLRLLM 578

  Fly   751 --------PNHSHHTGIREIH----------------------------SLSDSAQNSEFSRLEH 779
                    |..||...::.::                            ..|.|:.::|...|..
pombe   579 VFASSFSLPPSSHTCALQAMYCQLIFSNTSVPSAIVSKCVAFFWNAAKKQHSKSSVHAELRELPE 643

  Fly   780 CDDPLLSSSHRSLGTVDEDQHNSVDM----------SAVMVHDSLSSLVDDNNSETMVL------ 828
            |...|:.:||..    |....|.|:.          ||.|....:|||     |:.:||
pombe   644 CTANLIENSHAD----DVFSPNMVERLWVLAKCTRDSAQMSDSIISSL-----SDVLVLSPLEVL 699

  Fly   829 ----ASDTLD 834
                |:|.||
pombe   700 ASWYAADLLD 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	8/38 (21%)
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	29/77 (38%)
sre1	NP_595694.1	HLH	261..333	CDD:278439	29/81 (36%)
sre1	NP_595694.1	DUF2014	517..766	CDD:286510	33/202 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	44	1.000	Domainoid score	I3632
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030