Protein Alignment Mitf and Mitf

DIOPT Version :10

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001178018.1
• Gene: Mitf / 25094
• RGDID: 3092
• Length: 526
• Species: Rattus norvegicus
• Alignment Length: 624
• Identity: 178/624 - (28%)
• Similarity: 249/624 - (39%)
• Gaps: 225/624 - (36%)

  Fly   154 TAEPRIVGLPPLSGGPTFKTATPTSRTQLKLQLQRE--QQQQMMIQQQTLDTAMDPKMHLLFGSG 216
            :||......||||      ::|.|||..|:.||.||  |:|:...|||.|
  Rat    37 SAEHSGASKPPLS------SSTMTSRILLRQQLMREQMQEQERREQQQKL--------------- 80

  Fly   217 QGLMESEFIDSGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGAKLKVP--LQSIGVDVPPQVLQV 279
                                     |.:|.:|....:..:....:.||  |.| ...||.:||:|
  Rat    81 -------------------------QAAQFMQQRVAVSQTPAINVSVPTTLPS-ATQVPMEVLKV 119

  Fly   280 STVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKGICDPL 344
            .|.|||||:||:.|.|::||:||||.:              |||..|..           :..|
  Rat   120 QTHLENPTKYHIQQAQRHQVKQYLSTT--------------LANKHAGQ-----------VLSP- 158

  Fly   345 ERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNSHGAGEPENAHRTAQ 409
                  .|.:       .|.|.|||..|
  Rat   159 ------PCPN-------QPGDHAMPPVP------------------------------------- 173

  Fly   410 LGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVA-TSVSEPDDIFDDILQND 473
             |.|..||.::....:|   |..:.:......||.:....|.:::.: .|..:.||:.|||:
  Rat   174 -GSSAPNSPMAMLTLNS---NCEKEAFYKFEEQSRAESECPGMNTHSRASCMQMDDVIDDII--- 231

  Fly   474 SFNFDKNFNSE----------------------------------LSIKQE-PQNL--------- 494
              :.:.::|.|                                  |:|... |.||
  Rat   232 --SLESSYNEEILGLMDPALQMANTLPVSGNLIDLYSNQGLPPPGLTISNSCPANLPNIKRELTA 294

  Fly   495 ----TDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKGTI 555
                |::|..||||:||||||||:|||||||||||||||||||:||.:|.      |:|.|||||
  Rat   295 CIFPTESEARALAKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSNDP------DMRWNKGTI 353

  Fly   556 LKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGILLSENHLTSLSAP- 619
            ||:|||||:.|:.|..|.:..|.||:::|..||.|:.|::||||||::||:.|..:  |.|.:|
  Rat   354 LKASVDYIRKLQREQQRAKDLENRQKKLEHANRHLLLRVQELEMQARAHGLSLIPS--TGLCSPD 416

  Fly   620 -------TQPYLKSFSLSPTASRSRRSLFDQPVEKKIQVIDGA---DGNMG-------------- 660
                   .:|.|::.|......::     |......:.:.||.   ..|:|
  Rat   417 LVNRIIKQEPVLENCSQELVQHQA-----DLTCTTTLDLTDGTISFTNNLGTMPESSPAYSIPRK 476

  Fly   661 --MNQVDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSS 697
              .|..|..|:|....|...||:|||.|...|...|..|
  Rat   477 MASNLEDILMDDALSPVGVTDPLLSSVSPGASKTSSRRS 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:464952	21/38 (55%)
		bHLHzip_MITF_like	504..577	CDD:381403	48/72 (67%)
Mitf	NP_001178018.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..54		6/16 (38%)
		MITF_TFEB_C_3_N	56..194	CDD:464952	43/141 (30%)
		bHLHzip_MITF	300..403	CDD:381496	37/151 (25%)
		Leucine-zipper. /evidence=ECO:0000305	374..395		14/33 (42%)
		DUF3371	397..522	CDD:463372	62/132 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..526		6/37 (16%)