DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mitf and TFEC

DIOPT Version :9

Sequence 1:NP_001245436.1 Gene:Mitf / 3885647 FlyBaseID:FBgn0263112 Length:837 Species:Drosophila melanogaster
Sequence 2:XP_011514265.1 Gene:TFEC / 22797 HGNCID:11754 Length:437 Species:Homo sapiens


Alignment Length:526 Identity:149/526 - (28%)
Similarity:230/526 - (43%) Gaps:166/526 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   276 VLQVSTVLENPTRYHVIQKQKN-QVRQYLSE---------SFK----------PSMWGSHTSEIK 320
            :||..|.|:...:..:.:|::. |:.|.:|.         |:|          |.::.|     :
Human     1 MLQALTGLQFQLKEQLGEKERRLQISQEISAHRTEFHMQFSYKPVLHRLVPARPQIYSS-----Q 60

  Fly   321 LANNSASTGNLQNSS---LQKGICDPLERTNRFGCDSAVSAKRIMPS-DDAMPISPFGGSFVRCD 381
            |.:.:....:|::|:   |||.   ..::.|.|   ..:..:.|.|: ..:.|..|.||..|:  
Human    61 LPSFTRVPAHLESSARPQLQKA---QRQKVNSF---MTLDHQIINPTLKWSQPAVPSGGPLVQ-- 117

  Fly   382 DINPIEPTVLRPNSH-----GAGEPENAHRTAQLGLSKAN------------------SSLSSTR 423
                        ::|     .||..||. .|..|.:.|.:                  ||.....
Human   118 ------------HAHTTLDSDAGLTENP-LTKLLAIGKEDDNAQWHMEDVIEDIIGMESSFKEEG 169

  Fly   424 SSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFDDILQNDSFNFDKNFNSELSIK 488
            :.|.::....:|.:...:.|....||| ::...||.|.|                    |.|.:|
Human   170 ADSPLLMQRTLSGSILDVYSGEQGISP-INMGLTSASCP--------------------SSLPMK 213

  Fly   489 QEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGTLLPKGSDAFYEVVRDIRPNKG 553
            :|   :|:.:..||||:||||||||:||||||:|||.||||||||:||.:|.      |:|.|||
Human   214 RE---ITETDTRALAKERQKKDNHNLIERRRRYNINYRIKELGTLIPKSNDP------DMRWNKG 269

  Fly   554 TILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKELEMQAKSHGI--LLSEN----- 611
            ||||:||:|||.|:.|..|.|:.|.||:::|..||:|:.||:|||:||::||:  |.|..     
Human   270 TILKASVEYIKWLQKEQQRARELEHRQKKLEQANRRLLLRIQELEIQARTHGLPTLASLGTVDLG 334

  Fly   612 -HLT-SLSAPTQ---PYLKSFSLS--PTASRSRRSL-FDQPVE-----------KKIQVIDGADG 657
             |:| ..|.|.|   .|.:..::|  |:.....::: |..|:.           |:.|.:||   
Human   335 AHVTKQQSHPEQNSVDYCQQLTVSQGPSPELCDQAIAFSDPLSYFTDLSFSAALKEEQRLDG--- 396

  Fly   658 NMGMNQVDEFMEDCKYAVQGGDPMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADESLFRGKS 722
                     .:.|...:..|.||:||:.|   .|....||:                      :|
Human   397 ---------MLLDDTISPFGTDPLLSATS---PAVSKESSR----------------------RS 427

  Fly   723 SLASDD 728
            |.:|||
Human   428 SFSSDD 433

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MitfNP_001245436.1 MITF_TFEB_C_3_N <272..>311 CDD:292573 11/54 (20%)
HLH 505..570 CDD:238036 43/64 (67%)
TFECXP_011514265.1 MITF_TFEB_C_3_N 6..155 CDD:292573 33/174 (19%)
HLH 227..287 CDD:238036 44/65 (68%)
DUF3371 315..434 CDD:288684 35/156 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157593
Domainoid 1 1.000 85 1.000 Domainoid score I8159
eggNOG 1 0.900 - - E1_KOG1318
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 164 1.000 Inparanoid score I4199
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1211990at2759
OrthoFinder 1 1.000 - - FOG0000691
OrthoInspector 1 1.000 - - otm40964
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45776
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X566
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.860

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