Protein Alignment Mitf and Tfeb

DIOPT Version :9

• Sequence 1: NP_001245436.1
• Gene: Mitf / 3885647
• FlyBaseID: FBgn0263112
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_035679.3
• Gene: Tfeb / 21425
• MGIID: 103270
• Length: 534
• Species: Mus musculus
• Alignment Length: 567
• Identity: 168/567 - (29%)
• Similarity: 236/567 - (41%)
• Gaps: 169/567 - (29%)

  Fly   146 LGDISIDETAEPRIVGLPPLSGGPTFKTATPTSRTQLKLQLQREQQQQ----MMIQQQTLDTAMD 206
            |.|...||    ..:||.||.......||...||..|::||.|||.||    ..:|||.:
Mouse    34 LKDYEDDE----YFMGLSPLDYREPEPTAAMASRIGLRMQLMREQAQQEEQRERMQQQAV----- 89

  Fly   207 PKMHLLFGSGQGLMESEFIDSGSTSACGSGSSSLEQMSQLVQMDNLIDSSSGAKLKVPL--QSIG 269
              ||                               .|.|..|....:.......:..|:  || .
Mouse    90 --MH-------------------------------YMQQQQQQQQQLGGPPTPAINTPVHFQS-P 120

  Fly   270 VDVPPQVLQVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNS 334
            ..||.:||:|.:.|||||.||:.|.|..:||:||||::
Mouse   121 PPVPGEVLKVQSYLENPTSYHLQQSQHQKVREYLSETY--------------------------- 158

  Fly   335 SLQKGICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVLRPNS---- 395
                        .|:|       |..:.|:..:...:|.....||...:.........|||
Mouse   159 ------------GNKF-------AAHVSPAQGSPKPAPAASPGVRAGHVLSTSAGNSAPNSPMAM 204

  Fly   396 -HGAGEPENAHRTAQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSV 459
             |.:..||.........:.:.:|.|........:.|::.:||:..::.|....::.|:..| ||.
Mouse   205 LHISSNPEKEFDDVIDNIMRLDSVLGYINPEMQMPNTLPLSSSHLNVYSGDPQVTASMVGV-TSS 268

  Fly   460 SEPDDIFDDILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNIN 524
            |.|.|                    |:.|:|   |||||..||||:||||||||:||||||||||
Mouse   269 SCPAD--------------------LTQKRE---LTDAESRALAKERQKKDNHNLIERRRRFNIN 310

  Fly   525 DRIKELGTLLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRK 589
            |||||||.|:||.:|.      |:|.|||||||:|||||:.::.::.:.|:.|...|::|:.|::
Mouse   311 DRIKELGMLIPKANDL------DVRWNKGTILKASVDYIRRMQKDLQKSRELENHSRRLEMTNKQ 369

  Fly   590 LMSRIKELEMQAKSHGILLSENHLTSLSAPTQPYLKSFSLSPTASRS---RRSLFDQPVEKKIQV 651
            |..||:||||||:.||:                        ||.|.|   ...|..|.|::::..
Mouse   370 LWLRIQELEMQARVHGL------------------------PTTSPSGVNMAELAQQVVKQELPS 410

  Fly   652 IDG-ADGNMGMNQVDEFMEDCKYAVQGGDPMLSSHSHMQSA--PQSP 695
            .|| .:..|...:|.|..:         .|.|...:.:.||  ||||
Mouse   411 EDGPGEALMLGPEVPEPEQ---------MPALPPQAPLPSAAQPQSP 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	20/38 (53%)
		HLH	505..570	CDD:238036	43/64 (67%)
Tfeb	NP_035679.3	MITF_TFEB_C_3_N	63..219	CDD:292573	53/240 (22%)
		HLH	291..351	CDD:238036	43/65 (66%)
		DUF3371	379..531	CDD:288684	25/103 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847997
Domainoid	1	1.000	85	1.000	Domainoid score	I8160
eggNOG	1	0.900	-	-		E1_KOG1318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4416
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		otm43034
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45776
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1708
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.890